| Project/Area Number |
22590839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yutaka 京都大学, 医学(系)研究科(研究院), 助教 (80362482)
HIRATA Yutaka 兵庫医科大学, 医学部, 講師 (10441247)
OKU Yoshitaka 兵庫医科大学, 医学部, 教授 (20252512)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 難治性気道疾患 / キチナーゼ関連タンパク質 / 喘息 / YKL-40 / 気道ﾘﾓﾃﾞﾘﾝｸﾞ / 慢性炎症性気道疾患 / アレルギー・喘息 / キチナーゼ関連蛋白質 / ステロイド低感受性 / 気道過分泌 / 加齢 |
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| Research Abstract |
The mechanisms underlying airway remodeling accompanying with non-eosinophilic airway inflammation remain unclear. Chitinase-like protein, YKL-40 that is also known as age-related protein, is produced from various cells including airway epithelial cells, neutrophils, and macrophages. This study demonstrated that YKL-40 accelerates proliferation of cultured airway smooth muscle cells and may also alter the proportion of extracellular matrix. Thus YKL-40 may be involved in the pathogenesis of airway remodeling in elderly patients with asthma or COPD, where non-eosinophilic airway inflammation is predominant.
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