Molecular imaging study on dopaminergic system in autism: in relation to deficits in memory reconstruction
| Project/Area Number |
22591280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKAGAI Shu 浜松医科大学, 子どものこころの発達研究センター, 准教授 (10447807)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kazuhiko 弘前大学, 医学系研究科, 教授 (80263911)
SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040)
IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025)
OUSHI Yasuomi 浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978)
TAKEBAYASHI Kiyokazu 浜松医科大学, 医学部附属病院, 講師 (50397428)
MORI Norio 浜松医科大学, 医学部, 教授 (00174376)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 児童 / 思春期精神医学 / 分子イメージング / ドパミン系 / PET / 自閉症 / 児童・思春期精神医学 / 記憶障害 |
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| Research Abstract |
Using positron emission tomography (PET), we measured the binding of brain dopamine D1 receptors in fifteen men with high-functioning autism and 15 age- and IQ-matched control subjects with the radioligand [11C]SCH23390. Statistical parametric mapping was used for between-subject analysis and within-subject correlation analysis withrespect to clinical variables.Analyses are still ongoing.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Microglial activation in young adults with autism spectrum disorder2013
Author(s)
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y, Tsujii M, Sugiyama T, Mori N
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Journal Title
JAMA Psychiatry
Volume: 70
Pages: 49-58
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