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Involvement of autophagy in MNU-induced retinal degeneration model and its molecular control

Research Project

Project/Area Number 22591954
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKansai Medical University

Principal Investigator

YOSHIZAWA Katsuhiko  関西医科大学, 医学部, 講師 (70548396)

Co-Investigator(Kenkyū-buntansha) TSUBURA Airo  関西医科大学, 医学部, 教授 (90098137)
YURI Takashi  関西医科大学, 医学部, 講師 (50330212)
UEHARA Norihisa  関西医科大学, 医学部, 講師 (30368211)
KIMURA Ayako  関西医科大学, 医学部, 助教 (80548397)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsアポトーシス / オートファジー / カルパイン阻害剤 / 眼病理学 / 視細胞 / 実験動物学 / 毒性 / 網膜色素変性症 / MNU / ENU
Research Abstract

Autophagy (AP) is intracellular protein degradation pathway that eukaryote universally possesses, and AP contributes to neuronal degenerative diseases and eye diseases such as age-related macular degeneration and glaucoma. In our research, MNU-induced and genetic retinal degeneration mouse models were related to the inhibition of AP in retina. Calpain inhibitor successfully ameliorated photoreceptor cell death in MNU-induced mouse model, which restored basal level of AP in retina.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (12 results) Book (2 results) Remarks (3 results)

  • [Journal Article] <i>N</i>-Ethyl-<i>N</i>-Nitrosourea Induces Retinal Photoreceptor Damage in Adult Rats2012

    • Author(s)
      Yoshizawa K, Sasaki T, Uehara N, Kuro M, Kimura A, Kinoshita Y, Miki H, Yuri T, Tsubura A.
    • Journal Title

      Journal of Toxicologic Pathology

      Volume: 25 Issue: 1 Pages: 27-35

    • DOI

      10.1293/tox.25.27

    • NAID

      130001884594

    • ISSN
      0914-9198, 1881-915X
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Ethyl-N-nitrosourea Retinal induces retinal photoreceptor damage in adult rats2012

    • Author(s)
      Yoshizawa K, Sasaki T, Uehara N, Kuro M, Kimura A, Kinoshita Y, Miki H, Yuri T, Tsubura A
    • Journal Title

      J Toxicol Pathol

      Volume: 25 Pages: 27-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corneal damage induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea.2011

    • Author(s)
      Yoshizawa K, Sasaki T, Kuro M, Miki H, Kimura A, Uehara N, Yuri T, Tsubura A.
    • Journal Title

      In Vivo

      Volume: 25 Pages: 609-616

    • URL

      http://iv.iiarjournals.org/content/25/4/609.abstract

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea.2011

    • Author(s)
      Yoshizawa K, Kuro-Kuwata M, Sasaki T, Lai C, Kanematsu S, Miki H, Kimura-Kawanaka A, Uehara N, Yuri T, Tsubura A.
    • Journal Title

      Toxicol Pathol

      Volume: 39 Issue: 4 Pages: 606-613

    • DOI

      10.1177/0192623311402221

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice.2011

    • Author(s)
      Kuro M, Yoshizawa K, Uehara N, Miki H, Takahashi K, Tsubura A.
    • Journal Title

      In Vivo

      Volume: 25 Pages: 617-623

    • URL

      http://iv.iiarjournals.org/content/25/4/617.abstract

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corneal damage induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea2011

    • Author(s)
      Yoshizawa K, Sasaki T, Kuro M, Miki H, Kimura A, Uehara N, Yuri T, Tsubura A
    • Journal Title

      In Vivo

      Volume: 25 Pages: 609-616

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea2011

    • Author(s)
      Yoshizawa K, Kuro-Kuwata M, Sasaki T, Lai C, Kanematsu S, Miki H, Kimura-Kawanaka A, Uehara N, Yuri T, Tsubura A
    • Journal Title

      Toxicol Pathol

      Volume: 39 Pages: 606-613

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese marague (Macaca fuscata).2010

    • Author(s)
      Yoshizawa K, Nakao K, Habiro M, Hayashi K, Kuwata M, Uehara N, Yuri T, Nakamura K, Tsubura A.
    • Journal Title

      Toxicol Pathol

      Volume: 38 Issue: 7 Pages: 1058-1063

    • DOI

      10.1177/0192623310382561

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese marague(Macaca fuscata).2010

    • Author(s)
      Yoshizawa K, Nakao K, Habiro M, Hayashi K, Kuwata M, Uehara N, Yuri T, Nakamura K, Tsubura A.
    • Journal Title

      Toxicol Pathol

      Volume: 38 Pages: 1058-1063

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Calpain inhibition restores basal autophagy and suppresses apoptosis on MNU-induced photoreceptor cell injury in mice.2011

    • Author(s)
      Kuro M, Yoshizawa K, Uehara N, Miki H, Takahashi K, Tsubura A.
    • Organizer
      Association for Reseach in Vision and Ophthalmology.
    • Place of Presentation
      米国フロリダ
    • Year and Date
      2011-05-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Calpain inhibition restores basal autophagy and suppresses apoptosis on MNU-induced photoreceptor cell injury in mice2011

    • Author(s)
      Kuro M, Yoshizawa K, Uehara N, Miki H, Takahashi K, Tsubura A
    • Organizer
      Association for Reseach in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida、USA
    • Year and Date
      2011-05-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] エチルニトロソ尿素によるマウス網膜変性症の病理学的特徴.2011

    • Author(s)
      義澤克彦,畔満喜,佐々木朋,三城弥範,木村彩子,上原範久,圦貴司,螺良愛郎.
    • Organizer
      第100回日本病理学会横浜
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] MNU誘発マウス網膜変性におけるカルパイン阻害剤によるオートファジーの保持と視細胞死の抑制.2011

    • Author(s)
      畔満喜,義澤克彦,上原範久,頼彦長,兼松清果,三城弥範,木村彩子,圦貴司,高橋寛二,螺良愛郎.
    • Organizer
      第100回日本病理学会横浜
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮質盲ならびに癲癇症状を示した実験用ニホンザルの一剖検例.2011

    • Author(s)
      義澤克彦,桑田満喜,頼彦長,兼松清果,三城弥範,川中彩子,上原範久,圦貴司,螺良愛郎.
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea. D2011

    • Author(s)
      Yoshizawa K, Sasaki T, Kuro M, Miki H, Kimura A, Uehara N, Yuri T, Tsubura A.
    • Organizer
      第30回米国毒性病理学会総会
    • Place of Presentation
      米国デンバー
    • Related Report
      2012 Final Research Report
  • [Presentation] 動物モデルを用いたヒト眼科疾患の予防・治療法開発への応用2010

    • Author(s)
      義澤克彦, 螺良愛郎
    • Organizer
      第16回日本食品化学学会学術集会
    • Place of Presentation
      大阪・大阪国際交流センター
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動物モデルを用いたヒト眼科疾患の予防・治療法開発への応用.2010

    • Author(s)
      義澤克彦,螺良愛郎.
    • Organizer
      第16回日本食品化学学会大阪
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2010-06-08
    • Related Report
      2012 Final Research Report
  • [Presentation] MNUマウス誘発網膜変性におけるオートファジーの関与とその制御.2010

    • Author(s)
      桑田満喜,上原範久,義澤克彦,頼彦長,兼松清果,三城弥範,川中彩子,圦貴司,螺良愛郎.
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2010-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮質盲ならびに癩痛症状を示した実験用ニホンザルの-剖検例2010

    • Author(s)
      義澤克彦, 桑田満喜, 頼彦長, 兼松清果, 三城弥範, 川中彩子, 上原範久, 圦貴司, 螺良愛郎
    • Organizer
      第99回日本病理学会学術集会
    • Place of Presentation
      東京・京王プラザホテル
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] MNUマウス誘発網膜変性におけるオートファジーの関与とその制御2010

    • Author(s)
      桑田満喜, 上原範久, 義澤克彦, 頼彦長, 兼松清果, 三城弥範, 川中彩子, 杁貴司, 螺良愛郎
    • Organizer
      第99回日本病理学会学術集会
    • Place of Presentation
      東京・京王プラザホテル
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Arachidonic acid supplementation during gestational, lactational and post-weaning periods prevents retinal degeration induced by N-methyl-N-nitrosourea in young Lewis rats.

    • Author(s)
      Yoshizawa K, Sasaki T, Kuro M, Uehara N, Takada H, Harauma A, Ohara N, Moriguchi T, Tsubura A.
    • Organizer
      第39回日本毒性学会/The 6th Int Cong Asian Soc Toxicol
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Annual Research Report
  • [Book] 学際企画2011

    • Author(s)
      畔満喜,義澤克彦,螺良愛郎
    • Total Pages
      370
    • Publisher
      薬剤誘発網膜変性.モノグラフ病気の分子形態学.日本臨床分子形態学会(編集)
    • Related Report
      2012 Final Research Report
  • [Book] モノグラフ病気の分子形態学2011

    • Author(s)
      畔満喜, 義澤克彦, 螺良愛郎
    • Publisher
      学際企画(株)
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www3.kmu.ac.jp/pathol2/

    • Related Report
      2012 Final Research Report
  • [Remarks] 関西医科大学 教員情報

    • URL

      http://research.kmu.ac.jp/kmuhp/KgApp?kyoinId=yssbyo

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www3.kmu.ac.jp/path2/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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