Suppression of murine experimental autoimmune optic neuritis byinnovation of mature dendritic cells transfected with calcitoningene-related peptide gene
| Project/Area Number |
22591967
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
USUI Yoshihiko 東京医科大学, 医学部, 講師 (50408142)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 視神経炎 / 免疫制御療法 / 細胞治療 / 抗アクアポリン4抗体 / 抗 MOG 抗体 / IL-10 / 多発性硬化症 / 視神経脊髄炎 / 抗アクアポリン４抗体 / 抗MOG抗体 / CGRP / 実験的自己免疫性視神経炎 / 免疫制御 / 自己免疫性視神経炎 / Myelin/oligodendrocyte glycoprotein / マイクログリア / アクアポリン4抗体 / アストロサイト |
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| Research Abstract |
The disease becomes severe in individuals who possess anti-AQP4 antibodies, together with anti-myelin oligodendrocyte glycoprotein (MOG) antibodies. In optic neuritis models, visual acuity decreases first, infiltration of microglia andinflammatory cells. Thereafter, the number of axons decreases and latency of visually evoked potential (VEP) is prolonged. Applying this phenomenon, cell therapy using dendritic cells transfected with CGRP or dendritic cells transfected with IL-10 was attempted, and was found to be effective in suppressing optic neuritis. At the same time, as a more practical therapy, administration of the new multiple sclerosis drug fingolimodsuggests suppression of cell infiltration into the optic nerve.
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Report
(4 results)
Research Products
(28 results)
