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The analysis of the mechanisms by which volatile anesthetics and propofol induce apoptosis of immune cells.

Research Project

Project/Area Number 22591702
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTohoku University

Principal Investigator

KUROSAWA Shin  東北大学, 病院, 准教授 (60272043)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords麻酔学 / 麻酔科学
Research Abstract

In this study, volatile anesthetics induced thymocyte apoptosis and reduced mitochindrial membrane potential in thymocytes dose- and time-dependently. In addition, the reduction of mitochondrial membrane potential preceded the induction of thymocyte apoptosis. Probably, reduction of mitochondrial membrane potential in thymocytes is one of the initial events.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 12 results) Presentation (16 results) Book (1 results)

  • [Journal Article] Anesthesia in patients with cancer disorders2012

    • Author(s)
      Shin Kurosawa
    • Journal Title

      Current Opinion in Anesthesiology

      Volume: Vol.25-No.3 Issue: 3 Pages: 376-384

    • DOI

      10.1097/aco.0b013e328352b4a8

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of changes of positive end-expiratory pressure on functional residual capacity at low tidal volume ventilation during general anesthesia2012

    • Author(s)
      Daizo Satoh、Shin Kurosawa、Wakaba Kirino、Toshihiro Wagatsuma、Yutaka Ejima、AkikoYoshida、Hiroaki Toyama、Kei Nagaya
    • Journal Title

      J. Anesthesia

      Volume: Vol.26-No.5 Issue: 5 Pages: 664-669

    • DOI

      10.1007/s00540-012-1411-9

    • NAID

      10031123487

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Delayed Rectifier K+ Channels Promotes In situProliferation ofLeukocytes in Rat Kidneys with Advanced Chronic Renal Failure2012

    • Author(s)
      Itsuro Kazama、Yoshio Maruyama, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Mitsunobu Matsubara, Shin Kurosawa
    • Journal Title

      International Journal of Nephrology

      Volume: 1 Pages: 1-8

    • DOI

      10.1155/2012/581581

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical stress increases circulating endothelial microparticles in elderly2012

    • Author(s)
      T.Takahashi、H.Kubo、N.Fujino、T.Suzuki、 C.Ota 、 M.Yamada 、 M.Yamada 、 S.Suzuki 、 S.Kurosawa
    • Journal Title

      Anaesthesia and Intensive Care

      Volume: Vol.40-No.5 Pages: 899-902

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility2012

    • Author(s)
      Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, He M, Yamada M, Suzuki S, Yanai M, Kurosawa S, Yamaya M, Kubo H.
    • Journal Title

      Thorax

      Volume: 67 Issue: 12 Pages: 1067-1074

    • DOI

      10.1136/thoraxjnl-2011-201395

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Compensatory Thrombopoietin Production from the Liver and Bone Marrow Stimulates Thrombopoiesis of Living Rat Megakaryocytes in Chronic Renal Failure2012

    • Author(s)
      Etsuro Kazama、Yasuhiro Endo、Hiroaki Toyama 、 Yutaka Ejima 、 Shin Kurosawa 、 Yoshimichi Murata、Mitsunobu Matsubara、Yoshio Maruyama
    • Journal Title

      Nephron Extra

      Volume: Vol.1 Issue: 1 Pages: 147-156

    • DOI

      10.1159/000333018

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of actual tidal volume in neonatal lung model volume control ventilation using three ventilators2012

    • Author(s)
      Hiroaki Toyama、Yasuhiro Endo、Yutaka Ejima、Mitsunobu Matsubara、Shin Kurosawa
    • Journal Title

      Anaesthesia and Intensive Care

      Volume: Vol.39-No.4 Pages: 599-606

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired endothelial progenitor cell mobilization and colony-forming capacityin chronic obstructive pulmonary disease2012

    • Author(s)
      Toru Takahashi、Satoshi Suzuki、Hiroshi Kubo、Matsuo Yamaya、Shin Kurosawa、Masato Kato
    • Journal Title

      Respirology

      Volume: Vol.16-No.4 Issue: 4 Pages: 680-687

    • DOI

      10.1111/j.1440-1843.2011.01959.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 揮発性吸入麻酔薬とリンパ球アポトーシス2012

    • Author(s)
      西野涼、黒澤伸
    • Journal Title

      Anesthesia 21 century

      Volume: Vol.14-No.1 Pages: 4-10

    • Related Report
      2012 Final Research Report
  • [Journal Article] 麻酔管理と長期予後周術期管理と免疫機能2012

    • Author(s)
      黒澤伸
    • Journal Title

      Anesthesia 21 Century

      Volume: Vol.12-No.3 Pages: 12-21

    • Related Report
      2012 Final Research Report
  • [Journal Article] Higher fraction of inspired oxygen in anesthesia induction does not affect functional residual capacity reduction after intubation: a comparative study of higher and lower oxygen concentration.2012

    • Author(s)
      Akihiro Kanaya
    • Journal Title

      Journal of Anesthesia

      Volume: 26 Issue: 3 Pages: 1-8

    • DOI

      10.1007/s00540-012-1547-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical stress increases circulating endothelial microparticles in elderly.2012

    • Author(s)
      Toru Takahashi
    • Journal Title

      Anaesthesia and Intensive Care

      Volume: 40 Pages: 899-902

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Remifentanil use for cesarean section in a patient with intracranial re-ruptured arteriovenous malformation2012

    • Author(s)
      Eiko Onishi
    • Journal Title

      Journal of Anesthesia

      Volume: 26 Issue: 2 Pages: 275-279

    • DOI

      10.1007/s00540-011-1295-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 揮発性吸入麻酔薬とリンパ球アポトーシス2012

    • Author(s)
      西野涼、黒澤伸
    • Journal Title

      Anesthesia 21 Century

      Volume: 14 Pages: 4-10

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Comparison of actual tidal volume in neonate lung model volume control ventilation using three ventilators2011

    • Author(s)
      Hiroaki Toyama, Shin Kurosawa
    • Journal Title

      Anaesthesia and Intensive Care

      Volume: 39 Pages: 599-606

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Thevolatile anesthetics isoflurane and sevoflurane affect glucose-stimulated insulin secretion in the pancreatic beta cell line MIN62012

    • Author(s)
      Kengo Suzuki、Hiroki Daijo、Shinichi Kai、 Tomonori Matsuyama 、 Shin Kurosawa 、 Kazuhiko Fukuda 、 Kiichi Hirota
    • Organizer
      American society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Washington, DC(米国)
    • Year and Date
      2012-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of intraoperative glucose and amino acid administration on energy requirement of patients during general anesthesia2012

    • Author(s)
      Tomoko Takahashi
    • Organizer
      American society of Anesthesiologists
    • Place of Presentation
      Washington, D.C. 米国
    • Related Report
      2012 Annual Research Report
  • [Presentation] Low incidence of emergence agitation in children after propofol anesthesia as compared with sevoflurane: A meta-analysis of randomized controlled trials.2012

    • Author(s)
      Akihiro Kanaya
    • Organizer
      American society of Anesthesiologists
    • Place of Presentation
      Washington, D.C. 米国
    • Related Report
      2012 Annual Research Report
  • [Presentation] The volatile anesthetics isoflurane and sevoflurane affect glucose-stimulated insulin secretion in the pancreatic beta cell line MIN62012

    • Author(s)
      Kengo Suzuki
    • Organizer
      American society of Anesthesiologists
    • Place of Presentation
      Washington, D.C. 米国
    • Related Report
      2012 Annual Research Report
  • [Presentation] 伸免疫能と麻酔管理2011

    • Author(s)
      黒澤
    • Organizer
      第31回日本臨床麻酔学会
    • Place of Presentation
      那覇
    • Year and Date
      2011-11-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 免疫能と麻酔管理2011

    • Author(s)
      黒澤伸
    • Organizer
      日本臨床麻酔学会第31回学術集会
    • Place of Presentation
      那覇(招待講演)
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thoracic Surgery-induced Increase in Circulating Endothelial Microparticle Release in Elderly Patients2011

    • Author(s)
      Toru Takahashi、Hiroshi Kubo、Satoshi Suzuki 、 Shin Kurosawa
    • Organizer
      American Society ofAnesthesiologists Annual Meeting
    • Place of Presentation
      Chicago(米国)
    • Year and Date
      2011-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Differential Role of Prostaglandin E-type Receptors in Activation of Hypoxia-inducible Factor 1by Prostaglandine E1 in Vascular-derived Cell under Non-hypoxic Conditions2011

    • Author(s)
      Kengo Suzuki、Satoshi Takabuchi、Hiroki Daijo、Shinichi Kai、Tomonori Matsuyama、 Shin Kurosawa
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Chicago(米国)
    • Year and Date
      2011-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Propofol Promotes Gulucocorticoids-induced Apoptosis of Murine Thymocytes in Vitro2011

    • Author(s)
      Noriko Toda、Shin Kurosawa、Kengo Suzuki、Wakaba Kirino 、 Yuko Saito
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Chicago(米国)
    • Year and Date
      2011-10-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 揮発性吸入麻酔薬による免疫細胞毒性の解析ー揮発性吸入麻酔薬はマウス胸腺細胞のミトコンドリア膜電位を低下させ、アポトーシスを誘導する2011

    • Author(s)
      黒澤伸
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] プロポフォールはマウス胸腺細胞のデキサメタゾン誘導性アポトーシスを増強する2011

    • Author(s)
      戸田法子、黒澤伸、齋藤浩二、吾妻俊弘、亀山良亘、小野寺尚子
    • Organizer
      日本麻酔科学会58回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 揮発性吸入麻酔薬による免疫細胞毒性の解析2011

    • Author(s)
      黒澤伸
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Endothelial Progenitor Cell Mobilization Was Impaired in Patients with Neoadjuvant Chemotherapy2010

    • Author(s)
      Toru Takahashi、Satoshi Suzuki、Shin Kurosawa、 Masato Kato、Hiroshi Kubo
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2010-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Volatile Anesthetics Promote Glucocorticoid-Induced Apoptosis of Murine Thymocytes In Vitro2010

    • Author(s)
      Noriko Toda、Shin Kurosawa、Toshihiro Wagatsuma、Hiroaki Toyama、Yutaka Ejima
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2010-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Volatile Anesthetics Promote Glucocorticoid-induced Apoptosis of Murine Thymocytes In Vitro2010

    • Author(s)
      黒澤伸
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      アメリカ合衆国サンジエゴ市
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 揮発性吸入麻酔薬はデキサメタゾンによるマウス胸腺細胞のアポトーシスを増強する2010

    • Author(s)
      戸田法子、黒澤伸、吾妻俊弘、齋藤浩二、吉田明子、長谷川淳一
    • Organizer
      第57回日本麻酔科学会学術集会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-04
    • Related Report
      2012 Final Research Report
  • [Book] 呼吸器研修ノート2011

    • Author(s)
      渋津雅和、黒澤伸
    • Publisher
      診断と治療社
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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