| Project/Area Number |
22591081
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
YOSHIO Taku 自治医科大学, 医学部, 教授 (20221666)
|
|---|
| Research Collaborator |
KURASAWA Kazuhiro 独協医科大学, 医学部, 教授 (30282479)
DEI Yoshiaki 済生会宇都宮病院, 医長
OKAMOTO Hiroshi 南大塚クリニック, 院長 (10260100)
HIROHATA Shunsei 北里大学, 医学部, 教授 (90189895)
MINOTA Seiji 自治医科大学, 医学部, 教授 (30211593)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 全身性エリテマトーデス / 中枢神経ループス / ループス精神病 / 髄液 / サイトカイン / ケモカイン / 血液脳関門 / インターロイキン6 / 抗NMDAR2抗体 / 抗dsDNA抗体 / 血管内皮細胞 / 自己抗体 |
|---|
| Research Abstract |
1. Prospective study of the prevalence of NPSLE manifestation among patients with SLE in Tochigi from 2010 to 2012: 719 SLE patients were enrolled at the first of studyand 823 enrolled patients were confirmed at the end of study. Prevalence of SLE patient
2. The intrathecal production of IL-6, IL-8, IP-10, MCP-1 and G-CSF increase more highly than the serum production in patients with NPSLE: 52 SLE patients, of whom the CSF and serum samples were obtained at the same time, were enrolled. Of 52 SLE patients
|
