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Contribution of integrin in the pathogenesis ofrheumatoid arthritis

Research Project

Project/Area Number 22591076
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKobe University

Principal Investigator

KAWANO Seiji  神戸大学, 医学部附属病院, 特命准教授 (20351512)

Co-Investigator(Kenkyū-buntansha) NAKAMACHI Yuji  神戸大学, 医学部附属病院, 臨床検査技師 (80379429)
KASAGI Shimpei  神戸大学, 医学部附属病院, 特命助教 (80457051)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsマイクロ RNA / 関節リウマチ / インテグリン / マイクロRNA
Research Abstract

We investigated the roles of miRNA with regard to the regulation of beta1 integrin in the pathogenesis of rheumatoid arthiritis. We found that (1) Overexpression of miR-124 caused lower expression of beta1 integrin in RA synoviocyte cell line, (2) Injection of miR-124 ameliorated the arthritis and reduced beta-1 integrin expression in histological section of joints in rat adjuvant-induced arthritis model.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2013 2012 2011 2010

All Journal Article (26 results) (of which Peer Reviewed: 24 results) Presentation (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Quantitative Evaluation of Ventricular Dilatation using Computed Tomography in Infants with Congenital Cytomegalovirus Infection.2013

    • Author(s)
      Matsuo K
    • Journal Title

      Brain & Development.

      Volume: in press Issue: 1 Pages: 10-15

    • DOI

      10.1016/j.braindev.2012.12.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperdiploidy and duplication of der(11)ins(10;11)(p12;q23q14) in acute myeloid leukemia with MLL/MLLT10 fusion gene.2013

    • Author(s)
      Yamamoto K
    • Journal Title

      Leukemia and Lymphoma.

      Volume: in press Issue: 9 Pages: 2055-2058

    • DOI

      10.3109/10428194.2012.762094

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study2012

    • Author(s)
      Onishi A, Sugiyama D, Tsuji G, Nakazawa T, Kogata Y, Tsuda K, Naka I, Nishimura K, Misaki K, Kurimoto C, Hayashi H, Kageyama G, Saegusa J, Sugimoto T, Kawano S, Kumagai S, and Morinobu A
    • Journal Title

      Mod Rheumatol

    • NAID

      10031167670

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production2012

    • Author(s)
      Jauharoh SA, Saegusa J, Sugimoto T, Ardianto B, Kasagi S, Sugiyama D, Kurimoto C, Tokuno O, Nakamachi Y, Kumagai S, and Kawano S.
    • Journal Title

      Biochem Biophys Res Comm

      Volume: 417(1) Pages: 582-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Utility of Transmural Myocardial Strain Profile for Prediction of Early Left Ventricular Dysfunction in Patients with Duchenne Muscular Dystrophy.2012

    • Author(s)
      Yamamoto T
    • Journal Title

      American Journal of Carrdiology.

      Volume: 111 Issue: 6 Pages: 902-7

    • DOI

      10.1016/j.amjcard.2012.11.049

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fasting remnant lipoproteins can predict postprandial hyperlipidemia.2012

    • Author(s)
      Nagata T
    • Journal Title

      Lipids in Health and Disease.

      Volume: 11 Issue: 1 Pages: 146-146

    • DOI

      10.1186/1476-511x-11-146

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel treatment strategy for Japanese newborns with high serum unbound bilirubin levels.2012

    • Author(s)
      Yokota T
    • Journal Title

      Pediatric International.

      Volume: 55 Pages: 54-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trimethoprim-Sulfamethoxazole-Induced Hepatitis in Mixed Connective Tissue Disease.2011

    • Author(s)
      Sugimoto T, Nobuhara Y, Kawano S, and Morinobu A
    • Journal Title

      International Journal of Clinical Medicine

      Volume: 2 Pages: 629-632

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic Accuracy of Serum 1,3-β-D-Glucan Aspergillosis: Systematic Review and Meta-Analysis. for Pneumocystis Jiroveci Pneumonia, Invasive Candidiasis and Invasive aspergillosis: systematic review and meta-analysis2011

    • Author(s)
      Onishi A, Sugiyama D, Kogata Y, Saegusa J, Sugimoto T, Kawano S,Morinobu A, Nishimura K, and Kumagai S
    • Journal Title

      J Clin Microbiol

      Volume: 50(1) Pages: 7-15

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review2011

    • Author(s)
      Kasagi S, Kawano S, and Kumagai S. PD-1 and Autoimmunity
    • Journal Title

      Critical Reviews in Immunology

      Volume: 31(4) Pages: 265-95

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Role of miRNA in Rheumatoid Arthritis, Rheumatoid Arthritis - Etiology2011

    • Author(s)
      Kawano Sand Nakamachi Y. Andrew B. Lemmey (Ed.)
    • Journal Title

      Consequences and Co-Morbidities

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assembly defect due Q:1 to a PSMB8 mutation ; 2 reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome2011

    • Author(s)
      Arima K, Kinoshita A, Mishima H,Kanazawa N, Kaneko T, Mizushima T, Ichinose K, Nakamura H, Tsujino A,Kawakami A, Matsunaka M, Kasagi S, Kawano S, Kumagai S, Ohmura K, MimoriT, Hirano M, Ueno S, Tanaka K, Tanaka M, Toyoshima I, Sugino H, Yamakawa A,Tanaka K, Niikawa N, Furukawa F, Murata S, Eguchi K, Ida H, and Yoshiura K.
    • Journal Title

      PNAS U S A

      Volume: 108(36) Pages: 14914-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] miR-124a as a key regulator of proliferation and MCP-1 secretion in synoviocytes from patients with rheumatoid arthritis2011

    • Author(s)
      Kawano Sand Nakamachi Y
    • Journal Title

      Ann Rheum Dis

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of imaging studies in the diagnosis and evaluation of giant cell arteritis in Japanese: report of eight cases2011

    • Author(s)
      Morinobu A, Tsuji G, Kasagi S, Saegusa J, Hayashi H, Nakazawa T, Kogata Y, Misaki K, Nishimura K, Sendo S, Miura N, Kawano S,and Kumagai S.
    • Journal Title

      Mod Rheumatol

      Volume: 21(4) Pages: 391-6

    • NAID

      10029512930

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma platelet derived microparticles in patients with connective tissue diseases2011

    • Author(s)
      Ohyabu C, Morinobu A, Sugiyama D, Saegusa J, Tanaka S, Morinobu S, Tsuji G, Kasagi S, Kawano S, and Kumagai S
    • Journal Title

      J Rheumatol

      Volume: 38(4) Pages: 680-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production2011

    • Author(s)
      Siti Nur A Jauhaxoh, et al
    • Journal Title

      Biochem Biophys Res Comm

      Volume: 417 Issue: 1 Pages: 582-587

    • DOI

      10.1016/j.bbrc.2011.12.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PD-1 and Autoimmunity. Review. 2011;31(4) : 265-952011

    • Author(s)
      Kasagi S, et al
    • Journal Title

      Critical Reviews in Immunology

      Volume: 31 Pages: 265-295

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assembly defect due Q:1 to a PSMB8 mutation ; 2 reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome2011

    • Author(s)
      Arima K, et al
    • Journal Title

      PNAS U S A

      Volume: 108 Pages: 14914-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-124a as a key regulator of proliferation and MCP-1 secretion in synoviocytes from patients with rheumatoid arthritis.2011

    • Author(s)
      Kawano S, Nakamachi Y.
    • Journal Title

      Ann Rheum Dis.

      Volume: 70

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum matrix metalloproteinase-3 as predictor of joint destruction in rheumatoid arthritis, treated with non-biological disease modifying anti-rheumatic drugs2010

    • Author(s)
      Mamehara A, Sugimoto T, Sugiyama D, Morinobu S, Tsuji G, Kawano S,Morinobu A, and Kumagai S
    • Journal Title

      Kobe J Med Sci

      Volume: 56(3)

    • NAID

      110007670783

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prospective short-term effects of glucocorticoid treatment on glucose and lipid metabolism in Japanese2010

    • Author(s)
      Kuroki Y, Kaji H, Kawano S, Kanda F, Takai Y, Kajikawa M, and Sugimoto T
    • Journal Title

      Intern Med

      Volume: 49(10) Pages: 897-902

    • NAID

      130000251559

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-PD-1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice12010

    • Author(s)
      Kasagi S,Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, Shimatani K, Tanaka Y, Minato N, and Kumagai S
    • Journal Title

      J Immunol

      Volume: 84(5) Pages: 2337-47

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] マイクロ RNA 調節からみた関節リウマチ病態の理解2010

    • Author(s)
      河野 誠司
    • Journal Title

      自己抗体と自己免疫

      Volume: 10 Pages: 29-34

    • Related Report
      2012 Final Research Report
  • [Journal Article] 関節リウマチにおける microRNA の意義と役割2010

    • Author(s)
      河野 誠司, 中町 祐司, 熊谷 俊一.
    • Journal Title

      リウマチ科.

      Volume: 44 Pages: 105-11

    • Related Report
      2012 Final Research Report
  • [Journal Article] The HPB-AML-I cell line possesses the properties of mesenchymal stem cells.2010

    • Author(s)
      Ardianto B, et al.
    • Journal Title

      J Exp Clin Cancer Res.

      Volume: 29 Pages: 163-171

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dic(17;20) (p11;q11)preceded MLL gene amplification in a patient with de novo mixed-lineage leukemia.2010

    • Author(s)
      Amakawa R, et al.
    • Journal Title

      J Clin Exp Hematop.

      Volume: 50 Pages: 51-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 自己免疫疾患の診断の進歩 マイクロ RNA と自己免疫疾患.2011

    • Author(s)
      河野 誠司, 中町 祐司, 熊谷 俊一
    • Organizer
      第58回日本臨床検査医学会総会.
    • Place of Presentation
      岡山市、岡山コンベンションセンター
    • Year and Date
      2011-11-19
    • Related Report
      2012 Final Research Report
  • [Presentation] miR-124 as a key regulator of proliferation and MCP1 secretion in synoviocytes from RA patients.2010

    • Author(s)
      Kawano S.
    • Organizer
      The 12th Congress of Advances in Target Therapies
    • Place of Presentation
      Pullman Cannes Mandelieu Royal Casino Ex Sofitel, Mandelieu, France
    • Year and Date
      2010-04-16
    • Related Report
      2012 Final Research Report
  • [Presentation] MiR-124a as a key regulator of proliferation andMCP1 secretion in synoviocytes from RA patients.2010

    • Author(s)
      河野誠司
    • Organizer
      12nd MEETING OF ADCANCES IN TARGETED THERAPIES
    • Place of Presentation
      マンデリューホテル(フランス・マンデリュー)(招待講演)
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] MICRO RNA ASSOCIATED WITH RHEUMATOID ARTHRITIS2012

    • Inventor(s)
      seiji Kawano, yuji nakamachi
    • Industrial Property Rights Holder
      Kobe university
    • Acquisition Date
      2012-12-04
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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