Osteopontin in the pathogenesis of acute eosinophilic pneumonia
| Project/Area Number |
22590866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Masaru 大分大学, 医学部, 講師 (20336267)
NUREKI Shin-ichi 大分大学, 医学部, 助教 (50423702)
ISHII Toshihiro 大分大学, 医学部, 助教 (00528911)
小野 恵美子 大分大学, 医学部, 医員 (20416051)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | オステオポンチン / 急性好酸球性肺炎 / 好酸球 / ケモカイン / Th2/Th2 / バイオマーカー / Th1/Th2 / サイトカインネットワーク / CCL19 / 好酸球性肺炎 / TSLP / 免疫蛍光二重染色 / 気管支肺胞洗浄液 |
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| Research Abstract |
The present study demonstrated that osteopontin was significantly elevated in BALF from patients with acute eosinophilic pneumonia as well as other types of eosinophilic pneumonia. This suggests that osteopontin elevation may be associated with eosinophilic inflammation. The concentration of osteopontin was correlated with that of several cytokines and chemokines, which induce eosinophilic inflammation. Double immunofluorescence labeling showed that osteopontin was expressed in lung eosinophils.Osteopontin may contribute to the development of eosinophilic inflammation in patients with acute eosinophilic pneumonia.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment2011
Author(s)
Azuma A, Taguchi Y, Ogura T, Ebina M, Taniguchi H, Kondoh Y, Suga M, Takahashi H, Nakata K, Sato A, Kudoh S, Nukiwa T
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Journal Title
Respir Res
Volume: 12
Issue: 1
Pages: 143-143
DOI
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Peer Reviewed
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[Presentation]2010
Author(s)
山末まり、 宮崎英士、他
Organizer
第50回日本呼吸器学会学術講演会
Place of Presentation
東京
Related Report
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