Activation of ER stress as the major molecular pathology in autism spectrum disorder and the animal model for intervention study
| Project/Area Number |
22591135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
MOMOI Mariko 自治医科大学, 医学部, 教授 (90166348)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masato 自治医科大学, 医学部, 講師 (10337347)
SAITO Mari 自治医科大学, 医学部, 研究員 (10424011)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 内科系臨床医学 / 小児科学 / 自閉性障害 / CADM1 / 自閉性障害関連遺伝子 / ERストレス |
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| Research Abstract |
We reported that the loss of Cadm1, one of the autism-related gene, caused decreased social ability, anxiety and aggression. The cells expressed mutated CADM1 protein showed the aberrant and aborted extension of neuronal spikes and the decreased synaptogenesis. We also detected that the mutated CADM1 expressing cells showed the activation of CHOP and beclin, that suggest the activation of ER stress in the cells.
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Report
(3 results)
Research Products
(7 results)
