Rescue of beta-cell function by transcription factors MafA and Pdx1
| Project/Area Number |
22591022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
NISHIMURA Wataru 独立行政法人国立国際医療研究センター, 糖尿病研究センター・代謝疾患研究部, 室長 (00334433)
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Kazuki 国立国際医療研究センター研究所, 糖尿病研究センター 代謝疾患研究部, 部長 (80311611)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 糖尿病 / 発現制御 / 遺伝子 / 細胞・組織 / 内分泌 / β細胞 / 膵臓 / 転写因子 |
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| Research Abstract |
Type 2 diabetes results from dysfunction of pancreatic β-cells. The expression of MafA is impaired in the compromised β-cells. The adult β-cell specific expression of MafA by the tetracycline-inducible system improved glucose intolerance of MafA knockout mice and high fat diet-fed (HFD) mice, and lowered fasting blood glucose of HFD mice. These results indicated that the expression of MafA can be a therapeutic target for diabetes.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Quantitative assessment of Pdx1 promoter activity in vivo using a secreted luciferase reporter system.
Author(s)
Nishimura W, Eto K, Miki A, Goto M, Kawaguchi M, Nammo T, Udagawa H, Hiramoto M, Shimizu Y, Okamura T, Fujiwara T, Yasuda Y, Yasuda K
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Peer Reviewed
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[Presentation] Luminez 法を用いた高度肥満症における減量手術前後の血清肥満関連項目の解析2012
Author(s)
井花庸子, 宇田川陽秀, 上番増喬, 平本正樹, 南茂隆生, 西村 渉, 本田律子, 関 洋介, 野田光彦, 笠間和典, 安田和基
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
横浜
Year and Date
2012-05-19
Related Report
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[Presentation] Luminez法を用いた高度肥満症における減量手術前後の血清肥満関連項目の解析.2012
Author(s)
井花庸子, 宇田川陽秀, 上番増喬, 平本正樹, 南茂隆生, 西村渉, 本田律子, 関洋介, 野田光彦, 笠間和典, 安田和基.
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
横浜
Year and Date
2012-05-19
Related Report
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[Presentation] Generation and Characterization of Pdx1-Gaussia luciferase mouse.2012
Author(s)
Nishimura W, Kawaguchi M, Eto K, Nammo T, Udagawa H, Uebanso T, Hiramoto M, Goto M, Shimizu Y, Okamura T, Yasuda K
Organizer
American Diabetes Assocation 72nd Scientific Sessions
Place of Presentation
Philadelphia, PA, USA
Related Report
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[Presentation] Generation and Characterization of Pdx1-Gaussia luciferase mouse. (Diabetes. 61 Suppl1 : 2087-P, 2012).2012
Author(s)
Nishimura W, Kawaguchi M, Eto K, Nammo T, Udagawa H, Uebanso T, Hiramoto M, Goto M, Shimizu Y, Okamura T, Yasuda K.
Organizer
American Diabetes Assocation 72nd Scientific Sessions
Place of Presentation
Philadelphia, PA, USA
Related Report
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