The role of microglia under the mechanisms of neuronal damage after seizure in the hippocampus
| Project/Area Number |
22591139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Chisen 東京女子医科大学, 医学部, 非常勤講師 (70333094)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 小児神経学 / IL-1beta / 神経細胞傷害 / mPGES-1 / EP3 / 神経細胞 / アストロサイト / 組織培養 / カイニン酸 / 血管内皮細胞 / インターロイキン1β / インターロイキン1レセプター1 / 誘導型PGE2合成酵素mPGES-1 / EPレセプター |
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| Research Abstract |
I found that Interleukin-1β（IL-1β）produced in microglia stimulated an induction of mPGES-1 in endothelial cells and EP3 receptor on astrocyte under the intercellular mechanisms of neuronal injury after seizure. In addition, IL-1β affected on IL-1Receptor Type1 (IL-1R1) on the astrocyte to increase EP3 induction. On the other hand, IL-1β might regulate constructing a basic structure, suggesting a necessity to investigate the role of IL-1β in detail
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Report
(4 results)
Research Products
(22 results)
