| Project/Area Number |
22590827
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Osaka University |
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Principal Investigator |
SAKATA Yasuhiko 大阪大学, 大学院・医学系研究科, 助教 (90379206)
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| Co-Investigator(Kenkyū-buntansha) |
中谷 大作 大阪大学, 医学系研究科, 研究員 (60444535)
砂 真一郎 大阪大学, 歯学研究科, 助教 (40573085)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分子血管病態学 / 心筋梗塞 / 高血圧 / 遺伝子多型 / アンジオテンシン / マクロファージ / 動脈硬化 / マイクロRNA / リンホトキシンα |
|---|
| Research Abstract |
We tried to Identify microRNAs involved in f ormation of foam cells that are associated with atherosclerosis-related gene lymphotoxin-alpha (LTA). However, we found that LTA was unlikely involved in foam cell formation. Thus, we changed our plan and identified microRNAs that are associated with cardiac death in patients who survived acute myocardial infarction, a major cause of death as a result of atherosclerotic diseases.
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