| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We demonstrated an association between IL28B and ITPA genotypes and response to antiviral therapy and adherence to therapy, respectively, in chronic hepatitis C patients. Association between PNPLA3 genotype and non-alcoholic fatty liver diseases or severe steatois in chronic hepatitis C and association between PNPLA3 genotype and development of hepatocellular carcinoma (HCC) in chronic hepatitis C patients who had been treated with antiviral therapy were revealed. Finally, association between PNPLA3 genotype and HCC of non-viral origin and association between MICA genotype and hepatitis C virus-related HCC were demonstrated by an analysis of a substantial number of patients.
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