Clinical efficacy and its molecular mechanisms of ninjinyoeito on oxaliplatin-induced peripheral neuropathy
| Project/Area Number |
22590669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAIKI Ikuo 富山大学, 和漢医薬学総合研究所, 教授 (80133776)
TAKANO Fumihide 日本薬科大学, 薬学部, 准教授 (20236251)
MAKINO Toshikaki 名古屋市立大学, 大学院・薬学研究科, 准教授 (80326561)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIGAKI Yasuhito 金沢医科大学, 総合医学研究所, 准教授 (20232275)
SHIMASAKI Takeo 金沢医科大学, 総合医学研究所, 講師 (50377420)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 大腸癌 / オキサリプラチン / 末梢神経障害 / 人参養栄湯 / 漢方 / 人参栄養湯 / 癌 / 内科 / 臨床 / 抗がん剤 |
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| Research Abstract |
In a pilot clinical trial, ninjinyoeito (NYT) was administered to 22 patients with advanced or recurrent colorectal cancer from the beginning of FOLFOX or XELOX, which contained oxaliplatin (L-OHP). Maximal peripheral neuropathy was grade2 in all patients during the observation period. In a mouse model, L-OHP (i.p.)induced cold hypersensitivity and mechanical allodynia, but NYT significantly attenuated these findings. In PC12 cells, L-OHP shortened nerve growth factor-induced neurite outgrowth, which NYT (300 μg/ml) recovered.
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Report
(4 results)
Research Products
(140 results)
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[Journal Article] Loss of HITS (FAM107B) expression in cancers of multiple organs : tissue microarray analysis2012
Author(s)
Nakajima H, Koizumi K, Tanaka T, Ishigaki Y, Yoshitake Y, Yonekura H, Sakuma T, Fukushima T, Umehara H, Ueno S, Minamoto T and Motoo Y
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Journal Title
International journal of oncology
Volume: 41
Issue: 4
Pages: 1347-1357
DOI
Related Report
Peer Reviewed
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[Presentation] Curcumin and Cancer Metastasis.2010
Author(s)
Saiki I,Ohashi Y,Tsuchiya Y,Koizumi K,Sakurai H.
Organizer
The 9 th Joint Seminar"Natural Medicine Research for the Next Decade:New Challenges and Future Collaboration",NRCT-JSPS Core University ProgramonNatural Medicinein Pharmaceutical Sciences
Place of Presentation
Bankok
Year and Date
2010-12-08
Related Report
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[Presentation] The Controlling of Lymphangiogenesis.2010
Author(s)
Prangsaengtong O,Koizumi K,Senda K,Urano T,Nagata A,Sakurai H,Tohda C,Saiki I.
Organizer
The 9th Joint Seminar"Natural Medicine Research for the Next Decade: New Challengesand Future Collaboration",NRCT-JSPS Core University Programon Natural Medicinein Pharmaceutical Sciences
Place of Presentation
Bankok, Thailand
Year and Date
2010-12-08
Related Report
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