Research about the damage of lung exposed by Asian sand dust.
| Project/Area Number |
22590559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
INOUE Sumiko 鈴鹿医療科学大学, 薬学部, 准教授 (20378657)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAKU Yuusuke (30324510)
KAWANISHI Shousuke (10025637)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 黄砂 / 肺細胞 / ICR マウス / 炎症 / 8-ニトログアニン / 8-oxodG / 酸化的損傷 / プロテオミクス / OVA / SiO_2 / 肺 / 8-nitroguanine / プロテオーム / ICRマウス / Al_2O_3 |
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| Research Abstract |
The potential pulmonary toxicity by Asian sand dust was investigated. ICR mice were given suspended Asian sand dust with saline by intranasal droplet application once/a week, totally 4 times. Histologically examined lungs showed inflammation by Asian sand dust and association of oxidative stress. Quantitative study by HPLC showed 8-oxodG in lung of mice exposed by Asian sand dust increased significantly. These results suggest that Asian sand dust induces the formation of oxidative species in the lung and leads to inflammation.
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Report
(4 results)
Research Products
(7 results)
