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The relationship between chronic injury and the origin of the liver tumor analyzed using mouse model

Research Project

Project/Area Number 22590717
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

ASAOKA Yoshinari  東京大学, 医学部附属病院, 助教 (90431858)

Co-Investigator(Kenkyū-buntansha) SASAKI Takashi  東京大学, 医学部附属病院, 助教 (10569106)
伊地知 秀明  東京大学, 医学部附属病院, 助教 (70463841)
池上 恒雄  東京大学, 医科学研究所, 准教授 (80396712)
Co-Investigator(Renkei-kenkyūsha) IKENOUE Tsuneo  東京大学, 医科学研究所, 准教授 (80396712)
Research Collaborator IJICHI Hideaki  東京大学, 医学部附属病院, 助教 (70463841)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords胆管癌 / マウスモデル / 肝癌 / 細胞内シグナル伝達 / 肝臓学 / 肝内胆管癌
Research Abstract

We generated hepatic cancer mouse model by inducing expression of activated Kras and ablation of Pten under albumin-promoter. The mice died from multipe liver tumor in 7 to 8 weeks. Using genomic analysis of SNP array, we found that Hippo pathway, a novel intracellular signaling, was involved in hepatocarcinogenesis. Aberration of SAV1, a component of the pathway, was shown to induce the activation of YAP/TAZ and following expression of CTGF in a liver cancer cell line.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (4 results)

  • [Journal Article] Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation2012

    • Author(s)
      Kudo Y, Aburatani H, et al.
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 4 Pages: 670

    • DOI

      10.1111/j.1349-7006.2012.02213.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of Gli by cAMP-Dependent Protein Kinase2012

    • Author(s)
      Asaoka Y.
    • Journal Title

      Vitam Horm

      Volume: 88 Pages: 293-307

    • DOI

      10.1016/b978-0-12-394622-5.00013-4

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] IGF-II producing hepatocellular carcinoma treated with sorafenib: Metabolic complications and a foresight to molecular targeting therapy to the IGF signal2012

    • Author(s)
      Okushin K, Asaoka Y, Fukuda I,Fujiwara N, Minami T, Sato M, Mikami S,Uchino K, Enooku K, Kondo Y, Tateishi R, Goto T, Shiina S, Yoshida H, Koike K.
    • Journal Title

      Case Rep Gastroenterol

      Volume: 6 Issue: 3 Pages: 784

    • DOI

      10.1159/000346462

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine.2012

    • Author(s)
      Sasaki T, Isayama H, Nakai Y, Mizuno S, Yamamoto K, YagiokaH, Yashima Y, Kawakubo K, Kogure H, Togawa O, Matsubara S, Ito Y, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K.
    • Journal Title

      Invest New Drugs

      Volume: 0(2) Issue: 2 Pages: 708-13

    • DOI

      10.1007/s10637-010-9553-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of RAS protein activator like-1 in gastric cancer2011

    • Author(s)
      Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M.
    • Journal Title

      Int J Cancer

      Volume: 128 Issue: 6 Pages: 1293

    • DOI

      10.1002/ijc.25459

    • URL

      https://pure.teikyo.jp/en/publications/20166cc9-0fa9-45ad-a966-3b94d2003aac

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: Impact on patient's prognosis2011

    • Author(s)
      Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
    • Journal Title

      Liver Int

      Volume: 31 Issue: 2 Pages: 197

    • DOI

      10.1111/j.1478-3231.2010.02415.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients2011

    • Author(s)
      Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
    • Journal Title

      Int J Cancer

      Volume: 129 Issue: 9 Pages: 2226

    • DOI

      10.1002/ijc.25861

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] New targeted therapies for gastric cancer2011

    • Author(s)
      Asaoka Y, Ikenoue T, Koike K.
    • Journal Title

      Expert Opin Investig Drugs

      Volume: 20 Issue: 5 Pages: 595

    • DOI

      10.1517/13543784.2011.566863

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy2011

    • Author(s)
      Sasaki T, Isayama H, Nakai Y, Togawa O, Kogure H, Ito Y, Yamamoto K, Mizuno S, Yagioka H,Yashima Y, Kawakubo K, Arizumi T, Matsubara S, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K.
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 67 Issue: 4 Pages: 847

    • DOI

      10.1007/s00280-010-1360-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer.2011

    • Author(s)
      Sasaki T, Isayama H, Nakai Y, Mizuno S, Yamamoto K, Yagioka H, Yashima Y, Kawakubo K, Kogure H, Togawa O, Matsubara S, Sasahira N, Hirano K, Tsujino T, Tada M, Omata M, Koike K.
    • Journal Title

      Invest New Drugs

      Volume: 29(6) Issue: 6 Pages: 1488-93

    • DOI

      10.1007/s10637-010-9485-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer2010

    • Author(s)
      Tada M, Kanai F, Tanaka Y, Sanada M, Nannya Y, Tateishi K, Ohta M, Asaoka Y, Seto M, Imazeki F, Yoshida H, Ogawa S, Yokosuka O, Omata M
    • Journal Title

      Cancer Sci

      Volume: 101 Issue: 5 Pages: 1261

    • DOI

      10.1111/j.1349-7006.2010.01500.x

    • NAID

      10026592643

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion2010

    • Author(s)
      Asaoka Y, Tada M, Ikenoue T, Seto M, Imai M, Miyabayashi K, Yamamoto K, Yamamoto S, Kudo Y, Mohri D, Isomura Y, Ijichi H, Tateishi K, Kanai F, Ogawa S, Omata M, Koike K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 394 Issue: 4 Pages: 1042

    • DOI

      10.1016/j.bbrc.2010.03.120

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genetic polymorphism of CYP2C19 is associated with susceptibility to biliary tract cancer2010

    • Author(s)
      Isomura Y, Yamaji Y, OhtaM, Seto M, Asaoka Y, Tanaka Y, Sasaki T, Nakai Y, Sasahira N, Isayama H, Tada M, Yoshida H, Kawabe T, Omata M, Koike K.J
    • Journal Title

      Gastroenterol

      Volume: 45 Issue: 10 Pages: 1045

    • DOI

      10.1007/s00535-010-0246-0

    • NAID

      10027699389

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter, phase II study of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer.2010

    • Author(s)
      Sasaki T, Isayama H, Nakai Y, Ito Y, Kogure H, Togawa O, Toda N, Yasuda I, Hasebe O, Maetani I,Sasahira N, Hirano K, Tsujino T, Tada M, Omata M.
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 65(6) Issue: 6 Pages: 1101-7

    • DOI

      10.1007/s00280-009-1115-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Hippoシグナル異常を伴う肝細胞癌における受容体型チロシンキナーゼに関する検討2011

    • Author(s)
      浅岡良成
    • Organizer
      JDDW2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝細胞癌におけるHippoシグナルの異常に関する検討2011

    • Author(s)
      浅岡良成
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Recurrent SAV1 Mutations InHepatocellular Carcinoma2011

    • Author(s)
      Asaoka Y.
    • Organizer
      APASL2011
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2011-02-20
    • Related Report
      2012 Final Research Report
  • [Presentation] SNPアレイを用いた胃癌細胞株における受容体型チロシンキナーゼ遺伝子異常に関する検討.2010

    • Author(s)
      浅岡良成
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-13
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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