Therapeutic strategy for chronic kidney disease and hypertension based on time/metabolism regulation.
| Project/Area Number |
22590915
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WAKINO Shu 慶應義塾大学, 医学部, 専任講師 (50265823)
TOKUYAMA Hirobumi 慶應義塾大学, 医学部, 専任講師 (50276250)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 慢性腎臓病 / 高血圧 / 長寿遺伝子 / Sirt / 糖尿病 / 加齢 / 近位尿細管 / 腎障害 / 酸化ストレス / ミトコンドリア / 尿細管 / シスプラチン |
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| Research Abstract |
From the point of renal energy metabolism, cisplatin-induced proximal tubular injuries were abrogated by overexpressing Sirt1 specifically in mouse renal proximal tubules. In streptozotocin-induced diabetic mice, sirt1 expression in proximal tubules was s
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.2013
Author(s)
Hasegawa K, Wakino S, Kimoto M, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Tokuyama H, Hayashi K, Itoh H
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Journal Title
FASEB Journal
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Role of mineralocorticoid receptor/Rho/ Rho-kinase pathway in obesity-related renal injury.2012
Author(s)
Tokuyama H, Wakino S, Hara Y, Washida N, Fujimura K, Hosoya K, Yoshioka K, Hasegawa K, Minakuchi H, Homma K, Hayashi K, Itoh H
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Journal Title
International Journal of Obesity Research
Volume: 36(8)
Pages: 1062-1071
Related Report
Peer Reviewed
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[Journal Article] Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.2011
Author(s)
Washida N, Wakino S, Tonozuka Y, Homma K, Tokuyama H, Hara Y, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Itoh H
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Journal Title
Nephrology Dialysis &Transplantation
Volume: 26 (9)
Pages: 2770-2779
Related Report
Peer Reviewed
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[Journal Article] Rho and Rho-kinase activation in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.2011
Author(s)
Hara Y, Wakino S, Tanabe y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, Itoh H
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Journal Title
Science Signaling
Volume: 4(157)
Related Report
Peer Reviewed
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[Journal Article] Rho and Rho-kinase activation in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch2011
Author(s)
Hara Y, Wakino S, Tanabe y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, Itoh H
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Journal Title
Science Signaling
Volume: 4
Related Report
Peer Reviewed
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[Journal Article] Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis2011
Author(s)
Washida N, Wakino S, Tonozuka Y, Homma K, Tokuyama H, Hara Y, Hasegawa K, Minakuchi H, Fujimura K Hosoya K, Hayashi K, Itoh H
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Journal Title
Nephrology Dialysis & Transplantation
Volume: 26
Issue: 9
Pages: 2770-2779
DOI
Related Report
Peer Reviewed
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[Journal Article] Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function.2010
Author(s)
Hasegawa K, Wakino S, Yoshioka K, Tatematsu S, Hara Y, Minakuchi H, Sueyasu K, Washida N, Tokuyama H, Tzukerman M, Skorecki K, Hayashi K, Itoh H
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Journal Title
Journal of Biological Chemistry
Volume: 285(17)
Pages: 13045-13056
Related Report
Peer Reviewed
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