| Project/Area Number |
22591201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
KUSAKA Takashi 香川大学, 医学部附属病院, 講師 (50274288)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Masaki 香川大学, 医学部, 準教授 (30322267)
MIKI Takanori 香川大学, 医学部, 準教授 (30274294)
YASUDA Saneyuki 香川大学, 医学部附属病院, 助教 (00380155)
IWASE Takashi 香川大学, 医学部附属病院, 助教 (30284368)
NISHIDA Tomoko 香川大学, 教育学部, 教授 (00243759)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 低酸素性虚血性脳症 / 脳波 / 脳血液量 / 動物モデル / 虚血再還流 / 新生仔豚 / 低酸素虚血負荷 / 近赤外光 / 新生児 / 新生児仮死 / 活性酸素スカベンジャー |
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| Research Abstract |
In these studies, we found that combining the cerebral blood volume (CBV) with amplitude-integrated EEG (aEEG) is a more effective guide to control hypoxic/ischemic (HI) insult in a newborn piglet model than aEEG alone, to produce a consistent degree of survivable neuropathological damage. Next, we found that an early CBV increase and longer low-ampitude EEG after insult indicates severe brain injury. Finally, we revealed that Edaravone (a free radical scavenger) reduced histologic neuronal damage related to HI loading in our piglet HI model.
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