Clinical usefulness of human papillomavirus testing

• Project/Area Number: 22591846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Tsukuba
• Principal Investigator: MATSUMOTO Koji 筑波大学, 医学医療系, 准教授 (30302714)
• Co-Investigator(Renkei-kenkyūsha): YOSHIKAWA Hiroyuki 筑波大学, 医学医療系, 教授 (40158415)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ヒトパピローマウイルス / 子宮頸癌 / HPV / 子宮頸部上皮内腫瘍 / 子宮頸部異形成 / 中和抗体 / HPVタイプ / ヒトパピローマウイルスhuman papillomavirus(HPV) / 子宮頸癌cervical cancer / 子宮頸部上皮内腫瘍cervical intraepithelial neoplasia(CIN) / low-grade squamous intraepithelial lesion(LSIL)

Research Abstract

Infections by oncogenic human papillomaviruses (HPVs) are a major risk factor of cervical cancer. To evaluate the clinical usefulness of HPV DNA testing and serology, we analyzed follow-up data of 570 women with low-grade cervical lesions. Our findings suggested that HPV genotyping and antibody assays for women with low-grade cervical abnormalities may be useful for identifying populations at increased or decreased risk of disease progression.

Research Products

• [Journal Article] Human papillomavirus infection and risk for cervical cancer in Japan. (2013)
  • Author(s): Matsumoto K, Yoshikawa H
  • Journal Title: J Obstet Gynaecol Res Volume: 39(1) Issue: 1 Pages: 7-17
  • DOI: 10.1111/j.1447-0756.2012.01977.x
  • Peer Reviewed
• [Journal Article] Do neutralizing antibody responses generated by human papillomavirus infections favor a better outcome of low-grade cervical lesions? (2012)
  • Author(s): Ochi H, Matsumoto K, Kondo K, Oki A, Furuta R, Hirai Y, Yasugi T, Takatsuka N, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Kanda T, Yoshikawa H
  • Journal Title: J Med Virol Volume: 84(7) Issue: 7 Pages: 1128-1134
  • DOI: 10.1002/jmv.23258
  • Peer Reviewed
• [Journal Article] HLA Class II DRB1*1302 1 allele protects against progression to cervical intraepithelial neoplasia grade 3:A multicenter, prospective, cohort study. (2012)
  • Author(s): Matsumoto K, Maeda H, Oki A, Takatsuka N, Yasugi T, Furuta R, Hirata R, Mitsuhashi A, Fujii T, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H
  • Journal Title: Int J Gynecol Cancer Volume: 22(3) Issue: 3 Pages: 471-478
  • DOI: 10.1097/igc.0b013e3182439500
  • Peer Reviewed
• [Journal Article] Predicting the Progression of Cervical Precursor Lesions by Human Papillomavirus Genotyping : A Prospective Cohort Study (2011)
  • Author(s): Matsumoto K, Yoshikawa H, et al.
  • Journal Title: Int J Cancer Volume: 128 Issue: 12 Pages: 2898-2910
  • DOI: 10.1002/ijc.25630
  • Peer Reviewed
• [Journal Article] Predicting the Progression of Cervical Precursor Lesions by Human Papillomavirus Genotyping A Prospective Cohort Study (2011)
  • Author(s): Matsumoto K, Oki A, Furuta R, et. al.
  • Journal Title: International Journal of Cancer Volume: in press
  • Peer Reviewed
• [Journal Article] Tobacco Smoking and Regression of Low Grade Cervical Abnormalities (2010)
  • Author(s): Matsumoto K, Oki A, Furuta R, et. al.
  • Journal Title: Cancer Science Volume: 101 Pages: 2065-2073
  • NAID: 10027831777
  • Peer Reviewed
• [Journal Article] Interleukin-10-1082 Gene Polymorphism and Susceptibility to Cervical Cancer Among Japanese Women (2010)
  • Author(s): Matsumoto K, Oki A, Satoh T, et al.
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 40 Pages: 1113-1116
  • Peer Reviewed
• [Presentation] 要望講演 中央病理診断に基づく臨床研究:子宮頸部「LSIL/CIN1-2患者の多施設共同コホート研 究 」 (2012)
  • Author(s): 松本光司、吉川裕之
  • Organizer: 第51回日本臨床細胞学会秋期大会
  • Place of Presentation: 朱鷺メッセ、新潟
  • Year and Date: 2012-11-09
• [Presentation] LSIL・HSILトリアージのためのHPVタイピング検査の有用性 (2012)
  • Author(s): 松本光司、中村優子、島袋剛二、西出健、永井公洋、佐藤豊実、沖明典、吉川裕之
  • Organizer: 第64回日本産科婦人科学術講演会
  • Place of Presentation: 神戸ポートピアホテル、神戸
  • Year and Date: 2012-04-14
• [Presentation] LSIL/CIN1-2患者の多施設共同コホート研究 (2012)
  • Author(s): 松本光司、吉川裕之
  • Organizer: 第51回日本臨床細胞学会秋期大会
  • Place of Presentation: 新潟
  • Invited
• [Presentation] LSIL･HSILトリアージのためのHPVタイピング検査の有用性 (2012)
  • Author(s): 松本光司、中村優子ら
  • Organizer: 第64回日本産科婦人科学術講演会
  • Place of Presentation: 神戸
• [Presentation] ヒトパピローマウイルスのタイプとCIN3への進展リスク (2011)
  • Author(s): 松本光司、沖明典、八杉利治、平井康夫、古田玲子、三橋暁、藤井多久磨、岩坂剛、八重樫伸生、渡部洋、長井裕、吉川裕之
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: リーガロイヤルホテル大阪、大阪
  • Year and Date: 2011-08-29
• [Presentation] HPV16に対する血清中和抗体と子宮頚部前癌病変の消失・進展 (2011)
  • Author(s): 越智寛幸、松本光司、近藤一成、古田玲子、平井康夫、八杉利治、沖明典、吉川裕之
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: リーガロイヤルホテル大阪、大阪
  • Year and Date: 2011-08-29
• [Presentation] 学術奨励賞受賞講演「我が国におけるHPV感染と子宮頚部発癌のリスク」 (2011)
  • Author(s): 松本光司
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: 大阪国際会議場(招待講演)
  • Year and Date: 2011-08-29
• [Presentation] ヒトパピローマウイルス遺伝子型と子宮頸部前癌病変の進展リスク (2010)
  • Author(s): 松本光司、沖明典、古田玲子, ほか
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪