Identification of MicroRNAs involved in formation of foam cells that are associated with atherosclerosis-related gene lymphotoxin-alpha
| Project/Area Number |
22590827
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
SAKATA Yasuhiko 大阪大学, 大学院・医学系研究科, 助教 (90379206)
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| Co-Investigator(Kenkyū-buntansha) |
中谷 大作 大阪大学, 医学系研究科, 研究員 (60444535)
砂 真一郎 大阪大学, 歯学研究科, 助教 (40573085)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分子血管病態学 / 心筋梗塞 / 高血圧 / 遺伝子多型 / アンジオテンシン / マクロファージ / 動脈硬化 / マイクロRNA / リンホトキシンα |
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| Research Abstract |
We tried to Identify microRNAs involved in f ormation of foam cells that are associated with atherosclerosis-related gene lymphotoxin-alpha (LTA). However, we found that LTA was unlikely involved in foam cell formation. Thus, we changed our plan and identified microRNAs that are associated with cardiac death in patients who survived acute myocardial infarction, a major cause of death as a result of atherosclerotic diseases.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] on Behalf of The Osaka Acute Coronary Insufficiency Study (OACIS) Group Incidence Predictors, and Subsequent Mortality Risk of Recurrent Myocardial Infarction in Patients following Discharge for Acute Myocardial Infarction.2013
Author(s)
Nakatani D, Sakata Y, Suna S, Usami M, Matsumoto S, Shimizu M, Sumitsuji S, Kawano S, Ueda Y, Hamasaki T, Sato H, Nanto S, Hori M, Komuro I
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Journal Title
Circ J.
Volume: 77
Pages: 439-446
Related Report
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[Journal Article] A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction.2012
Author(s)
Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Nanto S, Hamasaki T, Hori M, Komuro I.
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Journal Title
Biochem Biophys Res Commun
Volume: 427
Pages: 280-4
Related Report
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[Presentation] Circulating MicroRNAs as Therepeutic Targets for Cardiac Remodeling and Heart Failure in Patients after Acute Myocardial Infarction.2013
Author(s)
Sen Matsumoto, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Masahiko Hara, Yukio Kawahara, Toru Oka, Seiji Takashima, Tatsuya Sasaki, Hiroshi Sato, Shinsuke Nanto, Issei Komuro
Organizer
日本循環器学会総会
Place of Presentation
横浜
Year and Date
2013-03-15
Related Report
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[Presentation] on behalf of Osaka Acute Coronary Insufficiency Study (OACIS) Group. Cardiovascular Events Associated with Lymphotoxin Alpha and its Polymorphism After the Onset of Myocardial Infarction2011
Author(s)
Shinichiro Suna, Yasuhiko Sakata, Daisaku Nakatani, Masaya Usamai, Sen Matsumoto, Keiji Okuda, Kouichi Ozaki, Seiji Takashima, Tetsuo Minamino, Toshihiro Tanaka, Hiroshi Sato, Masatsugu Hori, Shinsuke Nanto, Issei Komuro
Organizer
Annual Congress of American Heart Association
Place of Presentation
Orlando, USA
Year and Date
2011-11-16
Related Report
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[Presentation] on behalf of Osaka Acute Coronary Insufficiency Study (OACIS) Group. Incidence, Predictors, and Long-Term Mortality of Recurrent Myocardial Infarction in Patients following Discharge for Acute Myocardial Infarction2011
Author(s)
Daisaku Nakatani, Yasuhiko Sakata, Shinichiro Suna, Masaya Usamai, Sen Matsumoto, Toshimitsu Hamasaki, Hiroshi Sato, Masatsugu Hori, Shinsuke Nanto, Issei Komuro
Organizer
Annual Congress of American Heart Association
Place of Presentation
Orlando, USA.
Year and Date
2011-11-16
Related Report
