EMT including cancer stem cells regulates invasion and metastasis of uterine endometrial cancer.
| Project/Area Number |
22591869
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
TERAI Yoshito 大阪医科大学, 医学部, 准教授 (90278531)
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| Co-Investigator(Kenkyū-buntansha) |
OHMICHI Masahide 大阪医科大学, 医学部, 教授 (10283764)
TANABE Akiko 大阪医科大学, 医学部, 助教 (70454543)
KANEMURA Masanori 大阪医科大学, 医学部, 講師 (40298782)
SASAKI Hiroshi 大阪医科大学, 医学部, 助教 (80432491)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮内膜癌 / 幹細胞 / EMT / 薬剤耐性 / 浸潤・転移 / 癌幹細胞 / CD24 / Snail / E-cadherin / 婦人科癌 / E-chadherin / Epithelial Mesenchymal Transition / E-cadherino / Slug / EMT現象 |
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| Research Abstract |
E-cadherin and nuclear expression of Snail and Slug have a prognositic impact in endometrial cancer. CD24 correlated with EMT status in endometrial cancer. Therefore, to clarify and control of EMT signaling is a promising molecular targeting therapy inendometrial cancer.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer.2011
Author(s)
Tanaka Y, Terai Y*, Tanabe A, Sasaki H, Sekijima T, Fujiwara S, Yamashita Y, Kanemura M, Ueda M, Sugita M, Franklin WA, Ohmichi M.
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Journal Title
Cancer Biol Ther
Volume: 11
Pages: 50-57
Related Report
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