Evaluation of NF-kb decoy transfer using extracorporeal shock wave for arthritis model

• Project/Area Number: 22591676
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Chiba University
• Principal Investigator: OCHIAI Nobuyasu 千葉大学, 大学院・医学研究院, 助教 (40400931)
• Co-Investigator(Kenkyū-buntansha): OHTORI Seiji 千葉大学, 医学部附属病院, 講師 (40361430)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 関節病学 / 体外衝撃波 / 関節炎 / Nuclear factor-kb decoy / Nuclear Factor-kb decoy

Research Abstract

Treatment using nuclear factor-kB decoy (NF-kB decoy) and extracorporeal shock wave therapy (ESWT) were evaluated. Our data showed that ESWT and NF-kB decoy suppressed the inflammation. Furthermore, both treatments would have synergism for the treatment of arthritis model.

Research Products

• [Journal Article] Radial shock waves effectively introduced NF-kappa B decoy into rat achilles tendon cells in vitro (2010)
  • Author(s): Sugioka K, Nakagawa K, Murata R, Ochiai N, Sasho T, Arai M, Tsuruoka H, Ohtori S, Saisu T, Gemba T, Takahashi K
  • Journal Title: J Orthop Res Volume: 28(8) Issue: 8 Pages: 1078-83
  • DOI: 10.1002/jor.21081
  • Peer Reviewed
• [Journal Article] Radial shock waves effectively introduced NF-kappa Bdecoy intorat achilles tendon cellsin vitro. (2010)
  • Author(s): ugioka K, Ochiai N, Ohtori S
  • Journal Title: Journal of Orthopaedic Research Volume: 28 Pages: 1078-1083
  • Peer Reviewed