| Project/Area Number |
22591885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Masashi 大分大学, 医学部, 教授 (60211314)
前田 一彦 大分大学, 医学部, 助教 (70527738)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 中耳 / 慢性炎症 / インフルエンザ菌 / T 細胞 / 粘膜免疫 / 中耳炎 / Th17細胞 / 制御性T細胞 / 自然免疫 / 慢性中耳炎 / 慢性感染 |
|---|
| Research Abstract |
Nontypeable Haemophilus influenzae (NTHi) is considered a major pathogen underlying middle ear infection. This study aimed to investigate the dynamics of IL-17 in chronic otitis media induced by NTHi in Balb/c mice. NTHi was injected into the tympanic bulla with Eustachian tubal obstruction. Middle ear effusions and tissues were collected at day 3, 14, 2 month after injection. The concentration of IL-17 in middle ear effusions eleveated significantly during experiments when compared to control. IL-17 producing ・・ T cells and Th17 cells were also increased up to 6 months in the middle ear. Based on these findings, IL-17 producing T cells existed in chronic state of otitis media, and may play some role for modification of chronic inflammation in the middle ear.
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