Resarch for the mechanisms of induction and differentiation of mucosal immune cells in the patients with inflammatory bowel diseases
| Project/Area Number |
22591486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITOU Yoshinori 大阪大学, 医学系研究科, 教授 (20231152)
TAKEDA Kiyoshi 大阪大学, 医学系研究科, 教授 (20309446)
中島 清一 大阪大学, 学内共同利用施設等, 教授 (30432537)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 炎症性腸疾患 / 免疫学 / Th17細胞 / 樹状細胞 |
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| Research Abstract |
In the inflammatory site of inflammatory bowel diseases (IBD) patient, CD14+CD11c+ cells, which showed the morphology of macrophage and were double positive for a marker of monocyte (CD14) and a dendritic cells (CD11c), has significantly increased. In the non-inflammatory site, the popultation of CD14+CD11c+ cells was not significantly different from that in non-IBD patient. In lamina propria, Th17 cells were significantly induced by CD14+CD11c+ cells rather than CD14-CD11c+ cells and CD14-CD11c- cells
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Shinzaki S Kuroki E, Iijima H, Tatsunaka N, Ishii M, Fujii H, Kamada Y, Kobayashi T, Shibukawa N, Inoue T, Tsujii M, Takeishi S, Mizushima T, Ogata A, Naka T, Plevy SE, Takehara T, Miyoshi E2013
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[Journal Article] Inoue T Iijima H, Tajiri M, Shinzaki S, Shiraishi E, Hiyama S, Mukai A, Nakajima S, Iwatani H, Nishida T, Mizushima T, Yasui T, Isaka Y, Kanto T, Tsujii M, Miyoshi E, Wada Y, Takehara T2012
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[Presentation] A case of Crohn's colitis-associated rectal cancer following after sporadic adenocarcinoma in adenoma2012
Author(s)
Takeyama H. Mizushima T., Nakajima K., Takahashi H., Nishimura J., Takemasa I., Ikeda M., Yamamoto H., Sekimoto M., Nezu R., Ito T., Doki Y., Mori M
Organizer
6th Korea-Japan IBD Symposium
Place of Presentation
Tokyo
Year and Date
2012-01-28
Related Report
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