Contribution of The Pro-inflammatory Cytokines and Aquaporin 1 & 4 in the Progression

Research Project

Project/Area Number	22591622
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	Kanazawa Medical University
Principal Investigator	TACHIBANA Osamu 金沢医科大学, 医学部, 教授 (40211362)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	ラトケ嚢胞 / 炎症性サイトカイン / アクアポリン / ホルモン受容体 / サイトカイン / 炎症
Research Abstract	Expression of water-channel aquoporin 1 and 4 in Rathke epithelium might stimulate to progression of cyst. Over-expression of androgen receptor in Rathke epithelium might induce proliferation with Rathke epithelium itself and inflammation in adenohypophysis. So aquaporin and androgen receptor might be novel target molecules totreat with symptomatic Rathke cleft cyst.

Report

(4 results)