The role of glial cell in cancer pain, for a new strategy of cancer pain.

• Project/Area Number: 22591757
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: National Cancer Center Japan (2011-2012); Research Institute, International Medical Center of Japan (2010)
• Principal Investigator: SAITO Osamu 独立行政法人国立がん研究センター, 中央病院, 医長 (90344986)
• Co-Investigator(Renkei-kenkyūsha): AOE Tomohiko 千葉大学, 大学院・医学研究院, 准教授 (90311612) ; YAMAMOTO Tatsuo 熊本大学, 大学院・医学薬学研究院, 教授 (20200818)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 疼痛管理学(がん性疼痛・緩和医療 / 骨転移 / 疼痛 / 緩和医療 / 鎮痛薬 / グリア / がん性疼痛 / 疼痛管理 / グリア細胞 / サイトカイン

Research Abstract

It has been reported that ibudilast can attenuate some kinds of pain, due to its potential as a glial cell modulator. Our study reported it could attenuate bone cancer pain in a mouse model. The result suggests that ibudilast could be useful for the treatment of bone cancer pain.

Research Products

• [Journal Article] 抗真菌薬との薬物間相互作用で, 少量ケタミンがせん妄を惹起したと思われる1 例 (2012)
  • Author(s): 齊藤理, 赤木徹, 竜野真維, 他
  • Journal Title: Palliative Care Research Volume: 7(1)(主要論文執筆中) Pages: 506-9
  • NAID: 130002084806
• [Journal Article] がん疼痛患者における複方オキシコドン注射液の使用状況に関する調査 (2012)
  • Author(s): 佐野智望, 赤木徹, 横手信昭, 周東千緒,工藤尚子, 三浦耕資, 村上敏史, 齊藤理, 山本弘史, 的場元弘
  • Journal Title: 癌と化学療法 Volume: 39(5)(主要論文執筆中) Pages: 769-775
• [Journal Article] A small amount of ketamine with oxycodone induced an acute hyperactive delirium due to voriconazole, a CYP3A4 inhibitor, in a case of multiple myeloma with cancer pain (2012)
  • Author(s): 齊藤理・赤木徹・竜野真維, 他
  • Journal Title: Palliative Care Research Volume: 7 Issue: 1 Pages: 506-509
  • DOI: 10.2512/jspm.7.506
  • NAID: 130002084806
  • ISSN: 1880-5302
  • Peer Reviewed
• [Presentation] Ibudilast can attenuate bone cancer pain in a mouse model (2013)
  • Author(s): SAITO O, YAMAMOTO T, AOE T
  • Organizer: Society for Neuroscience, 43rd annual meeting
  • Place of Presentation: San Diego,USA
• [Presentation] Ibudilast attenuates bone cancer pain (2013)
  • Author(s): 齊藤理
  • Organizer: 第４３回 アメリカ神経科学学会
  • Place of Presentation: San Diego, USA
• [Presentation] The Effects of Systemic Lidocaine in a Mouse Model of Bone Cancer Pain (2010)
  • Author(s): SAITO O, AOE T, YAMAMOTO T
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-16