Involvement of oxidative stress and endoplasmic reticulum stress inthe pathogenesis of cartilage degeneration
| Project/Area Number |
22591659
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
HIROSE Jun 熊本大学, 医学部附属病院, 講師 (40433007)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTA Hirosi 熊本大学, 大学院・生命科学研究部, 教授 (60174025)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 軟骨変性 / 酸化ストレス / 小胞体ストレス / カルボニルストレス |
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| Research Abstract |
To clarify the relationship of oxidative stress, carbonyl stress and endoplasmicreticulum stress in the pathogenesis of cartilage degeneration, we evaluated the roleof the three stresses on chondrocyte function and apoptosis. In cultured rat articularchondrocytes, stimulation with or without suppression of each stress regulatedchondrocyte function and apoptosis. These reactions were involved with crosslink of thethree stresses. In the experiment of direct infusion of the inducers of each stress intorat knees, chondrocyte apoptosis and cartilage degeneration were increased; however, noconnections among these stresses could be found
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Report
(4 results)
Research Products
(5 results)
