Elucidation of role of Rho-kinase in the post resuscitation syndrome

• Project/Area Number: 22591738
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: YOSHITOMI Osamu 長崎大学, 大学病院, 助教 (30380926)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心筋虚血再灌流障害 / 心筋スタニング / α_2アドレナリン受容体刺激薬 / phosphodiesterase-III阻害薬 / Rho-kinase阻害薬 / p38MAPK / 再灌流性不整脈 / α2-adrenergic agonist / カテコラミン / ホスホジエステラーゼIII阻害薬 / カルシウム感受性増強薬 / 薬理学的プレコンディショニング / 心筋梗塞サイズ / 水素 / ボスホジエステラーゼIII阻害薬 / 好中球エラスターゼ阻害薬 / サイトカイン

Research Abstract

Myocardial reperfusion injury is said to be an important factor of the postresuscitation myocardial dysfunction. The pharmacological control for the myocardial ischemiareperfusion injury leads to conquest of the postresuscitation myocardial dysfunction.

Research Products

• [Journal Article] Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine (2013)
  • Author(s): Shibata I, Cho S, Yoshitomi O, Ureshino H, Maekawa T, Hara T, Sumikawa K
  • Journal Title: Scand Cardiovasc J Volume: 47(1) Pages: 50-7
  • NAID: 120006985770
  • Peer Reviewed
• [Journal Article] Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine. (2013)
  • Author(s): Itsuko Shibata
  • Journal Title: Scand Cardiovasc J Volume: 47 Pages: 50-57
  • Peer Reviewed
• [Journal Article] Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs (2012)
  • Author(s): Yoshitomi O, Cho S, Hara T, Shibata I, Maekawa T, Ureshino H, Sumikawa K.
  • Journal Title: Shock Volume: 38(1) Pages: 92-7
  • NAID: 120006985371
  • Peer Reviewed
• [Journal Article] A new technique for post-pyloric feeding tube placement by palpation in lean critically ill patients (2012)
  • Author(s): Sekino M, Yoshitomi O, Nakamura T, Makita T, Sumikawa K
  • Journal Title: Anaesth Intensive Care Volume: 40(1) Pages: 154-8
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine (2012)
  • Author(s): Sakai K, Cho S, Shibata I, Yoshitomi O, Maekawa T, Sumikawa K
  • Journal Title: Scand Cardiovasc J Volume: 46(3) Pages: 183-9
  • NAID: 120006985409
  • Peer Reviewed
• [Journal Article] Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs. (2012)
  • Author(s): Osamu Yoshitomi
  • Journal Title: Shock Volume: 38 Pages: 92-97
  • NAID: 120006985371
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine (2012)
  • Author(s): Kazuyuki Sakai
  • Journal Title: Scand Cardiovasc J Volume: 20
  • Peer Reviewed
• [Journal Article] Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine (2010)
  • Author(s): Akiyama D, Hara T, Yoshitomi O, Maekawa T, Cho S, Sumikawa K
  • Journal Title: J Anesth Volume: 24(4) Pages: 575-81
  • NAID: 10026632664
  • Peer Reviewed
• [Journal Article] A p38 MAPK inhibitor, SB203580, blocks cardioprotective effect of post-ischemic administration of milrinone against myocardial stunning in swine (2010)
  • Author(s): Shibata I, Yo shi t o mi O, Sakai K, Maekawa T, Cho S, Sumikawa K
  • Journal Title: Anesthesiology Volume: 113
  • Peer Reviewed
• [Journal Article] A p38 MAPK inhibitor blocks cardioprotective effect of post-ischemic administration of milrinone. (2010)
  • Author(s): Itsuko Shibata
  • Journal Title: Anesthesiology Volume: 113
  • Peer Reviewed
• [Journal Article] Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine. (2010)
  • Author(s): Daiji Akiyama
  • Journal Title: J.Anesth Volume: 24 Pages: 575-81
  • Peer Reviewed
• [Presentation] 心室細動を来した術中急性冠症候群の1例 (2012)
  • Author(s): 吉富 修
  • Organizer: 日本蘇生学会
  • Place of Presentation: 大津
• [Presentation] 心・大血管手術後の難治性頻脈に関わる因子について-塩酸ランジオロール使用量からの検討- (2011)
  • Author(s): 吉富 修
  • Organizer: 日本集中治療医学会
  • Place of Presentation: 横浜
• [Presentation] 血液型不適合生体肝移植後に血栓性微小血管障害(thrombotic microangiopathy: TMA)を発症した1例 (2010)
  • Author(s): 吉富 修
  • Organizer: 日本集中治療医学会学術集会
  • Place of Presentation: 広島
• [Presentation] 塩酸ランジオロールを使用した心・大血管手術後症例の検討 (2010)
  • Author(s): 吉富 修
  • Organizer: 長崎周術期管理研究会
  • Place of Presentation: 長崎