• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of Novel PET Probes for Metabotropic Glutamate Receptor Subtype 1 (mGluR1)

Research Project

Project/Area Number 22591379
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

MING-RONG Zhang  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, プログラムリーダー (80443076)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords放射性医薬品 / 造影剤PETイメージング剤 / PET / 分子イメージング / 核医学 / mGluR1 / 脳疾患
Research Abstract

Metabotropic glutamate receptor subtype (mGluR1) has many important roles on ischemic, pain and epilepsy, etc. In this study, we have developed novel PET probes for imaging of mGlu1 in brain, with potential for imaging the mGlu1 receptor in rodent and primate brains. Of these new candidates, [11C]ITMM is being used clinically for the study of human brain to elucidate the distribution and density of mGlu1 receptor.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (9 results) Remarks (2 results)

  • [Journal Article] Preclinical and the first clinical studies on [11C]ITMM for mapping metabotropic glutamate receptor type 1 by positron emission tomography2013

    • Author(s)
      Toyohara J.,Zhang M.-R.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 40 Issue: 2 Pages: 214-220

    • DOI

      10.1016/j.nucmedbio.2012.11.008

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamide for positron emission tomography imaging of metabotropic glutamate 1 receptor in monkey brain.2012

    • Author(s)
      Masayuki Fujinaga
    • Journal Title

      J Med Chem

      Volume: 55 Issue: 24 Pages: 10042-10051

    • DOI

      10.1021/jm301597s

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo measurement of the affinity and density of metabotropic glutamate receptor subtype 1 (mGluR1) in rat brain using [18F]FITM in small-animal PET2012

    • Author(s)
      Yamasaki T,Zhang M.-R
    • Journal Title

      Journal of Nuclear Medicine

      Volume: 53 Issue: 10 Pages: 1601-1607

    • DOI

      10.2967/jnumed.112.105908

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of 1-(2-[18F] fluoro-3-pyridyl)-4-(2-isopropyl-1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains2012

    • Author(s)
      Fujinaga M, Maeda J, Yui J, Hatori A, Yamasaki T, Kawamura K, Kumata K, Yoshida Y, Nagai Y, Higuchi M, Suhara T, Fukumura T, Zhang MR
    • Journal Title

      J Neurochem

      Volume: 121(1) Issue: 1 Pages: 115-24

    • DOI

      10.1111/j.1471-4159.2011.07348.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of novel radioligands for positron emission tomography imaging metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain2012

    • Author(s)
      Fujinaga M, Zhang M.-R
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 55 Issue: 5 Pages: 2342-2352

    • DOI

      10.1021/jm201590g

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM2012

    • Author(s)
      Yamasaki T, Fujinaga M, Maeda J, Kawamura K, Yui J, Hatori A, Yoshida Y, Nagai Y, Tokunaga M, Higuchi M, Suhara T, Fukumura T, Zhang MR
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 39(4) Issue: 4 Pages: 632-641

    • DOI

      10.1007/s00259-011-1995-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging for metabotropic glutamate receptor subtype1 in rat and monkey brains using PET with [^<18>F]FITM2012

    • Author(s)
      Ming-Rong Zhang, et al
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 39 Pages: 632-641

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ^<18>F-FPIT : A PET Ligand for Imaging of the Metabotropic Glutamate Receptor Type 1 in Rodent and Primate Brains2012

    • Author(s)
      Ming-Rong Zhang, et al
    • Journal Title

      Journal of Neurochemistry

      Volume: 121 Pages: 115-124

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiosynthesis and preliminary evaluation of 4-[18F]fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 12011

    • Author(s)
      Yamasaki T, Zhang M.-R
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 21 Issue: 10 Pages: 2998-3001

    • DOI

      10.1016/j.bmcl.2011.03.046

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of 6-[1-(2-[18F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain2011

    • Author(s)
      Fujinaga M, Zhang MR
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 19 Issue: 1 Pages: 102-110

    • DOI

      10.1016/j.bmc.2010.11.048

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of 6-[1-(2-[^<18>F]fluoro-3-pyridyl)-5-methyl-lH-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 inbrain2011

    • Author(s)
      Ming-Rong Zhang, et al.
    • Journal Title

      Bioorganic & Medicinal Chemistry.

      Volume: 19 Pages: 102-110

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiosynthesis and evaluation of [^<11>C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 12010

    • Author(s)
      Ming-Rong Zhang, et al.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 37 Pages: 615-624

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 代謝調節型グルタメート受容体サブタイプ1型のPETイメージング剤の開発と応用2012

    • Author(s)
      張 明栄
    • Organizer
      IBICセミナー
    • Place of Presentation
      国立精神医療センター
    • Year and Date
      2012-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of Radiolabeling Technique for PET Probe2011

    • Author(s)
      張 明栄
    • Organizer
      ワークショップ&放医研-北大教育プログラムに本ワークショップ
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 短寿命放射性合成中間体の製造とPETプローブ開発への応用2011

    • Author(s)
      張 明栄
    • Organizer
      第4回岡山大&理研ジョイントシンポジウム -先端計測技術と分析化学イノベーション
    • Place of Presentation
      岡山大学
    • Year and Date
      2011-07-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Recent advance in development of positron emission tomography probes for brain and tumor imaging2011

    • Author(s)
      Ming-Rong Zhang
    • Organizer
      2011' National Forum of Tumor Marker and Molecular Targeted Diagnosis & Treatment by Nuclear medicine
    • Place of Presentation
      中国、南京
    • Year and Date
      2011-05-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of Two PET probes [18F]FPTQ and [18F]FPIT for imaging of metabotropic glutamate receptor 1 (mGluR1)in brain2011

    • Author(s)
      張 明栄
    • Organizer
      中国腫瘍及び核医学分子標的診断シンポジウム
    • Place of Presentation
      南京医科大学、中国
    • Year and Date
      2011-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of PET probes for metabotropic glutamate recepfor type 1 in brain2010

    • Author(s)
      Ming-Rong Zhang
    • Organizer
      Seminar of Nanjing Medicinal University
    • Place of Presentation
      Nanjing, China
    • Year and Date
      2010-10-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development and production of radiopharmaceuticals in National Institute of Radiological Sciences (NIRS)2010

    • Author(s)
      張 明栄
    • Organizer
      Eighth China-Japan Joint Seminar on Radiopharmaceutical Chemistry
    • Place of Presentation
      北京師範大学、中国
    • Year and Date
      2010-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Development and production of radiopharmaceuticals in National Institute of Radiological Sciences (NIRS)2010

    • Author(s)
      Ming-Rong Zhang
    • Organizer
      Eighth China-Japan joint seminar on radiop harmaceutical Chemistry
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] New ^18F-Radiochemistry and Application for Development of PET Imaging Agents、2nd Research Coordination Meeting on Development of ^18F-labelled Radiopharmaceuticals (beyond [^18F]FDG) for Use in Oncology and Neurosciences2010

    • Author(s)
      張 明栄
    • Organizer
      国際原子力機構
    • Place of Presentation
      ウイーン、オーストリア
    • Year and Date
      2010-10-04
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.nirs.go.jp/research/division/mic/group/t_hyoshiki-gijutu.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nirs.go.jp/research/division/mic/group/t_hyoshiki-gijutu.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi