Development of Novel PET Probes for Metabotropic Glutamate Receptor Subtype 1 (mGluR1)
| Project/Area Number |
22591379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
MING-RONG Zhang 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, プログラムリーダー (80443076)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 放射性医薬品 / 造影剤PETイメージング剤 / PET / 分子イメージング / 核医学 / mGluR1 / 脳疾患 |
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| Research Abstract |
Metabotropic glutamate receptor subtype (mGluR1) has many important roles on ischemic, pain and epilepsy, etc. In this study, we have developed novel PET probes for imaging of mGlu1 in brain, with potential for imaging the mGlu1 receptor in rodent and primate brains. Of these new candidates, [11C]ITMM is being used clinically for the study of human brain to elucidate the distribution and density of mGlu1 receptor.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Characterization of 1-(2-[18F] fluoro-3-pyridyl)-4-(2-isopropyl-1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains2012
Author(s)
Fujinaga M, Maeda J, Yui J, Hatori A, Yamasaki T, Kawamura K, Kumata K, Yoshida Y, Nagai Y, Higuchi M, Suhara T, Fukumura T, Zhang MR
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Journal Title
J Neurochem
Volume: 121(1)
Issue: 1
Pages: 115-24
DOI
Related Report
Peer Reviewed
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[Journal Article] Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM2012
Author(s)
Yamasaki T, Fujinaga M, Maeda J, Kawamura K, Yui J, Hatori A, Yoshida Y, Nagai Y, Tokunaga M, Higuchi M, Suhara T, Fukumura T, Zhang MR
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 39(4)
Issue: 4
Pages: 632-641
DOI
Related Report
Peer Reviewed
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