| Project/Area Number |
22591954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
TSUBURA Airo 関西医科大学, 医学部, 教授 (90098137)
YURI Takashi 関西医科大学, 医学部, 講師 (50330212)
UEHARA Norihisa 関西医科大学, 医学部, 講師 (30368211)
KIMURA Ayako 関西医科大学, 医学部, 助教 (80548397)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アポトーシス / オートファジー / カルパイン阻害剤 / 眼病理学 / 視細胞 / 実験動物学 / 毒性 / 網膜色素変性症 / MNU / ENU |
|---|
| Research Abstract |
Autophagy (AP) is intracellular protein degradation pathway that eukaryote universally possesses, and AP contributes to neuronal degenerative diseases and eye diseases such as age-related macular degeneration and glaucoma. In our research, MNU-induced and genetic retinal degeneration mouse models were related to the inhibition of AP in retina. Calpain inhibitor successfully ameliorated photoreceptor cell death in MNU-induced mouse model, which restored basal level of AP in retina.
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