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Determination of Helicobacter pylori infection origin in Japan

Research Project

Project/Area Number 22590613
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionAichi Medical University

Principal Investigator

KIKUCHI Shogo  愛知医科大学, 医学部, 教授 (40224901)

Co-Investigator(Kenkyū-buntansha) OKUDA Masumi  兵庫医科大学, 医学部, 准教授 (40531091)
OOSAKI Takako  杏林大学, 医学部, 講師 (90255406)
FUKUDA Yoshihiro  兵庫医科大学, 医学部, 教授 (60148640)
KAMIYA Shigeru  杏林大学, 医学部, 教授 (10177587)
Co-Investigator(Renkei-kenkyūsha) YINGSONG Lin  愛知医科大学, 医学部, 准教授 (50340302)
YAGYU Kiyoko  愛知医科大学, 医学部, 講師 (50268017)
UEDA Junko  愛知医科大学, 医学部, 助教 (90454339)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsヘリコバクター・ピロリ / 小児 / 感染防止 / 家族内感染 / 便中抗原 / 血清ペプシ ノゲン / 尿中抗体 / Hlicobacter pylori / 中学生 / 血清ペプシノゲン / 血清抗体 / 疫学 / Helicobacter pylori / 有病率 / 羅患率 / 感染源 / random amplified polymorphic DNA-fingerprint / RAPD-fingerprint
Research Abstract

Helicobacter pylori antigen was detected in stool samples from children of nursery schools, kindergartens, and primary schools. In 2010, 13 of 688 children was antigen positive (prevalence was 1.9%) and in 2011 15 of 835 was positive (1.8%), which was lower compared with prevalence in adults. H. pylori prevalence was higher in family members of H. pylori positive children than in those of negative ones. The difference was especially clear among mothers and fathers. Four-hundred-thirty-nine children (8 of them were positive) who gave samples twice with one-year interval showed no change in H. pylori infection status. Fourteen of 377 (prevalence was 4.2%) junior high school children were H. pylori antibody positive in urine or serum, which was higher compared with the younger children. Two of twelve H. pylori antigen positive junior high school children showed atrophic change defined by serum pepsinogen values. The proportion was smaller than that in adults, which indicates that eradication at these ages is more effective on gastric cancer prevention than at older ages, although safety of eradication at the young ages should be considered.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2013 2012 2011

All Journal Article (17 results) (of which Peer Reviewed: 7 results) Presentation (25 results) Book (1 results)

  • [Journal Article] Multilocus sequence typing of DNA from faecal specimens for the analysis of intra-familial transmission of Helicobacter pylori.2013

    • Author(s)
      Osaki T, Okuda M, Ueda J, Konno M, Yonezawa H, Hojo F, Yagyu K, Lin Y, Fukuda Y, Kikuchi S, Kamiya S.
    • Journal Title

      J Med Microbiol

      Volume: 62(Pt 5) Pages: 761-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic accuracy of urine-based kits for detection of Helicobacter pylori antibody in children.2013

    • Author(s)
      Okuda M, Kamiya S, Booka M, Kikuchi S, Osaki T, Hiwatani T, Maekawa K, Fukuda Y.
    • Journal Title

      Pediatr Int.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胃がんリスク評価-ABC分類の問題点と対策2013

    • Author(s)
      菊地正悟
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 14(2) Pages: 94-98

    • Related Report
      2012 Final Research Report
  • [Journal Article] Multilocus sequence typing of DNA from faecal specimens for the analysis of intra-familial transmission of Helicobacter pylori.2013

    • Author(s)
      Osaki T
    • Journal Title

      J Med Microbiol.

      Volume: 62 Issue: 5 Pages: 761-765

    • DOI

      10.1099/jmm.0.053140-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic accuracy of urine-based kits for detection of Helicobacter pylori antibody in children2013

    • Author(s)
      Okuda M
    • Journal Title

      Pediatr Int

      Volume: 印刷中 Issue: 3 Pages: 337-341

    • DOI

      10.1111/ped.12057

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本におけるHelicobacter pyloriの疫学-epidemiology of Helicobacter pylori in Japan. Helicobacter2012

    • Author(s)
      菊地正悟
    • Journal Title

      Research

      Volume: 16(5)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集:胃癌の予防と治療I.総論疫学の視点から実施すべき2つの胃癌予防2012

    • Author(s)
      菊地正悟
    • Journal Title

      日本臨床

      Volume: 70(10) Pages: 1673-78

    • Related Report
      2012 Final Research Report
  • [Journal Article] 若年者除菌による胃癌予防の試み(a)小児の Helicobacter pylori 感 染の現状と対策2012

    • Author(s)
      菊地正悟
    • Journal Title

      THE GI FOREFRONT

      Volume: 8(2) Pages: 22-24

    • Related Report
      2012 Final Research Report
  • [Journal Article] H.pylori 除菌による胃癌発生予防(1) H.pylori 除菌による胃がん予防 のこれまでと我が国の今後の胃がん対策2012

    • Author(s)
      菊地正悟
    • Journal Title

      臨床消化器内科

      Volume: 27(3) Pages: 269-75

    • Related Report
      2012 Final Research Report
  • [Journal Article] 胃がんリスク評価-ABC分類の問題点と対策2012

    • Author(s)
      菊地正悟
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 14 Pages: 94-8

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 特集:胃癌の予防と治療 I.総論 疫学の視点から実施すべき2つの胃癌予防2012

    • Author(s)
      菊地正悟
    • Journal Title

      日本臨床

      Volume: 70 Pages: 1673-8

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 若年者除菌による胃癌予防の試み(a)小児のHelicobacter pylori感染の現状と対策2012

    • Author(s)
      菊地正悟
    • Journal Title

      THE GI FOREFRONT

      Volume: 8 Pages: 22-4

    • Related Report
      2012 Annual Research Report
  • [Journal Article] H.pylori除菌による胃癌発生予防(1) H.pylori除菌による胃がん予防のこれまでと我が国の今後の胃がん対策2012

    • Author(s)
      菊地正悟
    • Journal Title

      臨床消化器内科

      Volume: 27 Pages: 269-275

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 日本におけるHelicobacter pyloriの疫学 - Epidemiology of Helicobacter pylori in Japan-2012

    • Author(s)
      菊地正悟
    • Journal Title

      Helicobacter Research

      Volume: 16 Pages: 375-7

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Comparative epidemiology of gastric cancer between Japan and China.2011

    • Author(s)
      Lin Y, Ueda J, Kikuchi S, Totsuka Y, Wei WQ, Qiao YL, Inoue M.
    • Journal Title

      World J Gastroenterol.

      Volume: 17(39) Pages: 4421-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced serum vascular endothelial growth factor receptor-2 (sVEGFR-2) and sVEGFR-1 levels in gastric cancer patients.2011

    • Author(s)
      Kikuchi S, Obata Y, Yagyu K, Lin Y, Nakajima T, Kobayashi O, Kikuichi M, Ushijima R, Kurosawa M, Ueda J.
    • Journal Title

      Cancer Sci.

      Volume: 102(4) Pages: 866-9

    • NAID

      10029292693

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] わが国の胃がん発生の変化とその対策(平成23年10月29日(土)2011

    • Author(s)
      菊地正悟
    • Journal Title

      山形県医師会消化器検診研修会講演)山形県医師会学術雑誌

      Volume: 43 Pages: 19-19

    • Related Report
      2012 Final Research Report
  • [Presentation] わが国小児のHericobacter pylori感染源の検索2012

    • Author(s)
      上田純子
    • Organizer
      第22回日本疫学会学術総会
    • Place of Presentation
      一橋記念講堂(東京)
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prevalenceand incidence of Helicobacter pyloriinfection in Japanese children.2012

    • Author(s)
      Kikuchi S, Okuda M, Ueda J, Osaki T, Yagyu K, Lin Y, Kamiya S.
    • Organizer
      WCPGHAN 2012-4th World Congress of Pediatric Gastroenterology, Hepatology And Nurtrision.
    • Place of Presentation
      Taipei,台湾
    • Related Report
      2012 Final Research Report
  • [Presentation] Intrafamilial transmission ofHelicobacter pylori infection in a rural area of Japan.2012

    • Author(s)
      Okuda M, Kikuchi S, Ueda J, Osaki T, Maekawa K, Kamiya S, Fukuda Y.
    • Organizer
      WCPGHAN 2012-4thWorld Congress of Pediatric Gastroenterology, Hepatology And Nurtrision.
    • Place of Presentation
      Taipei,台湾
    • Related Report
      2012 Final Research Report
  • [Presentation] Incidence ofHelicobacter pylori infection in children during a 1-year follow-up andthe infection status in families in a rural area of Japan.2012

    • Author(s)
      Okuda M, Kikuchi S, Ueda J, Osaki T, Yagyu K, Lin Y, Maekawa K, YonezawaH, Kamiya S, Fukuda Y.
    • Organizer
      European Helicobacter Study Group XXVth International Workshop onHelicobacter and related bacteria in chronic digestive inflammation and gastric cancer.
    • Place of Presentation
      Ljublajana,スロヴァニア
    • Related Report
      2012 Final Research Report
  • [Presentation] Prevalence of Helicobacter pyloriinfection in children in SASAYAMA-CITY.2012

    • Author(s)
      Ueda J, Okuda M, Osaki T, Yagyu K, Lin Y, Maekawa K, Yonezawa H,Kamiya S, Fukuda Y, Kikuchi S.
    • Organizer
      European Helicobacter Study Group XXVth International Workshop on Helicobacter and related bacteria inchronic digestive inflammation and gastric cancer.
    • Place of Presentation
      Ljublajana,スロヴァニア
    • Related Report
      2012 Final Research Report
  • [Presentation] わが国小児のHericobacter pylori感染源の検索.2012

    • Author(s)
      上田純子,菊地正悟,柳生聖子,林櫻松,奥田真珠美,前川講平,福田能啓,大崎敬子,米沢英雄,神谷茂.
    • Organizer
      第22回日本疫学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 小児へのH.pylori感染防止による胃がん予防2012

    • Author(s)
      菊地正悟,奥田真珠美,上田純子,大崎敬子,柳生聖子,林櫻松,神谷茂,福田能啓
    • Organizer
      第18回日本ヘリコバクター学会学術集会
    • Place of Presentation
      岡山
    • Related Report
      2012 Final Research Report
  • [Presentation] 糞便材料を用いたMLST法によるHelicobacter pylori感染源の家族内検索2012

    • Author(s)
      大崎敬子,奥田真珠美,上田純子,米澤英雄,北条史,柳生聖子,林櫻松,福田能啓,菊地正悟,神谷茂.
    • Organizer
      第18回日本ヘリコバクター学会学術集会
    • Place of Presentation
      (ポスター)岡山
    • Related Report
      2012 Final Research Report
  • [Presentation] 小児のH. pylori感染状況と追跡調査-篠山スタディ第2報2012

    • Author(s)
      奥田真珠美,菊地正悟,大崎敬子,上田純子,米澤英雄,林櫻松,柳生聖子,北条史,神谷茂,福田能啓
    • Organizer
      第18回日本ヘリコバクター学会学術集会
    • Place of Presentation
      (ポスター)岡山
    • Related Report
      2012 Final Research Report
  • [Presentation] Prevalence of Helicobacter pylori infection in Japanese children and gastric cancer incidence in future; わが国小児の Helicobacter pylori 感染有病率と将来の胃がん発生2012

    • Author(s)
      菊地正悟,上田純子,柳生聖子,林 櫻松
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      (ポスター)札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Prevalence and incidence of Helicobacter pylori infection in Japanese children2012

    • Author(s)
      Kikuchi S
    • Organizer
      WCPGHAN 2012-4th World Congress of Pediatric Gastroenterology, Hepatology And Nurtrision
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Intra-familial transmission of Helicobacter pylori infection in a rural area of Japan.2012

    • Author(s)
      Okuda M
    • Organizer
      WCPGHAN 2012-4th World Congress of Pediatric Gastroenterology, Hepatology And Nurtrision
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cut off values should be reconsidered in serological risk evaluation of gastric cancer in Japan2012

    • Author(s)
      Yagyu K
    • Organizer
      European Helicobacter Study Group XXVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Ljublajana, Slovenia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Incidence of Helicobacter pylori infection in children during a 1-year follow-up and the infection status in families in a rural area of Japan2012

    • Author(s)
      Okuda M
    • Organizer
      European Helicobacter Study Group XXVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Ljublajana, Slovenia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Prevalence of Helicobacter pylori infection in children in SASAYAMA-CITY2012

    • Author(s)
      Ueda J
    • Organizer
      European Helicobacter Study Group XXVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Ljublajana, Slovenia
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小児のH.pylori感染率-篠山スタディ2011

    • Author(s)
      奥田真珠美
    • Organizer
      第17回日本ヘリコバクター学会学術集会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血清Hericobacter pylori抗体の小児における診断能2011

    • Author(s)
      上田純子
    • Organizer
      第17回日本ヘリコバクター学会学術集会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prevalence ofhelicobacter pylori infection in children in a rural area of Japan.2011

    • Author(s)
      Kikuchi S, Okuda M, Ueda J, Osaki T, Yagyu K, Lin Y, Maekawa K, YonezawaH, Kamiya S, Fukuda Y.
    • Organizer
      EuropeanHericobacter Study Group XXVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Dublin,アイルランド
    • Related Report
      2012 Final Research Report
  • [Presentation] Intrafamilialtransmission of hericobacter pylori infection in a rural area of Japan.2011

    • Author(s)
      Okuda M, Kikuchi S, Osaki T, Ueda J, Mekawa K, Yagyu K, Lin Y, YonezawaH, Kamiya S, Fukuda Y.
    • Organizer
      European Hericobacter Study Group XXVth International Workshop onHelicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Dublin, アイルランド
    • Related Report
      2012 Final Research Report
  • [Presentation] 血清Hericobacter pylori抗体の小児における診断能2011

    • Author(s)
      上田純子,奥田真珠美,福田能啓,菊地正悟
    • Organizer
      第17回日本ヘリコバクター学会学術集会
    • Place of Presentation
      富山
    • Related Report
      2012 Final Research Report
  • [Presentation] 小児のH. pylori感染率-篠山スタディ2011

    • Author(s)
      奥田真珠美,菊地正悟,大崎敬子,上田純子,神谷茂,米澤英雄,林櫻松,福田能啓
    • Organizer
      第17回日本ヘリコバクター学会学術集会
    • Place of Presentation
      富山
    • Related Report
      2012 Final Research Report
  • [Presentation] 小児におけるHelicobacter pyloriの陽性率2011

    • Author(s)
      菊地正悟,上田純子,柳生聖子,林櫻松,奥田真珠美,福田能啓,大崎敬子,神谷茂
    • Organizer
      がん予防大会2011京都
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃がんの疫学に関する日中比較2011

    • Author(s)
      林櫻松,菊地正悟,上田純子,戸塚ゆ加里,井上真奈美
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Intrafamilial transmission of bericobacter pylori infection in a rural area of Japan2011

    • Author(s)
      Masumi OKUDA
    • Organizer
      第24回欧州ヘリコバクター学会
    • Place of Presentation
      Trinity College(ダブリン、アイルランド)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prevalence of helicobacter pylori infection in children in a rural area of Japan2011

    • Author(s)
      Shogo KIKUCHI
    • Organizer
      第24回欧州ヘリコバクター学会
    • Place of Presentation
      Trinity College(ダブリン、アイルランド)
    • Related Report
      2011 Annual Research Report
  • [Book] 新しい診断と治療のABC[6]消化性潰瘍 消化器1(編集)浅香正博. 第一章概論・疫学2012

    • Author(s)
      菊地正悟
    • Publisher
      最新医学社
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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