The effect of statin on the cardioprotective effects induced by volatile anesthetics during hyperglycemia

• Project/Area Number: 22591710
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: The University of Tokushima
• Principal Investigator: TANAKA Katsuya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263841)
• Co-Investigator(Kenkyū-buntansha): OSHITA Shuzo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60144945) ; TSUTSUMI Yasuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (90523499)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 吸入麻酔薬 / 心筋保護効果 / スタチン / 高血糖 / イソフルラン / 心筋保護

Research Abstract

Isoflurane-induced postconditioning and the reduced myocardialinfarct size induced by the short-term (3days) simvastatin administration are blocked by hyperglycemia. However, short-term simvastatin administration facilitates and restores isoflurane-induced postconditioning during hyperglycemia.

Research Products

• [Journal Article] 2012 年度学会賞記念講演:山村記念賞 麻酔薬や血管作動薬が血管平滑筋細胞と膵臓β細胞のATP 感受性K+チャネルに及ぼす影響 (2012)
  • Author(s): 田中克哉
  • Journal Title: 麻酔 Volume: 61巻
• [Journal Article] 2012年度学会賞記念講演：山村記念賞 麻酔薬や血管作動薬が血管平滑筋細胞と膵臓β細胞のATP感受性K+チャネルに及ぼす影響 (2012)
  • Author(s): 田中克哉
  • Journal Title: 麻酔 Volume: 61
• [Journal Article] Role of O-linked beta-N-acetylglucosamine in the cardioprotection induced by isoflurane (2011)
  • Author(s): Hirose K, Tsutsumi Y, Tanaka K, Oshita S, et al.
  • Journal Title: Anesthesiology Volume: Vol.115 Issue: 5 Pages: 955-962
  • DOI: 10.1097/aln.0b013e31822fcede
  • Peer Reviewed
• [Journal Article] a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/ PI3K (2011)
  • Author(s): Tsutsumi Y, Tanaka K, Oshita S, et al. Compound K
  • Journal Title: Life Sciences Volume: Vol.88 Issue: 15-16 Pages: 725-729
  • DOI: 10.1016/j.lfs.2011.02.011
  • Peer Reviewed
• [Journal Article] Differential effects of propofol and isoflurane on glucose utilization and insulin secretion (2011)
  • Author(s): Tanaka K, Tsutsumi Y, Oshita S, et al
  • Journal Title: Life Sciences Volume: Vol.88 Issue: 1-2 Pages: 96-103
  • DOI: 10.1016/j.lfs.2010.10.032
  • Peer Reviewed
• [Journal Article] Role of O-linked beta-N-acetylglucosamine in the cardioprotection induced by isoflurane (2011)
  • Author(s): Hirose K, et al
  • Journal Title: Anesthesiology Volume: 115 Pages: 955-962
  • Peer Reviewed
• [Journal Article] Differential effects of propofol and isoflurane on glucose utilization and insulin secretion. (2011)
  • Author(s): Tanaka K, Oshita S, et.al
  • Journal Title: Life Sciences Volume: 88 Pages: 96-103
  • Peer Reviewed
• [Presentation] 麻酔薬や血管作動薬が血管平滑筋細胞と膵臓β細胞のATP 感受性K+チャネルに及ぼす影響 (2012)
  • Author(s): 田中克哉
  • Organizer: 日本麻酔科学会第59回学術集会 (2012年度学会記念講演:山村記念講演)
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2012-06-07
• [Presentation] Hyperglycemia Impairs Cardioprotection by Volatile Anesthetics. (2011)
  • Author(s): 田中克哉
  • Organizer: 日本臨床麻酔学会第30回大会
  • Place of Presentation: 徳島市
  • Year and Date: 2011-11-04
• [Presentation] Effects of volatile anesthetics on ATP-sensitive K+ channels in various tissues (2011)
  • Author(s): 田中克哉
  • Organizer: 日中麻酔科学会議シンポジウム(招待講演)
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県)
  • Year and Date: 2011-11-03
• [Presentation] Effects of volatile anesthetics on ATP-sensitive K+ channels in various tissues (2011)
  • Author(s): 田中克哉
  • Organizer: 日中麻酔科学会議シンポジウム
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県)(招待講演)
  • Year and Date: 2011-11-03
• [Presentation] Simvastatin restores anesthetic postconditioning in the presence of hyperglycemia in vivo rabbits (2011)
  • Author(s): Katsuya Tanaka, et al
  • Organizer: American Society of Anesthesiologists 2011 Annual Meeting
  • Place of Presentation: McCormick Place (Chicago, USA)
  • Year and Date: 2011-10-16
• [Presentation] Simvastatin restores anesthetic postconditioning in the presence of hyperglycemia in vivo rabbits (2011)
  • Author(s): Katsuya Tanaka, et al
  • Organizer: American Society of Anesthesiologists 2011 Annual Meeting
  • Place of Presentation: McCormick Place (Chicago)
  • Year and Date: 2011-10-16
• [Presentation] Hyperglycemia impairs cardioprotection by volatile anesthetics (2010)
  • Author(s): 田中克哉
  • Organizer: 日本臨床麻酔学会第30回大会
  • Place of Presentation: 徳島グランヴィリオホテル(徳島県)
  • Year and Date: 2010-11-04
• [Presentation] 2012年度学会賞記念講演：山村記念賞 麻酔薬や血管作動薬が血管平滑筋細胞と膵臓β細胞のATP感受性K+チャネルに及ぼす影響
  • Author(s): 田中克哉
  • Organizer: 日本麻酔科学会第５９回学術集会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県）
  • Invited
• [Book] 徹底ガイド 心臓麻酔Q&A [新装版] Q18 心臓手術中の心筋保護 (2013)
  • Author(s): 田中克哉 堤 保夫 大下修造
  • Publisher: 総合医学社
• [Book] 徹底ガイド 心臓麻酔Q&A [新装版] Q18 心臓手術中の心筋保護 (2013)
  • Author(s): 田中克哉
  • Publisher: 総合医学社
• [Book] セボフルラン -基礎を知れば臨床がわかる- 第9章 セボフルランの抗炎症効果と臓器保護効果 (2010)
  • Author(s): 田中克哉
  • Publisher: メディカル・サイエンス・インターナショナル社
• [Book] セボフルラン-基礎を知れば臨床がわかる-第9章セボフルランの抗炎症作用と臓器保護効果 (2010)
  • Author(s): 田中克哉(稲田英一編集)
  • Total Pages: 20
  • Publisher: メディカル・サイエンス・インターナショナル社
• [Remarks]
  • URL: http://pub2.db.tokushima-u.ac.jp/ERD/person/60304/work-ja.html
• [Remarks] 徳島大学/教育研究者総覧 田中克哉
• [Remarks]
  • URL: http://www.med.tokushima-u.ac.jp/article/0017600.html
• [Remarks]
  • URL: http://www.med.tokushima-u.ac.jp/article/0017600.html