| Project/Area Number |
22591486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
|---|
| Research Institution | Osaka University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
ITOU Yoshinori 大阪大学, 医学系研究科, 教授 (20231152)
TAKEDA Kiyoshi 大阪大学, 医学系研究科, 教授 (20309446)
中島 清一 大阪大学, 学内共同利用施設等, 教授 (30432537)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | 炎症性腸疾患 / 免疫学 / Th17細胞 / 樹状細胞 |
|---|
| Research Abstract |
In the inflammatory site of inflammatory bowel diseases (IBD) patient, CD14+CD11c+ cells, which showed the morphology of macrophage and were double positive for a marker of monocyte (CD14) and a dendritic cells (CD11c), has significantly increased. In the non-inflammatory site, the popultation of CD14+CD11c+ cells was not significantly different from that in non-IBD patient. In lamina propria, Th17 cells were significantly induced by CD14+CD11c+ cells rather than CD14-CD11c+ cells and CD14-CD11c- cells
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