| Project/Area Number |
22591446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
ITO Yuko 大阪医科大学, 医学部, 講師 (40148432)
|
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKI Yoshinori 大阪医科大学, 医学部, 教授 (50140166)
SHIBATA Masa-aki 大阪保健医療大学, 保健医療部, 教授 (10319543)
MORIMOTO Junji 大阪医科大学, 医学部, 講師 (90145889)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
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| Keywords | 乳癌 / リンパ管新生 / 血管新生 / CEACAM-1 / Microvesicles / 癌治療 / リンパ行性転移 / マウス乳癌 / リンパ管リプログラミング / 遺伝子導入 / Prox-1 / VEGFR-3 / LYVE-1 / VEGF-C / Podolanin / リン酸化VEGFR-3 |
|---|
| Research Abstract |
In a highly metastatic mouse mammary carcinoma model which express VEGF-C strongly, CEACAM-1 promots angiogenesis and lymphangiogenesis. I t was suggested that the blood capillaries which expressed CEACAM-1 on the endothelium were remodeled into lymphatic capillaries. Moreover, shedding vesicles containing CEACAM-1 were released from mouse mammary carcinoma cells and may be engulfed byendothelial cells of blood capillaries.
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