Promyelocytic leukemia tumor suppressor as therapeutic agent for diabetic retinopathy

• Project/Area Number: 22591929
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: The University of Tokushima
• Principal Investigator: MITAMURA Yoshinori 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30287536)
• Co-Investigator(Kenkyū-buntansha): NAGASAWA Toshihiko 徳島大学, 病院, 助教 (00511338) ; KATOME Takashi 徳島大学, 病院, 助教 (50464342)
• Co-Investigator(Renkei-kenkyūsha): HARADA Takayuki 公益財団法人東京都医学総合研究所, 視覚 病態プロジェクト, 副参事研究員 (90345306)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 外科 / 細胞・組織 / 生体分子 / 糖尿病 / 臨床

Research Abstract

Promyelocytic leukemia tumor suppressor (PML) mRNA expression levels in membrane samples, and the PML protein concentrations in aqueous humor and vitreous fluid samples were significantly lower in PDR patientsthan control patients. We observed a statistically significant inverse correlation between the concentrations of PML and vascular endothelial growth factor in the aqueous humor and vitreous fluid of PDR patients. Taken together, PML may be a good candidate as a diagnostic marker and a therapeutic agent for PDR.

Research Products

• [Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury. (2013)
  • Author(s): Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T.
  • Journal Title: Cell Death Differ. Volume: 20 Issue: 2 Pages: 270-280
  • DOI: 10.1038/cdd.2012.122
  • Peer Reviewed
• [Journal Article] Photoreceptor impairment and restoration on optical coherence tomographic image. (2013)
  • Author(s): Mitamura Y, et al.
  • Journal Title: J Ophthalmol Volume: Volume 2013 Pages: 1-7
  • DOI: 10.1155/2013/518170
  • Peer Reviewed
• [Journal Article] Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy (2012)
  • Author(s): Katome T、Namekata 、Naito T、Semba K、Guo X、Harada C、Harada T、Mitamura Y
  • Journal Title: Diabetes Res Clin Pract Volume: 98
  • Peer Reviewed
• [Journal Article] Quantitative analysis of cystoid macular edema using scanning laser ophthalmoscope in modified dark-field imaging (2012)
  • Author(s): Katome T、Mitamura Y、Nagasawa T、Eguchi H, Naito T
  • Journal Title: Retina Volume: 32 Issue: 9 Pages: 1892-1899
  • DOI: 10.1097/iae.0b013e3182497141
  • Peer Reviewed
• [Journal Article] Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy. (2012)
  • Author(s): Katome T, et al.
  • Journal Title: Diabetes Res Clin Pract Volume: 98 Issue: 2 Pages: 9-11
  • DOI: 10.1016/j.diabres.2012.09.020
  • Peer Reviewed
• [Journal Article] Diagnostic imaging in patients with retinitis pigmentosa (2012)
  • Author(s): Mitamura Y, et al
  • Journal Title: J Med Invest Volume: 59 Pages: 1-11
  • NAID: 130004465252
  • Peer Reviewed
• [Journal Article] Foveal microstructure on spectral-domam optical coherence tomographic images and visual function after macular hole surgery (2011)
  • Author(s): Ooka E, et al
  • Journal Title: Am J Ophthalmol Volume: 152 Issue: 2 Pages: 283-290
  • DOI: 10.1016/j.ajo.2011.02.001
  • Peer Reviewed
• [Journal Article] Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy (2010)
  • Author(s): Yoshida-Hata N、Mitamura Y、Oshitari T、Namekata K、Harada C、Harada T、Yamamoto S
  • Journal Title: Diabetes Res Clin Pract Volume: 87 Issue: 3 Pages: e26-e28
  • DOI: 10.1016/j.diabres.2009.12.008
  • Peer Reviewed
• [Journal Article] Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy. (2010)
  • Author(s): Yoshida-Hata N, et al
  • Journal Title: Diabetes Res Clin Pract Volume: 87
  • Peer Reviewed
• [Presentation] 増殖糖尿病網膜症の眼内における PML 発現の解析 (2012)
  • Author(s): 香留崇
  • Organizer: 第18回日本糖尿病眼学会総会
  • Place of Presentation: アクロス福岡(福岡市)
  • Year and Date: 2012-11-02
• [Presentation] 増殖糖尿病網膜症の眼内におけるPML発現の解析 (2012)
  • Author(s): 香留崇
  • Organizer: 第18回日本糖尿病眼学会総会
  • Place of Presentation: アクロス福岡（福岡県）