Development of regenerative medicine for spinal cord injury in HTLV-1 associated myelopathy
| Project/Area Number |
22590943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
YAMANO Yoshihisa 聖マリアンナ医科大学, 医学(系)研究科(研究院), 准教授 (80445882)
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| Co-Investigator(Kenkyū-buntansha) |
TOMARU Utano 北海道大学, 大学院・医学研究科, 准教授 (20360901)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経病態免疫学 / HAMの脊髄再生 / 再生医学 / HAM / HTLV-1 / 脂肪組織由来体性幹細胞 / 脊髄再生 |
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| Research Abstract |
We studied somatic stem cells in order to forward the development of regenerative medicine for spinal cord injury in Human T-Lymphotropic Virus Type 1 (HTLV-1) associated myelopathy (HAM). We investigated the infectiousness of HTLV-1 to somatic stem cells and used an animal model for HAM to analyze the regenerative capacity of somatic stem cells as a treatment option. We transplanted adipose derived somatic stem cells (ASCs) from HTLV-1 infected GFP rats into GFP-negative non-infected rats, and no infection was observed. However, when we analyzed the infectiousness to human-derived ASCs in vitro, we clearly observed infection, indicating that there is a risk that ASCs could become infected with HTLV-1. We also attempted to create an animal model of early-onset HAM using HTLV-1 infected rats by challenging the infection every 2 weeks; however, no acceleratory effect was observed. Finally, we analyzed the major pathogenic processes leading to spinal cord lesions in HAM, and we demonstrated that overproduction of CXCL10 from astrocytes plays a major role in HAM pathogenesis.
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Report
(4 results)
Research Products
(141 results)
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[Journal Article] Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes2011
Author(s)
Sato T, Konomi K, Fujii R, Aono H, Aratani S, Yagishita N, Araya N, Yudoh K, Beppu M, Yamano Y, Nishioka K, Nakajima T
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Journal Title
Ann Rheum Dis
Volume: 70
Issue: 1
Pages: 221-22
DOI
Related Report
Peer Reviewed
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[Journal Article] E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis2010
Author(s)
Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, Araya N, Koike J, Tadokoro M, Suzuki N, Nagata K, Senoo H, Friedman SL, Nishioka K, Yamano Y, Itoh F, Nakajima T
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Journal Title
PLoS One
Volume: 5
Issue: 10
Pages: e13590-e13590
DOI
Related Report
Peer Reviewed
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