Breakthrough of mechanism in micrometastasis using micrometastatic model of esophageal cancer
Project/Area Number |
22591450
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Gunma University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YOKOBORI Takehiko 群馬大学, 医学系研究科, 助教 (60420098)
SAKAI Makoto 群馬大学, 医学部附属病院, 助教 (70420099)
SOHDA Makoto 群馬大学, 医学部附属病院, 助教 (70507326)
KUWANO Hiroyuki 群馬大学, 医学系研究科, 教授 (90186560)
田中 成岳 群馬大学, 医学部, 助教 (30546726)
猪瀬 崇徳 群馬大学, 医学部, 助教 (90609968)
|
Project Period (FY) |
2010-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 微小転移 / 腹膜播種 / 癌 / 食道癌 / 同所移植モデル / 同所移植転移モデル微小転移 / 同所移植転移モデル |
Outline of Final Research Achievements |
We have established mice model to evaluate peritoneal micro metastatic nest, because we could not establish orthotopic transplantation model. We used colon-26-luc cell line and 7-week-old female Balb-c mice. We could visualize micro peritoneal cancer nest as a light of luciferase. We also measured the weight of peritoneal tissue to quantify tumor volume, that related luminescence intensity. We establish the method to evaluate disease progression without sacrifice of mice.
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Report
(6 results)
Research Products
(26 results)
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[Journal Article] Phase II Study of Docetaxel, Nedaplatin, and 5-Fluorouracil Combined Chemotherapy for Advanced Esophageal Cancer.2015
Author(s)
Miyazaki T, Ojima H, Fukuchi M, Sakai M, Sohda M, Tanaka N, Suzuki S, Ieta K, Saito K, Sano A, Yokobori T, Inose T, Nakajima M, Kato H, Kuwano H.
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Journal Title
Ann Surg Oncol.
Volume: [Epub ahead of print]
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Phase I/II study of docetaxel, cisplatin, and 5-fluorouracil combination chemoradiotherapy in patients with advanced esophageal cancer.2015
Author(s)
Miyazaki T, Sohda M, Tanaka N, Suzuki S, Ieta K, Sakai M, Sano A, Yokobori T, Inose T, Nakajima M, Fukuchi M, Ojima H, Kato H, Kuwano H.
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Journal Title
Cancer Chemother Pharmacol.
Volume: 75
Issue: 3
Pages: 449-55
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Intestinal epithelial culture under an air-liquid interface: a tool for studying human and mouse esophagi.2015
Author(s)
Yokobori T, Suzuki S, Miyazaki T, Sohda M, Sakai M, Tanaka N, Ozawa D, Hara K, Honjo H, Altan B, Fukuchi M, Ishii H, Iwatsuki M, Sugimachi K, Sudo T, Iwaya T, Nishida N, Mimori K, Kuwano H, Mori M.
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Journal Title
Dis Esophagus.
Volume: [Epub ahead of print]
Issue: 7
Pages: 843-847
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] L-[3-18F]-α-methyltyrosine uptake by lymph node metastasis is a predictor of complete response to CRT in esophageal cancer.2014
Author(s)
Sohda M, Miyazaki T, Honjyo H, Hara K, Ozawa D, Suzuki S, Tanaka N, Sano A, Sakai M, Yokobori T, Nakajima M, Fukuchi M, Kato H, Higuchi T, Tsushima Y, Kuwano H.
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Journal Title
Anticancer Res.
Volume: 34
Pages: 7473-7
Related Report
Peer Reviewed
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[Journal Article] Salvage lymphadenectomy for recurrent esophageal cancer after chemoradiotherapy.2014
Author(s)
Nakajima M, Domeki Y, Satomura H, Takahashi M, Sugawara A, Muroi H, Sasaki K, Yamaguchi S, Miyazaki T, Kuwano H, Kato H.
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Journal Title
Int Surg.
Volume: 99
Issue: 4
Pages: 452-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Use of pre-treatment 18F-FAMT PET to predict patient survival in squamous cell carcinoma of the esophagus treated by curative surgery.2014
Author(s)
Sohda M, Sakai M, Honjyo H, Hara K, Ozawa D, Suzuki S, Tanaka N, Yokobori T, Miyazaki T, Fukuchi M, Higuchi T, Tsushima Y, Kuwano H.
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Journal Title
Anticancer Res.
Volume: 34
Pages: 3623-8
Related Report
Peer Reviewed
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[Journal Article] Biological significance of fluorine-18-α-methyltyrosine (FAMT) uptake on PET in patients with oesophageal cancer.2014
Author(s)
Suzuki S, Kaira K, Ohshima Y, Ishioka NS, Sohda M, Yokobori T, Miyazaki T, Oriuchi N, Tominaga H, Kanai Y, Tsukamoto N, Asao T, Tsushima Y, Higuchi T, Oyama T, Kuwano H.
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Journal Title
Br J Cancer
Volume: Epub ahead of print
Issue: 8
Pages: 1985-1991
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] L-[3-18F]-α-methyltyrosine accumulation as a definitive chemoradiotherapy response predictor in patients with esophageal cancer.2014
Author(s)
Sohda M, Honjyo H, Hara K, Ozawa D, Suzuki S, Tanaka N, Sano A, Sakai M, Yokobori T, Inose T, Miyazaki T, Ojima H, Higuchi T, Tsushima Y, Kuwano H.
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Journal Title
Anticancer Res
Volume: 34(2)
Pages: 909-13
Related Report
Peer Reviewed
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[Journal Article] Effectiveness of FDG-PET in screening of synchronous cancer of other organs in patients with esophageal cancer.2014
Author(s)
Miyazaki T, Sohda M, Higuchi T, Tanaka N, Suzuki S, Sakai M, Yokobori T, Nakajima M, Fukuchi M, Tsushima Y, Kato H, Kuwano H.
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Journal Title
Anticancer Res
Volume: 34(1)
Pages: 283-7
Related Report
Peer Reviewed
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[Journal Article] FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs.2014
Author(s)
Yokobori T, Yokoyama Y, Mogi A, Endoh H, Altan B, Kosaka T, Yamaki E, Yajima T, Tomizawa K, Azuma Y, Onozato R, Miyazaki T, Tanaka S, Kuwano H.
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Journal Title
Mol Cancer Res.
Volume: 12(1)
Issue: 1
Pages: 32-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of total colonoscopy for screening of colon lesions in patients with esophageal cancer.2013
Author(s)
Miyazaki T, Tanaka N, Sano A, Suzuki S, Sakai M, Yokobori T, Inose T, Sohda M, Nakajima M, Fukuchi M, Ojima H, Kato H, Kuwano H.
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Journal Title
Anticancer Res
Volume: 33(11)
Pages: 5113-7
Related Report
Peer Reviewed
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[Journal Article] Re-thoracotomy for intrathoracic complications after esophagectomy for esophageal cancer2013
Author(s)
Miyazaki T, Inose T, Tanaka N, Suzuki S, Hara K, Ozawa D, Yokobori T, Sakai M, Souda M, Fukuchi M, Kuwano H.
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Journal Title
Kyobu Geka
Volume: 66(8 Suppl)
Pages: 762-6
NAID
Related Report
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[Journal Article] Ghrelin Level and Body Weight Loss After Esophagectomy for Esophageal Cancer2011
Author(s)
Miyazaki T, Tanaka N, Hirai H, Yokobori T, Sano A, Sakai M, Inose T, Sohda M, Nakajima M, Fukuchi M, Kato H, Kuwano H
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Journal Title
J Surg Res.
Volume: (Epub ahead of print)
Issue: 1
Pages: 74-78
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of heat shock protein 110 expression and T lymphocyte infiltration in esophageal cancer2011
Author(s)
Nakajima M, Kato H, Miyazaki T, Fukuchi M, Masuda N, Fukai Y, Sohda M, Inose T, Sakai M, Sano A, Tanaka N, Ahmad F, Kuwano H
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Journal Title
Hepatogastroenterology
Volume: 58
Pages: 1555-1560
Related Report
Peer Reviewed
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