Identification of the marker for cholangiocarcinoma based on the data by proteomics and tissue microarray
| Project/Area Number |
22591511
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
HIRANO Satoshi 北海道大学, 大学院・医学研究科, 教授 (50322813)
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIKAWA Takahiro 北海道大学, 大学病院, 助教 (50507572)
NAKAMURA Toru 北海道大学, 大学院・医学研究科, 助教 (70645796)
宮本 正樹 北海道大学, 大学病院, 助教 (40333611)
近藤 哲 北海道大学, 大学院・医学研究科, 教授 (30215454)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 胆道癌 / tissue micro array / プロテオミクス / tisssue micro array / 腫瘍マーカー / 生存率 / TMA解析 / マーカー |
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| Research Abstract |
We analyzed resected specimens by the proteomics approach anddetected 4 unique proteins (actinin-1,actinin-4,DJ-1,cathepsin B) out of 38 higher gene expression products compared with normal bile duct tissue. Next,we evaluated theexpression level of these 4 proteins by Western blotting method among 19 bile ductcarcinoma cell lines and characterized them into low expression cell lines and highexpression cell lines. We Finally, we performed immunohistochemical analysisutilizing tissue micro array of the consecutive 96 resected specimens of bile ductcarcinoma Among 4 proteins, high expression of DJ-1 could be a marker to suggestgood prognosis (p=0604)
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Report
(4 results)
Research Products
(10 results)
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[Presentation] Clinical efficacy of adjuvant surgery following systemic treatments in patients with initially unresectable pancreatic cancer: Results of a project study for pancreatic surgery by the Japanese society of hepato-biliary-pancreatic surgery2013
Author(s)
Hirano S, Satoi S, Yamaue H, Kato K, Takahashi S, Takeda S, Eguchi H, Sho M, Wada K, Shinichi H, Kwon H, Kinoshita T, Nakao A, Nagano H, Nakajima Y, Sano K, Miyazaki M, Takada T
Organizer
Gastrointestinal Cancers Symposium (ASCO)
Place of Presentation
USA,The Moscone west Building
Related Report
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[Presentation] Distal pancreatectomy with en bloc celiac axis resection (DP-CAR) followed by adjuvant therapy as a novel strategy for advanced pancreatic body cancer2011
Author(s)
Hirano S, Kondo S, Miura T, Takada M, Tamoto E, Teramoto K, Murakami S, Kato K, Matsumoto J, Tsuchikawa T, Shichinohe T, Tanaka E
Organizer
第111日本外科学会
Place of Presentation
(東京都)東京国際フォーラム予定
Related Report
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