Pathophysiological relevance of visceral fat and kidneys in obesity-induced renal injury
| Project/Area Number |
22590898
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Koichi 慶應義塾大学, 医学部, 准教授 (80164937)
WAKINO Shu 慶應義塾大学, 医学部, 講師 (50265823)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | Rhoキナーゼ / アルドステロン / 肥満 / メタボリックシンドローム / 脂肪組織 / ミネラルコルチコイド受容体 / 脂肪腎臓連関 / 尿細管細胞肥大 |
|---|
| Research Abstract |
Excess fat intake causes obesity and renal injury in C57BL/6J mice, and these changes are mediated by an enhanced mineralocorticoid receptor /Rho/Rho-kinase pathway and inflammatory process. Moreover, the removal of visceral fat pads resulted in marked de
|
Report
(4 results)
Research Products
(25 results)
-
[Journal Article] The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.2013
Author(s)
Hasegawa K, Wakino S, Kimoto M, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Tokuyama H, Hayashi K, Itoh H.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Role of Mineralocorticoid receptor/Rho/Rho-kinase pathway in Obesity-Related Renal Injury.2012
Author(s)
Tokuyama H, Wakino S, Hara Y, Washida N, Fujimura K, Hosoya K, Yoshioka K, Hasegawa K, Minakuchi H, Homma K, Hayashi K, Itoh H.
-
Journal Title
Int J Obes (Lond)
Volume: 36(8)
Pages: 1062-71
Related Report
Peer Reviewed
-
[Journal Article] Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.2011
Author(s)
Washida N, Wakino S, Tonozuka Y, Homma K, Tokuyama H, Hara Y, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Itoh H.
-
Journal Title
Nephrol Dial Transplant.
Volume: 26(9)
Pages: 2770-2779
Related Report
Peer Reviewed
-
[Journal Article] Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch.2011
Author(s)
Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, Itoh H.
-
Journal Title
Sci Signal
Volume: 25;4(157)
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
