Analysis of tissue accumulation and regulation of adiponectin
Project/Area Number |
22590979
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Osaka University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
船橋 徹 (舟橋 徹) 大阪大学, 医学(系)研究科(研究院), 教授 (60243234)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 内科 / 糖尿病 / 蛋白質 |
Research Abstract |
Adenovirus-mediated supplement of adiponectin to adiponectin-deficient mice demonstrated that adiponectin was accumulated in the heart tissue and exhibited cardio-protective role. S100A8 was identified as a novel adipocytokine from mice white adipose tissue by cDNA microarray analysis. Glucocorticoid was one of regulators for adiponectin expression and its regulatory mechanism was clarified in present study.
|
Report
(4 results)
Research Products
(56 results)
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[Journal Article] Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice2012
Author(s)
Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Maeda N, Sakaue H, Masuzaki H, Shimomura I, Sata M.
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Journal Title
Cardiovascular Diabetol.
Volume: 11
Issue: 1
Pages: 139-139
DOI
Related Report
Peer Reviewed
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[Journal Article] Adiponectin G276T gene polymorphism is associated with cardiovascular disease in Japanese patients with type 2 diabetes.2012
Author(s)
Katakami N, Kaneto H, Matsuoka TA, Takahara M, Maeda N, Shimizu I, Ohno K, Osonoi T, Kawai K, Ishibashi F, Imamura K, Kashiwagi A, Kawamori R, Matsuhisa M, Funahashi T, Yamasaki Y, Shimomura I.
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Journal Title
Atherosclerosis.
Volume: 220
Issue: 2
Pages: 437-442
DOI
Related Report
Peer Reviewed
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[Journal Article] Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference : a pilot study of obese Japanese patients with type 2 diabetes2011
Author(s)
Inoue K, Maeda N, Kashine S, Fujishima Y, Kozawa J, Hiuge-Shimizu A, Okita K, Imagawa A, Funahashi T, Shimomura I
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Journal Title
Cardiovasc Diabetol
Volume: 10
Issue: 1
Pages: 109-109
DOI
Related Report
Peer Reviewed
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[Journal Article] Induced adipocyte cell-sheet ameliorates cardiac dysfunction in a mouse myocardial infarction model: a novel drug delivery system for heart failure.2011
Author(s)
Imanishi Y, Miyagawa S, Maeda N, Fukushima S, Kitagawa-Sakakida S, Daimon T, Hirata A, Shimizu T, Okano T, Shimomura I, Sawa Y
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Journal Title
Circulation.
Volume: 124
Issue: 11_suppl_1
DOI
Related Report
Peer Reviewed
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[Journal Article] Right-Sided Acute Suppurative Thyroiditis Caused by Infectious Endocarditis2011
Author(s)
Inoue K, Kozawa J, Funahashi T, Nakata Y, Mitsui E, Kitamura T, Maeda N, Kishida,K, Otsuki M, Okita K, Iwahashi H, Imagawa A, Shimomura I
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Journal Title
Internal Medicine
Volume: 50
Issue: 23
Pages: 2893-2897
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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