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Analysis of the factors on male infertility and habitual abortion & their Applications to clinical medicine

Research Project

Project/Area Number 22591811
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionAsahikawa Medical College

Principal Investigator

MIYAMOTO Toshinobu  旭川医科大学, 医学部, 講師 (70360998)

Co-Investigator(Kenkyū-buntansha) SENGOKU Kazuo  旭川医科大学, 医学部, 教授 (30163124)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生殖医学 / azoospermia / SCOS / MA / SNP / 無精子症 / 減数分裂 / mutation / 不妊症 / SEPTIN12
Research Abstract

We identified the human HORMAD1 gene causing azoospermia by meiotic arrest. In Addition, We also identified the human LRWD1 gene causing azoospermia by SCOS and we demonstrated that the human SEPTIN12 is critical in azoospermia by MA and SCOS.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2013 2012 2011 2010

All Journal Article (19 results) (of which Peer Reviewed: 11 results) Presentation (10 results)

  • [Journal Article] Single-nucleotide polymorphisms in the LRWD1 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome2013

    • Author(s)
      Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, Namiki M, Sengoku K
    • Journal Title

      Andrologia

      Volume: 46 Issue: 3 Pages: 273-276

    • DOI

      10.1111/and.12077

    • Related Report
      2012 Final Research Report
  • [Journal Article] Clinicopathologic risk factors for recurrence of ovarian endometrioma following laparoscopic cystectomy2013

    • Author(s)
      Sengoku K, Miyamoto T, Horikawa M, Katayama H, Nishiwaki K, Kato Y, Kawanishi Y, Saijo Y.
    • Journal Title

      Acta Obstet Gynecol Scand

      Volume: 92(3) Issue: 3 Pages: 278-84

    • DOI

      10.1111/aogs.12051

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenic mutations in two families with congenital cataract identified with whole-exome sequencing2013

    • Author(s)
      Kondo Y, Saitsu H, Miyamoto T, Lee BJ, Nishiyama K, Nakashima M, Tsurusaki Y, Doi H, Miyake N, Kim JH, Yu YS, Matsumoto N
    • Journal Title

      Mol Vis

      Volume: 19 Pages: 384-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Study of the vulvar skin in healthy Japanese women: components of the stratum corneum and microbes2012

    • Author(s)
      Miyamoto T, Akiba S, Sato N, Fujimura T, Takagi Y, Kitahara T, Takema Y, Iizuka H, Sengoku K.
    • Journal Title

      Int J Dermatol

      Volume: 52 Issue: 12 Pages: 1500-1505

    • DOI

      10.1111/j.1365-4632.2012.05582.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients2012

    • Author(s)
      Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Horikawa M, Saijo Y, Sengoku K.
    • Journal Title

      Asian J Androl

      Volume: 14(4) Pages: 580-3

    • NAID

      120006580771

    • Related Report
      2012 Final Research Report
  • [Journal Article] Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men2012

    • Author(s)
      Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Horikawa M, Saijo Y, Sengoku K.
    • Journal Title

      J Assist Reprod Genet

      Volume: 29(1) Pages: 47-51

    • Related Report
      2012 Final Research Report
  • [Journal Article] Male infertility and its causes in human2012

    • Author(s)
      Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Sengoku K.
    • Journal Title

      Adv Urol 2012

      Volume: 2012 Pages: 384520-384520

    • DOI

      10.1155/2012/384520

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome2012

    • Author(s)
      Miyakawa H, Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, Namiki M, Sengoku K.
    • Journal Title

      J Androl

      Volume: 53(3) Pages: 483-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] A family of oculofaciocardiodental syndrome (OFCD) with a novel BCOR mutation and genomic rearrangements involving NHS2012

    • Author(s)
      Kondo Y, Saitsu H, Miyamoto T, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ryoo NK, Kim JH, Yu YS, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 57(3) Pages: 197-201

    • NAID

      10030712110

    • Related Report
      2012 Final Research Report
  • [Journal Article] Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients2012

    • Author(s)
      Miyamoto T, et al.
    • Journal Title

      Asian J Androl

      Volume: 14 Issue: 4 Pages: 580-583

    • DOI

      10.1038/aja.2011.180

    • NAID

      120006580771

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men.2012

    • Author(s)
      Miyamoto T
    • Journal Title

      J Assist Reprod Genet.

      Volume: 29 Issue: 1 Pages: 47-51

    • DOI

      10.1007/s10815-011-9679-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men2012

    • Author(s)
      Miyamoto T, et al.
    • Journal Title

      J Assist Reprod Genet

      Volume: 29 Pages: 47-51

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Male infertility and its causes in human2012

    • Author(s)
      Miyamoto T, et al.
    • Journal Title

      Adv Urol

      Volume: 2012 Pages: 384520-384520

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-Nucleotide Polymorphisms in the SEPTIN12 Gene May Be a Genetic Risk Factor for Japanese Patients with Sertoli Cell-Only Syndrome2011

    • Author(s)
      Miyakawa H, Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, Namiki M, Sengoku K
    • Journal Title

      J Androl

      Volume: (Epub ahead of print) Issue: 3 Pages: 483-487

    • DOI

      10.2164/jandrol.110.012146

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-Nucleotide Polymorphisms in the SEPTIN12 Gene May Be a Grenetic Risk Factor for Japanese Patients with Sertoli Cell-Only Syndrome2011

    • Author(s)
      Miyakawa H, Miyamoto T, et al.
    • Journal Title

      J Androl

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest2011

    • Author(s)
      Miyamoto T, et al.
    • Journal Title

      J Assist Reprod Genet

      Volume: 28 Pages: 743-746

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current concepts of human azoospermia and its causes.2010

    • Author(s)
      Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Sato H, et al.
    • Journal Title

      Reprod Med Biol

      Volume: 9 Pages: 121-127

    • NAID

      10027050484

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不妊と遺伝因子2010

    • Author(s)
      宮本敏伸、佐藤恒、千石一雄
    • Journal Title

      産婦人科の実際

      Volume: 59 Pages: 1959-1967

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 不妊への対応PCOSにおける排卵誘発法と問題点】経口薬2010

    • Author(s)
      千石一雄、佐藤恒、宮本敏伸
    • Journal Title

      産婦人科の実際

      Volume: 64 Pages: 157-161

    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト精子形成過程におけるヒト SEPTIN12 遺伝子の解析2012

    • Author(s)
      宮本 敏伸,宮川 博栄,岡部 公香,千石 一雄
    • Organizer
      日本生殖医学会
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト精子形成過程におけるヒト SEPTIN12 遺伝子の解析2012

    • Author(s)
      宮本 敏伸,宮川 博栄,千石 一雄
    • Organizer
      日本産婦人科学会
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト無精子症におけるヒトSEPTIN12遺伝子の解析2012

    • Author(s)
      宮本敏伸
    • Organizer
      日本産婦人科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト無精子症におけるヒトHOMAD1遺伝子の解析2012

    • Author(s)
      宮本敏伸
    • Organizer
      日本生殖医学会総会
    • Place of Presentation
      長崎市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト無精子症原因候補遺伝子であるSEPTIN12遺伝子の解析2011

    • Author(s)
      宮本敏伸
    • Organizer
      第56回日本生殖医学会学術講演会・総会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト精子形成過程におけるヒト HOMAD1 遺伝子の解析2011

    • Author(s)
      宮本 敏伸,宮川 博栄,岡部 公香,千石 一雄
    • Organizer
      日本生殖医学会
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト精子形成過程におけるヒト HOMAD1 遺伝子の解析2011

    • Author(s)
      宮本 敏伸,宮川 博栄,岡部 公香,千石 一雄
    • Organizer
      日本産婦人科学会
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト精子形成過程におけるヒト SEPTIN12 遺伝子の解析2011

    • Author(s)
      宮本 敏伸,宮川 博栄,岡部 公香,千石 一雄
    • Organizer
      日本生殖医学会
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト精子形成過程におけるヒト SEPTIN12 遺伝子の解析2011

    • Author(s)
      宮本 敏伸,宮川 博栄,千石 一雄
    • Organizer
      日本産婦人科学会
    • Related Report
      2012 Final Research Report
  • [Presentation] 当教室において同定されたヒト無精子症に関わる遺伝子群2010

    • Author(s)
      宮本敏伸
    • Organizer
      第62回日本産婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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