Prospective study of the prevalence of neuropsychiatric lupus erythematosus (NPSLE) manifestation among patients with SLE in Tochigi prefecture from 2010 to 2012 and the intrathecal production of IL-6, IL-8, IP-10, MCP-1 and G-CSF increase more highly tha
| Project/Area Number |
22591081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Jichi Medical University |
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Principal Investigator |
YOSHIO Taku 自治医科大学, 医学部, 教授 (20221666)
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| Research Collaborator |
KURASAWA Kazuhiro 独協医科大学, 医学部, 教授 (30282479)
DEI Yoshiaki 済生会宇都宮病院, 医長
OKAMOTO Hiroshi 南大塚クリニック, 院長 (10260100)
HIROHATA Shunsei 北里大学, 医学部, 教授 (90189895)
MINOTA Seiji 自治医科大学, 医学部, 教授 (30211593)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 全身性エリテマトーデス / 中枢神経ループス / ループス精神病 / 髄液 / サイトカイン / ケモカイン / 血液脳関門 / インターロイキン6 / 抗NMDAR2抗体 / 抗dsDNA抗体 / 血管内皮細胞 / 自己抗体 |
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| Research Abstract |
1. Prospective study of the prevalence of NPSLE manifestation among patients with SLE in Tochigi from 2010 to 2012: 719 SLE patients were enrolled at the first of studyand 823 enrolled patients were confirmed at the end of study. Prevalence of SLE patient
2. The intrathecal production of IL-6, IL-8, IP-10, MCP-1 and G-CSF increase more highly than the serum production in patients with NPSLE: 52 SLE patients, of whom the CSF and serum samples were obtained at the same time, were enrolled. Of 52 SLE patients
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Report
(4 results)
Research Products
(10 results)
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[Presentation] The intrathecal production of IL-6, IL-8, IP-10, MCP-1 and G-CSFincrease more highly than the serum production in patients with central neuropsychiatric lupus erythematosus (NPSLE).2011
Author(s)
Taku Yoshio, Hiroshi Okamoto, Kazuhiro Kurasawa, Yoshiaki Dei, Shunsei Hirohata, Seiji Minota.
Organizer
American College of Rheumatology 75th Annual Scientific Meeting 2011
Place of Presentation
Chicago, Illinois, USA
Year and Date
2011-11-07
Related Report
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