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Investigation of the mechanisms of pouchitis after IPAA for patients with ulcerative colitis.

Research Project

Project/Area Number 22591476
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

OGAWA Hitoshi  東北大学, 病院, 講師 (00312570)

Co-Investigator(Kenkyū-buntansha) SHIBATA Chikashi  東北大学, 大学院・医学系研究科, 准教授 (30270804)
SASAKI Iwao  東北大学, 大学院・医学系研究科, 教授 (60125557)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords潰瘍性大腸炎 / 回腸嚢炎 / 粘膜免疫機構 / 発症機序 / 潰瘍大腸炎
Research Abstract

In the clinical study, we evaluated the long-term outcome of pouchitis following total proctocolectomy and IPAA for patients with ulcerative colitis. In the basic study, we revealed the effect of IL-23 in the intestinal neuroendocrine and cancer cells.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (10 results)

  • [Journal Article] Adenocarcinoma associated with perianal fistulas in Crohn's disease2013

    • Author(s)
      Ogawa H, Haneda S, Shibata C, Miura K, Nagao M, Ohnuma S, Kohyama A, Unno M.
    • Journal Title

      Anticancer Res

      Volume: 33(2) Pages: 685-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adenocarcinoma associated with perianal fistulas in Crohn's disease2013

    • Author(s)
      Ogawa H
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 685-689

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A shift from colon- to ileum-predominant bacteria in ileal-pouch feces following total proctocolectomy2012

    • Author(s)
      Hinata M, Kohyama A, Ogawa H, Haneda S, Watanabe K, Suzuki H, Shibata C, Funayama Y, Takahashi K, Sasaki I, Fukushima K.
    • Journal Title

      Dig Dis Sci

      Volume: 57(11) Issue: 11 Pages: 2965-74

    • DOI

      10.1007/s10620-012-2165-9

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A unique variant of afferent limb syndrome after ileal pouch-anal anastomosis: a case series and review of the literature2012

    • Author(s)
      Ogawa H, Haneda S, Watanabe K, Suzuki H, Miura K, Ohnuma S, Sasaki H, Shibata C, Unno M
    • Journal Title

      J Gastrointest Surg

      Volume: 16(8) Issue: 8 Pages: 1581-4

    • DOI

      10.1007/s11605-012-1872-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma2012

    • Author(s)
      Suzuki H, Ogawa H, Miura K, Haneda S, Watanabe K, Ohnuma S, Sasaki H, Sase T, Kimura S, Kajiwara T, Komura T, Toshima M, Matsuda Y, Shibata C, Sasaki I
    • Journal Title

      Oncol Lett

      Volume: 4(2) Pages: 199-204

    • Related Report
      2012 Final Research Report
  • [Journal Article] The long-term clinical course of pouchitis after total proctocolectomy and IPAA for ulcerative colitis2012

    • Author(s)
      Suzuki H, Ogawa H, Shibata C, Haneda S, Watanabe K, Takahashi K, Funayama Y, Sasaki I.
    • Journal Title

      Dis Colon Rectum

      Volume: 55(3) Issue: 3 Pages: 330-6

    • DOI

      10.1097/dcr.0b013e3182417358

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma2012

    • Author(s)
      Suzuki H
    • Journal Title

      Oncol Lett

      Volume: 4 Pages: 199-204

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A unique variant of afferent limb syndrome after ileal pouch-anal anastomosis: a case series and review of the literature2012

    • Author(s)
      Ogawa H
    • Journal Title

      J Gastrointest Surg

      Volume: 16 Pages: 1581-1584

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【潰瘍性大腸炎-長期経過観察例の諸問題】術後長期経過例の推移2011

    • Author(s)
      渡辺和宏、小川仁、柴田近, 他
    • Journal Title

      臨床消化器内科

      Volume: 26(8) Pages: 1145-1151

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 難治性潰瘍性大腸炎-診療・治療の新たな展開】主題難治性回腸嚢炎の病態と治療2011

    • Author(s)
      福島浩平、小川仁、柴田近, 他
    • Journal Title

      胃と腸

      Volume: 46(3) Pages: 2003-2008

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 回腸嚢炎の診断と分類2010

    • Author(s)
      小川仁
    • Journal Title

      IBD Research

      Volume: 4 Pages: 75-80

    • Related Report
      2010 Annual Research Report
  • [Journal Article] C.Difficile関連難治性回腸嚢炎の3例2010

    • Author(s)
      小川仁, ほか
    • Journal Title

      日本消化器外科学会雑誌

      Volume: 43 Pages: 270-276

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大腸全摘・回腸嚢肛門吻合術後Afferent Loop Syndromeの検討2012

    • Author(s)
      小川仁、柴田近、三浦康、佐々木宏之、羽根田祥、渡辺和宏、鈴木秀幸、海野倫明
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-23 Regulates Gene Expressions via STAT3 Activation in the Human Intestinal Neuroendocrine Cell Line2012

    • Author(s)
      Suzuki H, Ogawa H, Miura K, Naitoh T, Shibata C
    • Organizer
      DDW2012
    • Place of Presentation
      アメリカ合衆国(San Diego)
    • Year and Date
      2012-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-23はSTAT3を介して腸管の神経内分泌細胞に作用する2012

    • Author(s)
      鈴木秀幸、小川仁,三浦康,内藤剛,羽根田祥,渡辺和宏,大沼忍,佐々木宏之,鹿郷昌之,田中直樹,工藤克昌,佐瀬友彦,木村俊一,梶原大輝,小村俊博,戸嶋政秀,松田泰史,柴田近,佐々木巌
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-21
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-23は直接的に大腸癌の増殖能・浸潤能を亢進させる2012

    • Author(s)
      鈴木秀幸、小川仁,三浦康,羽根田祥,渡辺和宏,大沼忍,佐々木宏之,佐瀬友彦,木村俊一,梶原大輝,小村俊博,戸嶋政秀,松田泰史,柴田近,佐々木巖
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 潰瘍性大腸炎手術の周術期管理におけるクリニカルパスの使用と成績2011

    • Author(s)
      小川仁、柴田近, 他
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 潰瘍性大腸炎にチアする大腸全摘回腸嚢肛門吻合術後回腸嚢炎の臨床経過2010

    • Author(s)
      小川仁, ほか
    • Organizer
      潰瘍病態研究会第19回フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大腸全摘・回腸嚢肛門吻合術後Afferent Loop Syndromeの検討

    • Author(s)
      小川 仁
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-23 Regulates Gene Expressions via STAT3 Activation in the Human Intestinal Neuroendocrine Cell Line

    • Author(s)
      H. Suzuki
    • Organizer
      DDW2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-23はSTAT3を介して腸管の神経内分泌細胞に作用する

    • Author(s)
      鈴木 秀幸
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-23は直接的に大腸癌の増殖能・浸潤能を亢進させる

    • Author(s)
      鈴木 秀幸
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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