Establishment of evidence on the pathophysiology and treatment in Japanese patients with acute myocardial infarction

• Project/Area Number: 22590785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: KOJIMA Sunao 熊本大学, 医学部附属病院, 准教授 (50363528)
• Research Collaborator: ISHIHARA Masaharu ; KOSUGE Masami ; ISHII Hideki ; MASUNAGA Nobutaka ; FUJII Noriyuki ; NAKAMURA Mashio ; HIGUMA Takumi ; HORII Manabu ; FUKUNAGA Takashi ; KOSHO Hideyasu ; TAKANO Hitoshi ; FUJII Kenichi
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 急性心筋梗塞 / レジストリー / 心筋梗塞 / 虚血性心疾患 / JACSS / 性差 / 血糖 / 尿酸 / 白血球 / 硝酸薬

Outline of Final Research Achievements

The incidence of acute myocardial infarction (AMI) in Japan has increased until 2000; however, in the US, it has decreased since before 2000. Currently, there is no national registry data related to AMI in Japan, on a municipal or prefectural level. We established the Kumamoto Acute Coronary Events study group to examine the accurate incidence of AMI in the Kumamoto Prefecture by registering all cases and studying recent trends. The number of people with advanced age in Kumamoto Prefecture has gradually increased. In 2004-2011, 8,131 AMI patients were registered; age-adjusted AMI incidence in men decreased from 93.1 in 2004 to 70.7 in 2011 (P=0.0294). Age-adjusted in-hospital cardiac death rate was maintained at ~7%; however, all-cause mortality and non-cardiac death rate increased and appeared to be related. A steady trend of decreasing AMI incidence was observed. Urgent measures should be established against non-cardiac mortality in this era of an aging population.

Research Products

• [Journal Article] Single-wire pressure and flow velocity measurement for quantifying microvascular dysfunction in patients with coronary vasospastic angina. (2015)
  • Author(s): Yamanaga K, Tsujita K, Komura N, Kaikita K, Sakamoto K, Miyazaki T, Saito M, Ishii M, Tabata N, Akasaka T, Sato K, Horio E, Arima Y, Kojima S, Tayama S, Nakamura S, Hokimoto S, Ogawa H.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 308
  • Peer Reviewed / Open Access
• [Journal Article] Impact of left ventricular hypertrophy on impaired coronary microvascular dysfunction. (2015)
  • Author(s): Tsujita K, Yamanaga K, Komura N, Sakamoto K, Miyazaki T, Ishii M, Tabata N, Akasaka T, Sueta D, Arima Y, Kojima S, Yamamoto E, Yamamuro M, Tanaka T, Izumiya Y, Tayama S, Nakamura S, Kaikita K, Hokimoto S, Ogawa H.
  • Journal Title: Int J Cardiol Volume: 187 Pages: 411-413
  • DOI: 10.1016/j.ijcard.2015.03.367
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Features and Prognosis of Patients With Coronary Spasm Induced Non ST Segment Elevation Acute Coronary Syndrome. (2014)
  • Author(s): Nakayama N, Kaikita K, Fukunaga T, Matsuzawa Y, Sato K, Horio E, Yoshimura H, Mizobe M, Takashio S, Tsujita K, Kojima S, Tayama S, Hokimoto S, Sakamoto T, Nakao K, Sugiyama S, Kimura K, Ogawa H.
  • Journal Title: Journal of the American Heart Association Volume: 3 Issue: 3
  • DOI: 10.1161/jaha.114.000795
  • Peer Reviewed / Open Access
• [Journal Article] Serial intravascular ultrasound assessment of very late stent thrombosis after sirolimus-eluting stent placement. (2014)
  • Author(s): Yamanaga K, Tsujita K, Shimomura H, Nakamura Y, Ogura Y, Onoue Y, Chazono N, Nagata T, Morisaki S, Kudo T, Yamada Y, Komura N, Miyazaki T, Akasaka T, Horio E, Sato K, Arima Y, Kojima S, Kaikita K, Tayama S, Hokimoto S, Ogawa H.
  • Journal Title: Journal of Cardiology Volume: 64 Issue: 4 Pages: 279-284
  • DOI: 10.1016/j.jjcc.2014.02.008
  • Peer Reviewed
• [Journal Article] Chronic thromboembolic pulmonary hypertension complicated with homocystinuria. (2014)
  • Author(s): Ogawa S, Katayama T, Kaikita K, Tsukamoto M, Yamamoto E, Yamamuro M, Tanaka T, Tsujita K, Kojima S, Tayama S, Hokimoto S, Yamabe H, Indo Y, Endo F, Matsubara H, Ogawa H.
  • Journal Title: Intern Med Volume: 53 Pages: 2605-2608
  • NAID: 130004713239
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure. (2014)
  • Author(s): Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda O, Yamashita Y, Ogawa H.
  • Journal Title: American Journal of Cardiology Volume: 113 Issue: 10 Pages: 1697-1704
  • DOI: 10.1016/j.amjcard.2014.02.029
  • Peer Reviewed / Open Access
• [Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts. (2014)
  • Author(s): Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Journal Title: Heart Vessels. Volume: 29 Issue: 2 Pages: 231-237
  • DOI: 10.1007/s00380-013-0337-y
  • Peer Reviewed
• [Journal Article] Lower Framingham risk score and the absence of hypertension are associated with the morning peak in the circadian variation of ST-elevation myocardial infarction onset. (2014)
  • Author(s): Usuku H, Izumiya Y, Sugiyama S, Kojima S, Araki S, Kurogi K, Yamamoto N, Ando Y, Ogawa H.
  • Journal Title: Hypertens Res. Volume: 37 Issue: 3 Pages: 239-245
  • DOI: 10.1038/hr.2013.139
  • Peer Reviewed
• [Journal Article] Comprehensive analysis of intravascular ultrasound and angiographic morphology of culprit lesions between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome. (2014)
  • Author(s): Takaoka N, Tsujita K, Kaikita K, Hokimoto S, Mizobe M, Nagano M, Horio E, Sato K, Nakayama N, Yoshimura H, Yamanaga K, Komura N, Kojima S, Tayama S, Nakamura S, Ogawa H.
  • Journal Title: Int J Cardiol. Volume: 171 Issue: 3 Pages: 423-430
  • DOI: 10.1016/j.ijcard.2013.12.094
  • Peer Reviewed
• [Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction. (2014)
  • Author(s): Izumiya Y, Hanatani S, Kimura Y, Takashio S, Yamamoto E, Kusaka H, Tokitsu T, Rokutanda T, Araki S, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
  • Journal Title: Can J Cardiol. Volume: 30 Issue: 3 Pages: 338-344
  • DOI: 10.1016/j.cjca.2013.12.010
  • Peer Reviewed
• [Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts outcome of heart failure with reduced ejection fraction. (2014)
  • Author(s): Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
  • Journal Title: Circ J. Volume: 78 Pages: 903-910
  • NAID: 130003391038
  • Peer Reviewed
• [Journal Article] Coronary plaque component in patients with vasospastic angina: a virtual histology intravascular ultrasound study. (2013)
  • Author(s): Tsujita K, Sakamoto K, Kojima S, Kojima S, Takaoka N, Nagayoshi Y, Sakamoto T, Tayama S, Kaikita K, Hokimoto S, Sumida H, Sugiyama S, Nakamura S, Ogawa H.
  • Journal Title: Int J Cardiol. Volume: 168 Issue: 3 Pages: 2411-2415
  • DOI: 10.1016/j.ijcard.2013.02.002
  • Peer Reviewed
• [Journal Article] Neointimal tissue component assessed by tissue characterization with 40 MHz intravascular ultrasound imaging: comparison of drug-eluting stents and bare-metal stents. (2013)
  • Author(s): Tsujita K, Takaoka N, Kaikita K, Hokimoto S, Horio E, Sato K, Mizobe M, Nakayama N, Kojima S, Tayama S, Sugiyama S, Nakamura S, Ogawa H.
  • Journal Title: Catheter Cardiovasc Interv. Volume: 82 Issue: 7 Pages: 1068-1074
  • DOI: 10.1002/ccd.24907
  • Peer Reviewed
• [Journal Article] Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure. (2013)
  • Author(s): Takashio S, Yamamuro M, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
  • Journal Title: J Am Coll Cardiol. Volume: 62 Issue: 7 Pages: 632-640
  • DOI: 10.1016/j.jacc.2013.03.065
  • Peer Reviewed
• [Journal Article] Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm: analysis of a single-center study over 20 years. (2013)
  • Author(s): Sato K, Kaikita K, Nakayama N, Horio E, Yoshimura H, Ono T, Ohba K, Tsujita K, Kojima S, Tayama S, Hokimoto S, Matsui K, Sugiyama S, Yamabe H, Ogawa H.
  • Journal Title: J Am Heart Assoc. Volume: 15 Issue: 4
  • DOI: 10.1161/jaha.113.000227
  • Peer Reviewed
• [Journal Article] Temporal trends in hospitalization for acute myocardial infarction between 2004 and 2011 in Kumamoto, Japan. (2013)
  • Author(s): Kojima S, Matsui K, Ogawa H; Kumamoto Acute Coronary Events (KACE) Study Group.
  • Journal Title: Circ J Volume: 77 Pages: 2841-2843
  • NAID: 10031196839
  • Peer Reviewed
• [Journal Article] Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease. (2012)
  • Author(s): Keisuke Ohba
  • Journal Title: J Am Heart Assoc Volume: 1 Issue: 5
  • DOI: 10.1161/jaha.112.002485
  • Peer Reviewed
• [Journal Article] Diagnostic and prognostic value of subcutaneous tissue biopsy in patients with cardiac amyloidosis. (2012)
  • Author(s): Seiji Takashio
  • Journal Title: Am J Cardiol Volume: 110 Issue: 10 Pages: 1507-11
  • DOI: 10.1016/j.amjcard.2012.06.059
  • Peer Reviewed
• [Journal Article] Significance of Coronary Vasospasm in the Perioperative Management of Non-Cardiac Surgery (2012)
  • Author(s): Yasuhiro Nagayoshi
  • Journal Title: Circulation Journal Volume: 76 Issue: 8 Pages: 1965-1971
  • DOI: 10.1253/circj.CJ-11-1278
  • NAID: 10030504850
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Usefulness of SUM of ST-segment elevation on electrocardiograms (limb leads) for predicting in-hospital complications in patients with stress (takotsubo) cardiomyopathy. (2012)
  • Author(s): Seiji Takashio
  • Journal Title: Am J Cardiol Volume: 109 Issue: 11 Pages: 1651-6
  • DOI: 10.1016/j.amjcard.2012.01.393
  • Peer Reviewed
• [Journal Article] Recurrence of angina pectoris after percutaneous coronary intervention is reduced by statins in Japanese patients (2011)
  • Author(s): Ryusuke Tsunoda, Tomohiro Sakamoto, Sunao Kojima, Yasuhiro Ogata, Akira Kitagawa, Hisao Ogawa
  • Journal Title: Journal of Cardiology Volume: 58 Issue: 3 Pages: 208-215
  • DOI: 10.1016/j.jjcc.2011.07.002
  • NAID: 10031159595
  • Peer Reviewed
• [Journal Article] Clinical Significance of Microalbuminuria in High-Risk Patients With Coronary Artery Disease (2011)
  • Author(s): Sunao Kojima, Hisao Ogawa
  • Journal Title: Circulation Journal Volume: 75 Issue: 12 Pages: 2765-2766
  • DOI: 10.1253/circj.CJ-11-1167
  • NAID: 10030033068
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Long-term use of oral nicorandil stabilizes coronary plaque in patient with stable angina pectoris (2011)
  • Author(s): Yasuhiro Izumiya, Sunao Kojima, et al
  • Journal Title: Atherosclerosis Volume: 214 Pages: 415-421
  • Peer Reviewed
• [Journal Article] Hypercholesterolemia and hypoadiponectinemia are associated with necrotic core-rich coronary plaque (2011)
  • Author(s): Shinobu Kojima, Sunao Kojima, et al
  • Journal Title: International Journal of Cardiology Volume: 147 Pages: 371-376
  • Peer Reviewed
• [Journal Article] Waveform of ophthalmic artery Doppler flow predicts the severity of systemic atherosclerosis (2010)
  • Author(s): Hidetomo Maruyoshi, Sunao Kojima, et al
  • Journal Title: Circulation Journal Volume: 74 Pages: 1251-1256
  • NAID: 10026475144
  • Peer Reviewed
• [Presentation] Design of JAMIR-KAMIR Collaborating Study (2015)
  • Author(s): Sunao Kojima
  • Organizer: The 79th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪市 中之島会場・グランフロント大阪会場
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Nocturia is a Clinical Sign of Sleep Disordered Breathing and Its Treatment May Prevent Sudden Cardiac Death (2015)
  • Author(s): 小島 淳
  • Organizer: The 79th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪市 中之島会場・グランフロント大阪会場
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] KACE (Kumamoto Acute Coronary Events) Study (2015)
  • Author(s): 小島 淳
  • Organizer: The 79th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪市 中之島会場・グランフロント大阪会場
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Acute Myocardial Infarction Registry-with the Aim of Realizing National Registry (2015)
  • Author(s): 小島 淳
  • Organizer: The 79th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪市 中之島会場・グランフロント大阪会場
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] JACSS(Japanese Acute Coronary Syndrome Study) (2015)
  • Author(s): 小島 淳
  • Organizer: The 79th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪市 中之島会場・グランフロント大阪会場
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Therapeutic Strategy for Efficient Reduction of Serum Uric Acid With Allopurinol versus Benzbromarone in Hyperuricemic Patients With Cardiovascular Disease ～A Randomized Crossover Study (TERAO study) (2014)
  • Author(s): Sunao Kojima, Hisao Ogawa.
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: Chicago, Illinois
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Asian Dust Has an Impact on the Incident of Acute Myocardial Infarction ~a Time-stratified Case-Crossover Study (2014)
  • Author(s): Sunao Kojima, Hisao Ogawa.
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: Chicago, Illinois
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Severity of Sleep-Disordered Breathing Has an Impact on the Frequency of Nocturnal Enuresis -The Challenge With Continuous Positive Airway Pressure to Stop Nocturnal Enuresis in Cardiovascular Patients- (2014)
  • Author(s): Sunao Kojima, Hisao Ogawa.
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: Chicago, Illinois
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Different Presentation Mode of Acute Myocardial Infarction is Associated With Antecedent Therapy With Nitrates and β-blockers (2014)
  • Author(s): Sunao Kojima. The Japanese Acute Coronary Syndrome Study (JACSS) group.
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: Chicago, Illinois
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 市民による「救急の連鎖」の完遂は心原性心停止患者の予後を改善する (2014)
  • Author(s): 小島 淳、松井 邦彦、小川 久雄、米本 直裕、野々木 宏、長尾 建
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台市 仙台国際センター
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] The Multicenter Study for Aggressive Lipid-Lowering Strategy by HMG-CoA Reductase Inhibitors in Patients With Acute Myocardial Infarction (MUSASHI -AMI) Trial (2014)
  • Author(s): Sunao Kojima.
  • Organizer: Korean Cardiology-Related Joint Scientific Congress 2014
  • Place of Presentation: 大韓民国 光州広域市
  • Year and Date: 2014-04-18 – 2014-04-19
  • Invited
• [Presentation] 人口１８０万人における心筋梗塞および院外心原性心肺停止症例の全例登録データに基づいた横断的解析～日本における心筋梗塞登録事業の立ち上げを目指して～ (2014)
  • Author(s): 小島 淳
  • Organizer: 日本循環器学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 急性心筋梗塞レジストリー具体案の提示 (2014)
  • Author(s): 小島 淳
  • Organizer: 日本循環器学会
  • Place of Presentation: 東京国際フォーラム
  • Invited
• [Presentation] 心筋梗塞二次予防ガイドライン2011年改訂版＜硝酸薬に関する新たな知見＞ (2013)
  • Author(s): 小島 淳
  • Organizer: 日本心臓病学会
  • Place of Presentation: 熊本鶴屋ホール
• [Presentation] 熊本急性冠症候群研究会（KACE） (2013)
  • Author(s): 小島 淳
  • Organizer: 日本心臓病学会
  • Place of Presentation: ホテル日航熊本
  • Invited
• [Presentation] The incidence of acute myocardial infarction is decreasing but out-of-hospital cardiac arrest of cardiac origin is increasing in the completely registered data out of 1,800,000 prefectural inhabitants in an era of aging population (2013)
  • Author(s): Sunao Kojima
  • Organizer: American Heart Association
  • Place of Presentation: Dallas, Texas
• [Presentation] The Revision of American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care provides clinical benefit in women with out-of-hospital cardiac arrest undergoing prehospital defibrillation. (2012)
  • Author(s): Sunao Kojima
  • Organizer: American Heart Association the 85th Scientific Sessions
  • Place of Presentation: Los Angeles, California
• [Presentation] 熊本県における心筋梗塞に対する医療と行政の取り組み (2012)
  • Author(s): 小島淳
  • Organizer: 第26回日本冠疾患学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス
• [Presentation] 熊本急性冠症候群研究会（KACE）・Japanese acute coronary syndrome study (JACSS) (2012)
  • Author(s): 小島淳
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航金沢
• [Presentation] Strong statin treatment provides incremental clinical benefit in normoch olesterolemic diabetic patients with coronary heart disease (2011)
  • Author(s): Sunao Kojima
  • Organizer: American Heart Association the 84^<th> Scientific Sessions
  • Place of Presentation: Orlando, Florida(アメリカ)
• [Presentation] A physician onboard the advanced life support unit has a clinical impact on outcome of witnessed patients with out-of-hospital cardiac arrest (2010)
  • Author(s): Sunao Kojima
  • Organizer: American Heart Association the 83^<rd> Scientific Sessions
  • Place of Presentation: Chicago, Illinois McCormick Place
• [Book] 日本における急性心筋梗塞の現状～JACSSデータから得られたもの～ (2010)
  • Author(s): 小島淳、小川久雄
  • Total Pages: 105
  • Publisher: ホープ印刷株式会社