Development of a new immunosuppressive therapy using adipose derived mesenchymal stem cell

• Project/Area Number: 22590887
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: OZAKI Takenori 名古屋大学, 医学部附属病院, 病院助教 (10452195)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Shoichi 名古屋大学, 大学院・医学系研究科, 准教授 (10362253) ; YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479)
• Co-Investigator(Renkei-kenkyūsha): KOBAYASHI Takaaki 名古屋大学, 大学院・医学系研究科, 寄附講座教授 (70314010)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 脂肪由来間葉系幹細胞 / 低血清培養 / 抗糸球体基底膜抗体腎炎 / 強皮症 / M2 マクロファージ / M2マクロファージ / 間葉系幹細胞 / 脂肪 / 低血清培養法 / 抗体産生抑制

Research Abstract

We clarified that administration of low serum cultured adipose derived mesenchymal stem cells (MSCs) showed therapeutic effect on animal models including rat anti-GBM glomerulonephritis and mouse systemic sclerosis. We demonstrated that low serum cultured adipose derived MSCs may exert immnosuppressive effect by inducing M2 macrophages. We also found that low serum cultured adipose derived MSCs did not promote malignant tumorigenesis and administration of 7×10^7/kg cells was safe.

Research Products

• [Journal Article] Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats. (2013)
  • Author(s): Katsuno T
  • Journal Title: Cell Transplant Volume: 22(2) Issue: 2 Pages: 287-97
  • DOI: 10.3727/096368912x655019
  • Peer Reviewed
• [Journal Article] Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats (2012)
  • Author(s): Ozaki T, Tsuboi N, Mizuno M, Matsuo S, Maruyama S.
  • Journal Title: Cell Transplant
  • Peer Reviewed
• [Journal Article] Efficacy and safety of human adiposetissue-derived mesenchymal stem cells for supporting hematopoiesis (2012)
  • Author(s): Nishiwaki S, Ozaki T, Maruyama S, Nishida T.
  • Journal Title: Int J Hematol Volume: 96(3) Pages: 295-300
  • Peer Reviewed
• [Journal Article] Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis. (2012)
  • Author(s): Nishiwaki S
  • Journal Title: Int J Hematol. Volume: 96(3) Issue: 3 Pages: 295-300
  • DOI: 10.1007/s12185-012-1140-8
  • Peer Reviewed
• [Journal Article] Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production (2011)
  • Author(s): Saka Y, Ozaki T, Sato W, Tsuboi N, Ito Y, Matsuo S, Kobayashi T, Maruyama S.
  • Journal Title: Xenotransplantation. Volume: 18(3) Pages: 196-208
  • Peer Reviewed
• [Journal Article] Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin (2011)
  • Author(s): Kato K
  • Journal Title: Clin Exp Nephrol Volume: 15(3) Pages: 346-54
  • Peer Reviewed
• [Journal Article] A Case of Fulminant Peritonitis Caused by Streptococcus mitis in a Patient on Peritoneal Dialysis (2011)
  • Author(s): Mizuno M
  • Journal Title: Intern Med Volume: 50(16) Pages: 1719-23
  • Peer Reviewed
• [Journal Article] Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production (2011)
  • Author(s): Saka Y
  • Journal Title: Xenotransplantation Volume: 18(3) Pages: 196-208
  • Peer Reviewed
• [Journal Article] Increased urethral resistance by periurethral injection of low serum cultured adipose-derived mesenchymal stromal cells in rats (2011)
  • Author(s): Watanabe T
  • Journal Title: Int J Urol Volume: 18(9) Issue: 9 Pages: 659-66
  • DOI: 10.1111/j.1442-2042.2011.02795.x
  • Peer Reviewed
• [Journal Article] A Case of Acute Renal Failure Caused by Cholesterol Embolization after Carotid Artery Stenting that was Improved by Peritoneal Dialysis (2011)
  • Author(s): Mizuno M
  • Journal Title: Intern Med Volume: 50(16) Pages: 1719-23
  • Peer Reviewed
• [Journal Article] Low-serum culture system improves the adipogenic ability of visceral adipose tissue-derived stromal cells (2011)
  • Author(s): Nagasaki H
  • Journal Title: Cell Biol Int Volume: 35(6) Pages: 559-68
  • Peer Reviewed
• [Journal Article] Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis (2011)
  • Author(s): Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S
  • Journal Title: Nephrol.Dial.Tranplant. Volume: 27(6) Issue: 6 Pages: 2511-6
  • DOI: 10.1093/ndt/gfr685
  • Peer Reviewed
• [Journal Article] Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis (2010)
  • Author(s): Maruyama S, Ozaki T, Nickenig G, Werner N.
  • Journal Title: PLoS One Volume: 5(7)
  • Peer Reviewed
• [Journal Article] Circulating progenitor cell count for cardiovascular risk stratification : apooled analysis. (2010)
  • Author(s): Fadini GP
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia. (2010)
  • Author(s): Yuzawa Y
  • Journal Title: Internal Medicine Volume: 49 Pages: 1139-42
  • NAID: 130000251642
  • Peer Reviewed
• [Presentation] Low Serum Cultured Adipose-Derived Mesenchymal Stromal Cells Ameliorate Rat Model with Zymosan Induced Severe Peritonitis (2012)
  • Author(s): 金恒秀
  • Organizer: 45rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-11-03
• [Presentation] 腹膜擦過後の Zymosan 投与により誘導される補体依存腹膜炎モデルに対する低血清培養脂肪由来間葉系幹細胞の有用性 (2012)
  • Author(s): 金恒秀
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2012-06-22
• [Presentation] LOW SERUM CULTURED ADIPOSE-DERIVED MESENCHYMAL STROMAL CELLS AMELIORATE RAT MODEL WITH ZYMOSAN INDUCED SEVERE PERITONITIS (2012)
  • Author(s): 金恒秀
  • Organizer: nternational Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-13
• [Presentation] POTENTIAL OF ADIPOSE-DERIVED STEM CELLS FROM HUMAN/RAT/MOUSE AS A NEW TOOL FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (2012)
  • Author(s): 丸山彰一
  • Organizer: nternational Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-13
• [Presentation] Low Serum Cultured Adipose-derived Mesenchymal Stem Cells Ameliorate Crescentic Glomerulonephritis by Functional Polarization of Macrophages into Immunoregulatory M2 Phenotype (2012)
  • Author(s): 古橋和拡
  • Organizer: The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012(AP-VAS)
  • Place of Presentation: 東京
  • Year and Date: 2012-03-29
• [Presentation] Evaluation of Diverticular Diseases by Computed Tomography Is Useful for Selection of Peritoneal Dialysis Modality and Asymptomatic Diverticulosis Is Not a Risk Factor for Peritonitis (2011)
  • Author(s): Yasuhiko Ito
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-12
• [Presentation] Low Serum Cultured Adipose Derived Stem Cells Ameliorate Zymosan Induced Severe Rat Peritonitis Model (2011)
  • Author(s): 金恒秀
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-10
• [Presentation] Low Serum Cultured Adipose-Derived Mesenchymal Stem Cells, but Not Bone-Marrow Derived Mesenchymal Stem Cells, Ameliorate Rat Crescentic Glomerulonephritis by Functional Polarization of Macrophages into Immunoregulatory Phenotype (2011)
  • Author(s): 古橋和拡
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-10
• [Presentation] 慢性腎臓病患者におけるHMG-CoA還元酵素阻害薬(ピタバスタチン)の腎機能に及ぼす影響の検討(P-STAR-CKD) (2011)
  • Author(s): 安田宜成
  • Organizer: 第41回日本腎臓学会西部学術総会
  • Place of Presentation: 徳島(徳島県郷土文化会館)
  • Year and Date: 2011-10-01
• [Presentation] 組織学的に診断された重度腎孟腎炎合併移植腎の1症例 (2011)
  • Author(s): 伊藤裕紀子
  • Organizer: 第41回日本腎臓学会西部学術総会
  • Place of Presentation: 徳島(徳島県郷土文化会館)
  • Year and Date: 2011-10-01
• [Presentation] 糸球体病変を欠くANCA関連腎炎の2症例 (2011)
  • Author(s): 野中慶佑
  • Organizer: 第41回日本腎臓学会西部学術総会
  • Place of Presentation: 徳島(徳島県郷土文化会館)
  • Year and Date: 2011-10-01
• [Presentation] 脂肪由来間葉系幹細胞を用いた壊死性半月体形成腎炎への新たな治療法の確立～骨髄由来間葉系細胞にはなく塩脂肪由来幹細胞がもつ Macrophage への unique chaqracter～ (2011)
  • Author(s): 古橋和拡
  • Organizer: 第三回腎疾患と高血圧研究会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-27
• [Presentation] 脂肪由来間葉系幹細胞を用いた壊死性半月体形成腎炎への新たな治療法の確立～骨髄由来間葉系細胞にはなく塩脂肪由来幹細胞がもつMacrophageへのunique chaqracter～ (2011)
  • Author(s): 古橋和拡
  • Organizer: 第三回腎疾患と高血圧研究会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-27
• [Presentation] 多肢趾壊死を伴ったコレステロール塞栓症による腎不全に対して腹膜透析を選択した一例 (2011)
  • Author(s): 早崎貴洋
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-18
• [Presentation] 異物によるS状結腸穿孔から汎発性腹膜炎をきたしたCAPD患者の一例 (2011)
  • Author(s): 中島諒子
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-18
• [Presentation] Zymosan による高度炎症の腹膜炎モデルに対する低血清培養脂肪由来間葉系幹細胞(LASC)の効果 (2011)
  • Author(s): 金恒秀
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 脂肪由来間葉系幹細胞を用いた難治性腎疾患への新たな治療戦略 (2011)
  • Author(s): 古橋和拡
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 脂肪由来間葉系幹細胞を用いた難治性腎疾患への新たな治療戦略 (2011)
  • Author(s): 古橋和拡
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] Zymosanによる高度炎症の腹膜炎モデルに対する低血清培養脂肪由来間葉系幹細胞(LASC)の効果 (2011)
  • Author(s): 金恒秀
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] Oxaliplatinにより自己免疫性溶血性貧血・血小板減少を伴うAKIを来した1例 (2011)
  • Author(s): 伊藤功
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 疣贅PCRによりStaphylococcus warneriを起因菌と同定できた感染性心内膜炎の1例 (2011)
  • Author(s): 伊藤功
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 脂肪細胞由来幹細胞は腎臓をどう守るのか (2011)
  • Author(s): 丸山彰一
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-15
• [Presentation] IgA患者におけるPozziらのステロイドパルス療法の有効性 (2011)
  • Author(s): 立松美穂
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-15
• [Presentation] 脂肪由来間葉系幹細胞(ASC)を用いた難治性腎疾患・自己免疫疾患に対する新たな治療戦略 (2011)
  • Author(s): 古橋和拡
  • Organizer: 再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-02
• [Presentation] 脂肪由来間葉系幹細胞(ASC)を用いた難治性腎疾患・自己免疫疾患に対する新たな治療戦略 (2011)
  • Author(s): 古橋和拡
  • Organizer: 再生医療学会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2011-03-02
• [Presentation] Therapeutic Potential of Adipose-Derived Stem Cells for Anti-GBM Glomerulonephritis (2010)
  • Author(s): Kazuhiro Furuhashi
  • Organizer: 42rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Colorado Convention Center Denver, CO
  • Year and Date: 2010-12-20
• [Presentation] Knock-Down of HGF and VEGF Production Reduces the Renoprotective Effects of Adipose-Derived Stromal Cells in the Acute Kidney Injury (2010)
  • Author(s): Takayuki Katsuno
  • Organizer: 42rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Colorado Convention Center Denver, CO
  • Year and Date: 2010-12-19
• [Presentation] Association of CD34+ Circulating Progenitor Cells and C-Reactive Prote in with Cardiovascular and All-Cause Mortality in Hemodialysis Patients (2010)
  • Author(s): Shoichi Maruyama
  • Organizer: 42rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Colorado Convention Center Denver, CO
  • Year and Date: 2010-12-18
• [Presentation] Therapeutic Potential of Adipose-Derived Stem Cells for Anti-GBM Glomerulonephritis (2010)
  • Author(s): 古橋和拡
  • Organizer: 43rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Denver.co
  • Year and Date: 2010-11-20
• [Presentation] Knock-Down of HGF and VEGF Production Reduces the Renoprotective Effects of Adipose-Derived Stromal Cells in the Acute Kidney Injury (2010)
  • Author(s): 勝野敬之
  • Organizer: 43rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Denver.co
  • Year and Date: 2010-11-19
• [Presentation] Tuener症候群と馬蹄腎の患者に合併した抗基底膜抗体型腎炎の一例 (2010)
  • Author(s): 佐藤和一
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-09
• [Presentation] リツキシマブが有効であったクリオグロブリン血症の一例 (2010)
  • Author(s): 早崎貴洋
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-09
• [Presentation] VEGF receptor2特異的結合性VEGF-Aの強発現は腎障害を引き起こす (2010)
  • Author(s): 小杉智規
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-08
• [Presentation] クリオグロブリン血症を伴いゲムシタビン誘発TMAをきたした一例 (2010)
  • Author(s): 立松美穂
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-08
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞を用いた骨粗鬆症モデルマウスに対する治療効果 (2010)
  • Author(s): 丸山彰一
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] 脂肪由来間葉系細胞による移植抗原に対する抗体産生抑制効果 (2010)
  • Author(s): 丸山彰一
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] Therapeutic Potential of Adipose-Derived Stem Cells for anti-GBM Glomerulone phritis (2010)
  • Author(s): 古橋和拡
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-08-05
• [Presentation] Therapeutic potential of adipose-derived stem cells for anti-GBM glomerulonephritis (2010)
  • Author(s): 古橋和拡
  • Organizer: 7th International Conference on Innate Immunity
  • Place of Presentation: ギリシャ
  • Year and Date: 2010-07-04
• [Presentation] 原因同定困難な腹膜炎の一例 (2010)
  • Author(s): 戸田晋
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-06-19
• [Presentation] 急速な病勢増悪を認めたαstreptococcusによるCAPD腹膜炎の一例 (2010)
  • Author(s): 増田智広
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-06-19
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞の腎保護効果とそのメカニズム (2010)
  • Author(s): 勝野敬之
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-18
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞の腎保護効果とそのメカニズム (2010)
  • Author(s): 勝野敬之
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-06-18
• [Presentation] 慢性透析患者におけるCD34陽性細胞数の減少は心血管予後不良予測因子である～4年間の前向きコホート研究～ (2010)
  • Author(s): 丸山彰一
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸商工会議所会館
  • Year and Date: 2010-06-18
• [Presentation] 脂肪由来間葉系幹細胞による Goodpastue disease モデルへの治療効果の検討 (2010)
  • Author(s): 古橋和拡
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] 脂肪由来間葉系細胞による移植抗原に対する抗体産生の抑制効果 (2010)
  • Author(s): 坂洋祐
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] 超音波造影剤を用いた腎血流と腎機能との関連の検討 (2010)
  • Author(s): 尾崎 武徳
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] 超音波造影剤を用いた腎血流と腎機能との関連の検討 (2010)
  • Author(s): 尾崎武徳
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-06-17
• [Presentation] 脂肪由来間葉系細胞による移植抗原に対する抗体産生の抑制効果 (2010)
  • Author(s): 坂洋祐
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-06-17
• [Presentation] 脂肪由来間葉系幹細胞によるGoodpastue diseaseモデルへの治療効果の検討 (2010)
  • Author(s): 古橋和拡
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-06-17
• [Presentation] Adipose-derived stem cells therapy iS effective in the treatment of anti-GBM glomerulonephritis. (2010)
  • Author(s): Kazuhiro Furuhashi
  • Organizer: APCN 2010
  • Place of Presentation: Convention and Exhibition Center (COEX), Seoul, Korea
  • Year and Date: 2010-06-07
• [Presentation] RENOPROTECTIVE EFFECTS AND MECHANISMS OF HUMAN ADIPOSE TISSUE-DERIVED S TROMALCELLS CULTURED IN LOW SERUM MEDIA ON ACUTE KIDNEY INJURY (2010)
  • Author(s): 勝野敬之
  • Organizer: APCN 2010
  • Place of Presentation: Convention and Exhibition Center (COEX), Seoul, Korea
  • Year and Date: 2010-06-07
• [Presentation] RENOPROTECTIVE EFFECTS AND MECHANISMS OF HUMAN ADIPOSE TISSUE-DERIVED S TROMALCELLS CULTURED IN LOW SERUM MEDIA ON ACUTE KIDNEY INJURY (2010)
  • Author(s): 勝野敬之
  • Organizer: APCN 2010
  • Place of Presentation: Korea
  • Year and Date: 2010-06-06
• [Presentation] Adipose-derived stem cells therapy is effective in the treatment of anti-GBM glomerulonephritis (2010)
  • Author(s): 古橋和拡
  • Organizer: APCN 2010
  • Place of Presentation: Korea
  • Year and Date: 2010-06-06
• [Presentation] 肺胞出血を繰り返したSLEの1例 (2010)
  • Author(s): 増田智広
  • Organizer: 第54回日本リウマチ学会総会・学術大会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-04-22
• [Presentation] Adipose-derived stem cells therapy is effective in the treatment of anti-GBM glomerulonephritis (2010)
  • Author(s): 古橋和拡
  • Organizer: ISN nexus
  • Place of Presentation: 京都
  • Year and Date: 2010-04-17
• [Presentation] Renoprotective effects of human adiposetissue-derived stromal cells cultured in low serum media on acute kidney injury (2010)
  • Author(s): 勝野敬之
  • Organizer: ISN nexus
  • Place of Presentation: 京都
  • Year and Date: 2010-04-17
• [Presentation] Adipose-derived mesenchymal stem cells suppress antibody production against graft antigens (2010)
  • Author(s): 洋祐
  • Organizer: ISN nexus
  • Place of Presentation: 京都
  • Year and Date: 2010-04-17
• [Presentation] Adipose-derived mesenchymal stem cells suppress antibody production against graft antigens (2010)
  • Author(s): Yosuke-Saka
  • Organizer: ISN nexus
  • Place of Presentation: 京都国際会議センター(ICC京都府)
  • Year and Date: 2010-04-17
• [Presentation] Renoprotective effects of human adiposetissue-derived stromal cells cultured in low serum media on acute kidney injury (2010)
  • Author(s): Takayuki Katsuno
  • Organizer: ISN nexus
  • Place of Presentation: 京都国際会議センター(ICC京都府)
  • Year and Date: 2010-04-17
• [Presentation] Adipose-derived stem cells therapy is effective in the treatment of anti-GBM glomerulonephritis (2010)
  • Author(s): Kazuhiro Furuhashi
  • Organizer: ISN nexus
  • Place of Presentation: 京都国際会議センター(ICC京都府)
  • Year and Date: 2010-04-17
• [Presentation] Reduced number of circulating CD34-positivecells is associated with poor cardiovascular outcomes in chronic hemodialysis patients (2010)
  • Author(s): Shoichi Maruyama
  • Organizer: ISN nexus
  • Place of Presentation: 京都国際会議センター(ICC京都府)
  • Year and Date: 2010-04-17
• [Presentation] Malnutrition and chonic inflammation status at initiating phase of hemodialysis can stratify the risk of cardiovascular and all-cause moetality in CKD stage5 patients-10-year follow-up study (2010)
  • Author(s): Ryo Takahashi
  • Organizer: ISN nexus
  • Place of Presentation: 京都国際会議センター(ICC京都府)
  • Year and Date: 2010-04-17
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞の急性腎障害抑制効果 (2010)
  • Author(s): 勝野敬之
  • Organizer: 第9回日本再生医療学会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] Goodpasture disease モデルに対して脂肪由来幹細胞を用いた治療効果の検討 (2010)
  • Author(s): 古橋和拡
  • Organizer: 第9回日本再生医療学会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 脂肪由来間葉系細胞による移植抗原に対する抗体産生抑制効果 (2010)
  • Author(s): 丸山彰一
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] 腎再生療法における低血清培養脂肪組織由来間葉系細胞の有用性 (2010)
  • Author(s): 勝野敬之
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞を用いた骨粗霧症モデルマウスに対する治療効果 (2010)
  • Author(s): 丸山彰一
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] LOW SERUM CULTURED ADIPOSE-DERIVED MESENCHYMAL STROMAL CELLS AMELIORATE RAT MODEL WITH ZYMOSAN INDUCED SEVERE PERITONITIS
  • Author(s): 金恒秀
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] POTENTIAL OF ADIPOSE-DERIVED STEM CELLS FROM HUMAN/RAT/MOUSE AS A NEW TOOL FOR THE TREATMENT OF SYSTEMIC SCLEROSIS
  • Author(s): 丸山彰一
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] 腹膜擦過後のZymosan投与により誘導される補体依存腹膜炎モデルに対する低血清培養脂肪由来間葉系幹細胞の有用性
  • Author(s): 金恒秀
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌市教育文化会館(札幌)
• [Patent(Industrial Property Rights)] 脂肪組織由来間葉系幹細胞含有する免疫抑制剤及びその用途 (2012)
  • Inventor(s): 丸山彰一、尾崎武徳、坂洋祐、古橋和拡、坪井直毅
  • Industrial Property Rights Holder: 名古屋大学
  • Acquisition Date: 2012-02-17
• [Patent(Industrial Property Rights)] 脂肪組織由来間葉系肝細胞を含有する免疫抑制剤及びその用途 (2012)
  • Inventor(s): 丸山彰一、尾崎武徳、坂洋祐、古橋和拡、坪井直毅
  • Industrial Property Rights Holder: 丸山彰一、尾崎武徳、坂洋祐、古橋和拡、坪井直毅
  • Filing Date: 2012-02-17
  • Acquisition Date: 2012-02-28