Elucidation of pathological condition in uveitis using newly developed carbohydrate structural analysis; Glycoblottoing
| Project/Area Number |
22591927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
NANBA Kenichi 北海道大学, 北海道大学病院, 講師 (70333599)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Shinichirou 北海道大学, 先端生命科学研究院, 教授 (00183898)
KITAICHI Nobuyoshi 北海道大学, 大学院・医学研究科, 客員准教授 (40431366)
AMANO Maho 北海道大学, 先端生命科学研究科(研究院), 特任助教 (80365808)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | グライコミクス / ぶどう膜炎 / 糖鎖 / グライコプロッティング / EAU / 実験的自己免疫性ぶどう膜網膜炎 / ベーチェット病 / グライコブロッティング |
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| Research Abstract |
Glycoblottoing which was newly developed carbohydrate structural analysis was performed in uveitis patients. In the serum of uveitis patients, total amount of carbohydrate was increased in uveitis patients, and 3 carbohydrate chains that amount were changed in the active stage were found. In Behcet’s disease, carbohydrate chains that were associated with HLA-B51 or exraocular manifestations were found, however carbohydrate chains that were associated with ocular inflammatory attacks were not found. In mouse model experimental autoimmune uveoretinitis, carbohydrate chains that were changed with immunization were found, but they were not specific changes associated with induced uveitis.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.2012
Author(s)
Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S.
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Journal Title
Mol Vis.
Volume: 18
Pages: 2586-2597
NAID
Related Report
Peer Reviewed
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[Journal Article] Multicenter study of infliximab for refractory uveoretinitis in Behcet disease.2012
Author(s)
Okada AA, Goto H, Ohno S, Mochizuki M, Kitaichi N, Namba K, Keino H, Watanabe T, Ishibashi T, Ito T, Sonoda K, Nakai K, Ohguro N, Sugita S, Kezuka T, Kaburaki T, Takamoto M, Mizuki N.
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Journal Title
Arch Ophthalmol.
Volume: 130
Issue: 5
Pages: 592-598
DOI
Related Report
Peer Reviewed
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[Journal Article] Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients.2012
Author(s)
Sakuyama K, Meguro A, Ota M, Ishihara M, Uemoto R, Ito H, Okada E, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Yuasa T, Ohno S, Inoko H, Mizuki N.
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Journal Title
Mol Vis.
Volume: 18
Pages: 512-518
Related Report
Peer Reviewed
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[Journal Article] Toll-like receptor2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.2011
Author(s)
Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N.
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Journal Title
Mol Vis.
Volume: 17
Pages: 731-736
Related Report
Peer Reviewed
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[Journal Article] Genome-wide association studies identify IL23R/IL12RB2 and IL10 as Behcet's disease susceptibility loci.2010
Author(s)
Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Ito N, Kera J, Okada E, Yatsu K, Song YW, Lee EB, Kitaichi N, Namba K, Horie Y, Takeno M, Sugita S, Mochizuki M, Bahram S, Ishigatsubo Y, Inoko H
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Journal Title
Nat Genet
Volume: 42
Pages: 706-706
Related Report
Peer Reviewed
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[Journal Article] A randomized, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis.2010
Author(s)
Ohashi Y, Ebihara N, Fujishima H, Fukushima A, Kumagai N, Nakagawa Y, Namba K, Okamoto S, Shoji J, Takamura E, Hayashi K
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Journal Title
J Ocul Pharmacol Ther
Volume: 26
Pages: 165-174
Related Report
Peer Reviewed
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[Presentation] Amelioration of endotoxin-induced uveitis treated with an IkappaB kinase beta inhibitor2012
Author(s)
Kitaichi N, Lennikov A, Namba K, Noda K, Kanda A, Ando R, Dong Z, Fukuhara J, Kinoshita S, Ohno S, Ishida S.
Organizer
8th International Symposium on Uveitis
Place of Presentation
Sani Beach Resort（ Greece）
Related Report
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[Presentation] Amelioration of experimental autoimmune uveoretinitis by inhibiton of Glyceraldehide-derived AGEs formation2012
Author(s)
Kitaichi N, Dong Z, Iwata D, Takeuchi M, Namba K, Noda K, Kanda A, Iwabuchi K, Yamagishi S, Ohno S, Ishida S
Organizer
15th International Conference on Behcet's Disease
Place of Presentation
横浜コンベンションセンター（横浜市）
Related Report
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[Presentation] Trabecular depigmentation in convalescent stage of VKH disease2011
Author(s)
Ohno S, Mizuuchi K, Namba K, Kitaichi N, Horie Y
Organizer
The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
Place of Presentation
Taj Exotica Goa(India)
Year and Date
2011-11-14
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[Presentation] Effect of sufatide, a ligand for a subset of NKT cells, in experimental autoimmune uveoretinitis (EAU) in mice.2010
Author(s)
Iwata D, Ebihara A, Kitaichi N, Namba K, Ohno S,Iwabuchi K, Onoe K, Ishida S
Organizer
WOC (World Ophthalmology Congress)
Place of Presentation
International Congress Centrum Berlin (Berlin, Germany)
Year and Date
2010-06-05
Related Report
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