Anti-suicidal effects of lithium in drinking water after adjustment of several factors potentially affecting suicide

• Project/Area Number: 22591264
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Oita University
• Principal Investigator: ISHII Nobuyoshi 大分大学, 医学部, 助教 (00555063)
• Co-Investigator(Kenkyū-buntansha): TERAO Takeshi 大分大学, 医学部, 教授 (80217413)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 自殺 / リチウム / 水道水 / 人間生活環境 / 水資源 / 抗自殺効果

Research Abstract

We investigated anti-suicidal effects of lithium in an epidemiological setting. Lithium levels of drinking water were measured at 297 points in 118 cities and their associations with suicide rates were calculated after adjustment of several factors potentially affecting suicides. As a result, lithium levels were significantly and negatively associated with female suicide rates in Oita, Saga, and Nagasaki prefectures.

Research Products

• [Journal Article] Risk factors for suicide in Japan: A model of predicting suicide in 2008 by risk factors of 2007 (2013)
  • Author(s): Ishii N, Terao T, Araki Y, Kohno K, Mizokami Y, Arasaki M, Iwata N
  • Journal Title: J Affect Disord Volume: 147(1-3) Issue: 1-3 Pages: 352-354
  • DOI: 10.1016/j.jad.2012.11.038
  • Peer Reviewed
• [Journal Article] 自殺予防と lithium (2012)
  • Author(s): 寺尾 岳、 石井 啓義
  • Journal Title: 臨床精神薬理 Volume: 15 Pages: 1491-1496
• [Journal Article] 自殺予防とlithium (2012)
  • Author(s): 寺尾 岳、石井 啓義
  • Journal Title: 臨床精神薬理 Volume: 15 Pages: 1491-1496
• [Journal Article] Low-dose lithium uptake promotes longevity in humans and metazoans (2011)
  • Author(s): Zarse K, Terao T, Tian J, Iwata N, Ishii N, Ristow M
  • Journal Title: Eur J Nutr.Epub Volume: 50(5) Issue: 5 Pages: 387-9
  • DOI: 10.1007/s00394-011-0171-x
  • Peer Reviewed
• [Journal Article] ムードスタビライザーとしてのlithiumの現状と課題 (2011)
  • Author(s): 寺尾岳
  • Journal Title: 臨床精神薬理 Volume: 14 Pages: 1463-1469
  • Peer Reviewed
• [Journal Article] 気分安定薬の自殺予防効果 (2011)
  • Author(s): 寺尾岳、石井啓義
  • Journal Title: 臨床精神薬理 Volume: 14 Pages: 1967-1972
  • Peer Reviewed
• [Journal Article] Low-dose lithium uptake promotes longevity in humans and metazoans (2011)
  • Author(s): Zarse Kim, Takeshi Terao, Tian Jing, Noboru Iwata, Nobuyoshi Ishii, Michael Ristow
  • Journal Title: European Journal of Nutrition Volume: (in press)
  • Peer Reviewed
• [Presentation] 水道水中のリチウムは自殺予防に働くか? (2011)
  • Author(s): 石井啓義、寺尾 岳、河野健太郎、荒木康夫、溝上義則
  • Organizer: 第107回日本精神神経学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-26
• [Presentation] 水道水中のリチウムは自殺予防に働くか? (2011)
  • Author(s): 石井啓義、寺尾岳、河野健太郎、荒木康夫、溝上義則
  • Organizer: 第107回日本精神神経学会学術総会
  • Place of Presentation: 東京「ホテルパシフィックLEDAIBA、ホテル日航東京」
  • Year and Date: 2011-10-26
• [Presentation] メンタルヘルスにおける温泉入浴と冷泉飲泉の比較:これまでの研究の総括 (2011)
  • Author(s): 石井啓義、寺尾 岳
  • Organizer: 平成 23 年度大分県温泉調査研究会通常総会及び研究発表会
  • Place of Presentation: 大分
  • Year and Date: 2011-08-02