Creation of atopic dermatitis model mouse using double knock out mouse
| Project/Area Number |
22591240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kagawa University |
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Principal Investigator |
YONEDA Kozo 香川大学, 医学部附属病院, 准教授 (60260626)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Yasuo 香川大学, 医学部, 教授 (10126047)
ARAKI Nobukazu 香川大学, 医学部, 教授 (10202748)
NAKAI Kozo 香川大学, 医学部, 助教 (40363204)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | ロリクリン / ノックアウトマウス / 魚鱗癬 / アトピー性皮膚炎 / バリア / フレーキーテールマウス / フィラグリン |
|---|
| Research Abstract |
Atopic dermatitis is one of intractable skin diseases. The clinical feature of this disease is itchy eczema. This disease is caused by mutations in filaggrin gene now. Loricrin is major constituent of marginal band of epidermal corneocyte. The clinical aspects of the variant form of Vohwinkel syndrome are mutilating keratoderma with ichthyosis. This phenotype is similar to ichthyosis vulgaris. Ichthyosis vulgaris is caused by homozygous or compound heterozygous mutations in the filaggrin gene. The aim of this project is creation of atopic dermatitis mouse model using loricrin knock out mouse.
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Report
(5 results)
Research Products
(53 results)
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[Journal Article] A founder effect of c.1938delC in ITGB4 underlies junctional epidermolysis bullosa and its application for prenatal testing2011
Author(s)
Natsuga K, Nishie W, Shinkuma S, Nakamura H, Arita K, Yoneda K, Kusaka T, Yanagihara T, Kosaki R, Sago H, Akiyama M and Shimizu H
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Journal Title
Exp Dermatol
Volume: 20
Pages: 74-76
Related Report
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[Journal Article] Bevacizumab-induced hand-foot syndrome: circumscribed type2010
Author(s)
Munehiro A, Yoneda K, Nakai K, Demitsu T, Moriue T, Moriue J, Yokoi I, Fujita N, Matsuura N, Ishikawa S, Yokomise H and Kubota Y
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Journal Title
Br J Dermatol
Volume: 162
Pages: 1411-1413
Related Report
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[Journal Article] Expression of wild-type, but not mutant, loricrin causes programmed cell death in HaCaT keratinocytes2010
Author(s)
Yoneda K, Demitsu T, Manabe M, Igarashi J, Kosaka H, Inagaki N, Takahashi H, Kon A, Kakurai M and Kubota Y
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Journal Title
J Dermatol
Volume: 37
Pages: 956-964
NAID
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