| Project/Area Number |
22591017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
WAKINO Shu 慶應義塾大学, 医学部, 講師 (50265823)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
TANABE Yoshiyuki 岩手医科大学, 薬学部, 准教授 (10275109)
SAITO Maki 岩手医科大学, 薬学部, 助教 (40365185)
TOKUYAMA Hiroumi 慶應義塾大学, 医学部, 講師 (50276250)
HARA Yoshikazu 慶應義塾大学, 医学部, 助教 (30383863)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 内科 / シグナル伝達 / 肥満 / Rhoキナーゼ / 脂肪組織 |
|---|
| Research Abstract |
The development of obesity involves multiple mechanisms. Here we demonstrate adipocyte Rho/Rho-kinase as a culprit in obesity. In high fat diet (HFD)-fed mice, Rho-kinase inhibitor treatment prevented body weight gain and insulin resistance. Transgenic mi
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