Role of chitinase like protein in chronic inflammatory airway diseases

• Project/Area Number: 22590839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: MATSUMOTO Hisako 京都大学, 医学研究科, 助教 (60359809)
• Co-Investigator(Kenkyū-buntansha): ITO Yutaka 京都大学, 医学(系)研究科(研究院), 助教 (80362482) ; HIRATA Yutaka 兵庫医科大学, 医学部, 講師 (10441247) ; OKU Yoshitaka 兵庫医科大学, 医学部, 教授 (20252512)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 難治性気道疾患 / キチナーゼ関連タンパク質 / 喘息 / YKL-40 / 気道ﾘﾓﾃﾞﾘﾝｸﾞ / 慢性炎症性気道疾患 / アレルギー・喘息 / キチナーゼ関連蛋白質 / ステロイド低感受性 / 気道過分泌 / 加齢

Research Abstract

The mechanisms underlying airway remodeling accompanying with non-eosinophilic airway inflammation remain unclear. Chitinase-like protein, YKL-40 that is also known as age-related protein, is produced from various cells including airway epithelial cells, neutrophils, and macrophages. This study demonstrated that YKL-40 accelerates proliferation of cultured airway smooth muscle cells and may also alter the proportion of extracellular matrix. Thus YKL-40 may be involved in the pathogenesis of airway remodeling in elderly patients with asthma or COPD, where non-eosinophilic airway inflammation is predominant.

Research Products

• [Journal Article] Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma (2013)
  • Author(s): Nakaji H, Petrova G, Matsumoto H, Iwata T, Ito I, Oguma T, Inoue H, Tajiri T, Nagasaki T, Kanemitsu Y, Niimi A, Misima M
  • Journal Title: Ann Allergy Asthma Immunol Volume: 110 Pages: 198-203
  • NAID: 120005244569
• [Journal Article] Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation (2013)
  • Author(s): Nagasaki T, Matsumoto H, et al
  • Journal Title: Clin Exp Allergy Volume: 43 Issue: 6 Pages: 608-15
  • DOI: 10.1111/cea.12073
  • Peer Reviewed
• [Journal Article] Increased periostin associates with greater ariflow limitation in paitents receiving inhaled corticosteroids (2013)
  • Author(s): Kanemitsu, Matsumoto, et al.
  • Journal Title: J Allergy Clin Immunol Volume: 未
  • Peer Reviewed
• [Journal Article] Efficacy of omalizumab in eosinophilic chronic rhinosinusitis patients with asthma. (2013)
  • Author(s): Tajiri, Matsumoto, et al.
  • Journal Title: Ann Allergy Asthma Immunol Volume: 未
  • Peer Reviewed
• [Journal Article] Influences of smoking and aging on allergic airway inflammation in asthma (2013)
  • Author(s): Nagasaki, Matsumoto.
  • Journal Title: Allergol Int Volume: 未
  • NAID: 130004873077
  • Peer Reviewed
• [Journal Article] Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation (2013)
  • Author(s): Nagasaki, Matsumoto, et al.
  • Journal Title: Clin Exp Allergy Volume: 未
  • Peer Reviewed
• [Journal Article] Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma (2013)
  • Author(s): Nakaji, Petrova, Matsumoto, et al.
  • Journal Title: Ann Allergy Asthma Immunol Volume: 未
  • NAID: 120005244569
  • Peer Reviewed
• [Journal Article] Interleukin-13 enhanced Ca2+oscillations in airway smooth muscle cells (2012)
  • Author(s): Matsumoto H, Hirata Y, Oku Y. et al
  • Journal Title: Cytokine Volume: 57 Pages: 19-24
  • NAID: 120003726117
• [Journal Article] Sputum YKL-40 levels and pathophysiology of asthma and chronic obstructive pulmonary disease (2012)
  • Author(s): Otsuka K, Matsumoto H, et al
  • Journal Title: Respiration Volume: 83 Pages: 507-19
  • NAID: 120004397864
• [Journal Article] Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells (2012)
  • Author(s): Matsumoto, Hirata, et al.
  • Journal Title: Cytokine Volume: 57 Pages: 19-24
  • NAID: 120003726117
  • Peer Reviewed
• [Journal Article] Cough triggers and their pathophysiology in patients with prolonged or chronic cough (2012)
  • Author(s): Matsumoto H, et al
  • Journal Title: Allergol Int Volume: 61 Pages: 123-32
  • NAID: 130004873029
  • Peer Reviewed
• [Journal Article] Sputum YKL-40 levels and pathophysiology of asthma and chronic obstructive pulmonary disease (2011)
  • Author(s): Otsuka K, Matsumoto H, et al
  • Journal Title: Respiration Volume: (E-pub ahead of print) Issue: 6 Pages: 507-519
  • DOI: 10.1159/000330840
  • NAID: 120004397864
  • Peer Reviewed
• [Journal Article] Plasma substance P levels in patients with persistent cough (2011)
  • Author(s): Otsuka K, Niimi A, Matsumoto H, et
  • Journal Title: Respiration Volume: 82 Issue: 5 Pages: 431-8
  • DOI: 10.1159/000330419
  • NAID: 120003534358
  • Peer Reviewed
• [Journal Article] Long-term changes in airway-wall thickness on computed tomography in asthmatic patients. (2011)
  • Author(s): Matsumoto H, et al.
  • Journal Title: J Investig Allergol Clin Immunol Volume: 21 Pages: 113-119
  • Peer Reviewed
• [Journal Article] Eosinophils and macrophages are involved in nitrosative stress in chronic eosinophilic pneumonia. (2011)
  • Author(s): Nakaji H, Matsumoto H, et al.
  • Journal Title: Nitric Oxide Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Association of alveolar nitric oxide levels with pulmonary function and its reversibility in stable asthma. (2011)
  • Author(s): Matsumoto H, et al
  • Journal Title: Respiration Volume: 81 Pages: 311-317
  • NAID: 120005593637
  • Peer Reviewed
• [Journal Article] Inflammatory subtypes in cough-variant asthma : association with maintenance doses of inhaled corticosteroids. (2010)
  • Author(s): Matsuoka H, et al
  • Journal Title: Chest Volume: 138 Pages: 1418-1425
  • Peer Reviewed
• [Journal Article] Tazobactam/piperacillin for moderate-to-severe pneumonia in patients with risk for aspiration : comparison with imipenem/cilastatin (2010)
  • Author(s): Ito I, et al
  • Journal Title: Pulm Pharmacol Ther Volume: 23 Pages: 403-410
  • Peer Reviewed
• [Journal Article] Association of eosinophilic inflammation with FKBP51 expression in sputum cells in asthma
  • Author(s): Tajiri T, Matsumoto H, et al
  • Journal Title: PLOS one
  • NAID: 120005296109
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids
  • Author(s): Kanemitsu Y, Matsumoto H, et al
  • Journal Title: J Allergy Clin Immunol
  • NAID: 120005342661
• [Presentation] Serum YKL-40 levels in asthma : Longitudinal relations with pathophysiology of (2011)
  • Author(s): Otsuka K, Matsumoto H, et al
  • Organizer: American Thoracic Society
  • Place of Presentation: Denver, Colorad, US
  • Year and Date: 2011-05-17
• [Presentation] 吸入ステロイド治療前後における血清YKL40値と喘息病態との関係 (2010)
  • Author(s): 大塚浩二郎
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-11-26
• [Presentation] Associations of asthma control status with inflammatory biomarkers: "Shortness of breath" and serum YKL-40 levels
  • Author(s): H. Nakaji, H. Matsumoto, A. Niimi, I. Ito, H. Inoue, T. Iwata, T. Oguma, T. Tajiri, T. Nagasaki, M. Mishima
  • Organizer: 2012 American Thoracic Society
• [Presentation] Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma
  • Author(s): Matsumoto H, Nakaji H, Petrova G, Iwata T, Ito I, Oguma T, Inoue H, Tajiri T, Nagasaki T, Kanemitsu Y, Niimi A, Misima M
  • Organizer: 2013 American Thoracic Society
• [Book] "Calcium Signaling In Airway Smooth Muscle Cells". Yong-Xiao Wang ed. (2013)
  • Author(s): Matsumoto H.
  • Publisher: Springer
• [Book] 喘息(改訂第2版) (2011)
  • Author(s): 松本久子(泉英孝編)
  • Publisher: 最新医学