Intracellular parasitization of Mycobacterium leprae and development of leprosy
Project/Area Number |
22591253
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
ISHII Norihisa 国立感染症研究所, ハンセン病研究センター, センター長 (50159670)
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Co-Investigator(Kenkyū-buntansha) |
SUZUKI Koichi 国立感染症研究所, ハンセン病研究センター感染制御部, 室長 (20206478)
MORI Syuichi 国立感染症研究所, ハンセン病研究センター感染制御部, 室長 (40559522)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ハンセン病 / らい菌 / 細胞内寄生 / 感染症 / 細菌 |
Research Abstract |
Upon infection, Mycobacterium leprae (M. leprae), a causative agent of leprosy, modulates expression and localization of host proteins necessary for inhibition of phagosome-lysosome fusion, and for lipid accumulation or catabolism to create cellular microenvironment that is favorable for its intracellular parasitization. Only live M. leprae, but not heat-killed M. leprae had such effects. One of the drugs used to treat leprosy, clofazimine, suppressed such effects of M. leprae.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article]2012
Author(s)
犀川一夫、森修一、石井則久
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Journal Title
世界ハンセン病疫病史-ヨーロッパを中心として- (皓星社)
Pages: 1-357
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[Journal Article] らい菌2010
Author(s)
石井則久、森修一、朝比奈昭彦
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Journal Title
広範囲血液・尿化学検査免疫学的検査―その数値をどう読むか―
Volume: 第7 版(3)
Pages: 165-167
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[Journal Article] Detection of Mycobacterium leprae DNA from archaeological skeletal remains in Japan using whole genome amplification and polymerase chain reaction.2010
Author(s)
Suzuki K, Takigawa W, Tanigawa K, Nakamura K, Ishido Y, Kawashima A, Wu H, Akama T, Sue M, Yoshihara A, Mori S, Ishii N
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Journal Title
PLoS ONE
Volume: 5
Issue: 8
Pages: e12422-e12422
DOI
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[Journal Article] Detection of Mycobacterium leprae DNA from archaeological skeletal remains in Japan using whole genome amplification and polymerase chain reaction2010
Author(s)
Suzuki K, Takigawa W, Tanigawa K, Nakamura K, Ishido Y, Kawashima A, Wu H, Akama T, Sue M, Yoshihara A, Mori S, Ishii N
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Peer Reviewed
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[Book] Whole genome tiling array analysis of bacterial genome. Chapter7 (Campbell MJ (Eds): DNA Microarrays, Synthesis and Synthetic DNA.)2011
Author(s)
Akama T, Tanigawa K, Nakamura K, Kawashima A, Wu H, Sue M, Yoshihara A, Ishido Y, Ishii N, Suzuki K
Publisher
Nova Science Publishers, Hauppauge
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