Effects of endocrinological and immunological factors on metabolism in women during the menopausal transition
| Project/Area Number |
22591857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YASUI Toshiyuki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40230205)
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| Co-Investigator(Kenkyū-buntansha) |
IRAHARA Minoru 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20160070)
YAMAMOTO Satoshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (40346599)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 閉経 / 内分泌 / 免疫 / 代謝 / 周閉経期 / エストロゲン / テストステロン / インスリン抵抗性 / 性ステロイドホルモン結合グロブリン / サイトカイン / anti-Mullerian hormone |
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| Research Abstract |
The changes in estrogen and FSH during the menopausal transition were associated with increases in IL-8 and MCP-1 which were involved in the early stage of atherosclerosis. In addition, the change in testosterone was associatedwith the changes in adiponectin and NT-proBNP related to insulin sensitivity. These patterns in women with natural menopause were similar to those in women with GnRH agonist treatment. The changes during the menopausal transition may be associated with the occurrence of insulin resistance and atherosclerosis, partly be involved in the protective effect of these diseases.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Changes in insulin sensitivity during GnRH agonist treatment in premenopausal women with leiomyoma2012
Author(s)
Matsui S, Yasui T, Tani A, Kunimi K, Uemura H, Yamamoto S, Kuwahara A, Matsuzaki T, Tsuchiya N, Yuzurihara M, Kase Y, Irahara M.
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Journal Title
Clin Chim Acta
Volume: 413(11-12)
Issue: 11-12
Pages: 960-965
DOI
Related Report
Peer Reviewed
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