Effects of hyperlipidemia and hyperglycemia to wound healing of skin

• Project/Area Number: 22591997
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: The University of Tokushima
• Principal Investigator: NAKANISHI Hideki 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90164235)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Ichiro 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (70314870)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 創傷治癒 / 糖尿病 / 高脂血症

Research Abstract

Effects of leech therapy were studied about the microcirculation of skin flap. Basic data of effect of the leech therapy were collected on the basis of transcutaneous PO2 and PCO2 on skin flaps. Although the effect of the leech therapy on the hyperlipidemia and hyperglycemia was studied, differences between normal condition and these conditions were not clear.

Research Products

• [Journal Article] Limb salvage and vascular augmentation by microsurgical free flap transfer on neuropathic diabetic foot ulcer (2014)
  • Author(s): Ichiro Hashimoto, Yoshiro Abe, Atsushi Morimoto, Keisuke Kashiwagi, Keiichi Goishi, Hideki Nakanishi
  • Journal Title: The Journal of Medical Investigation Volume: (in press)
  • Peer Reviewed
• [Journal Article] Effects of neutrophil elastase inhibitor on flap survival after venous ischemia (2013)
  • Author(s): Kunio Kotsu, Ichiro Hashimoto, Masahiro Yamano, Keisuke Kashiwagi, Yoshiro Abe, Hideki Nakanishi
  • Journal Title: European Journal of Plastic Surgery Volume: 36 Pages: 149-154
  • Peer Reviewed
• [Journal Article] Quantitative analysis of hemodynamics of congested island flaps under leech therapy (2013)
  • Author(s): Keisuke Kashiwagi, Ichiro Hashimoto, Yoshiro Abe, Kunio Kotsu, Masahiro Yamano, Hideki Nakanishi
  • Journal Title: Journal of Medical Investigation Volume: 60 Pages: 213-220
  • NAID: 130004822685
  • Peer Reviewed
• [Journal Article] Transcutaneous PCO2 Measurement at Low Temperature for Reliable and Continuous Free Flap Monitoring : Experimental and Clinical Study (2013)
  • Author(s): Yoshiro Abe, Ichiro Hashimoto, Keiichi Goishi, Keisuke Kashiwagi, Masahiro Yamano, Hideki Nakanishi
  • Journal Title: Plastic and Reconstructive Surgery Global Open Volume: 1 Issue: 2 Pages: 1-8
  • DOI: 10.1097/gox.0b013e3182936cd0
  • Peer Reviewed
• [Journal Article] Quantitative analysis of hemodynamics of congested island flaps under leech therapy (2013)
  • Author(s): Keisuke Kashiwagi, Ichiro Hashimoto, Yoshiro Abe, Kunio Kotsu, Masahiro Yamano, Hideki Nakanishi
  • Journal Title: The Journal of Medical Investigation Volume: 60 Pages: 213-220
  • NAID: 130004822685
  • Peer Reviewed
• [Journal Article] Early postoperative evaluation of secondary bone grafting into the alveolar cleft and its effects on subsequent orthodontic treatment (2012)
  • Author(s): Takuya Seike, Ichiro Hashimoto, Kazuya Matsumoto, Eiji Tanaka, Hideki Nakanishi
  • Journal Title: The Journal of Medical Investigation Volume: 59 Pages: 152-165
  • NAID: 130004465260
  • Peer Reviewed
• [Journal Article] Usefulness in Combined Free Antero- lateral Thigh and Vastus Lateralis Muscle Flaps (2012)
  • Author(s): Ichiro Hashimoto, Hideki Nakanishi, Masahiro Yamano, and Yoshiro Abe
  • Journal Title: European Journal of Plastic Surgery Volume: 35 Pages: 867-872
  • Peer Reviewed
• [Journal Article] Usefulness in Combined Free Anterolateral Thigh and Vastus Lateralis Muscle Flaps (2012)
  • Author(s): Ichiro Hashimoto
  • Journal Title: European Journal of Plastic Surgery Volume: 35 Issue: 12 Pages: 867-872
  • DOI: 10.1007/s00238-012-0743-x
  • Peer Reviewed
• [Journal Article] Resin splint as a new conservative treatment for ingrown toenails (2010)
  • Author(s): Kazuya Matsumoto, Ichiro Hashimoto, Hideki Nakanishi, Yoshiaki Kubo, Kazutoshi Murao, Seiji Arase
  • Journal Title: The Journal of Medical Investigation Volume: 57 Pages: 321-325
  • NAID: 130004465224
  • Peer Reviewed
• [Presentation] Toe amputation with vascularised tissue coverage for preservation of longer metatarsal bone on DM neuro- pathic foot (2012)
  • Author(s): Ichiro Hashimoto, Hideki Nakanishi
  • Organizer: The 11th Japan-Korea Congress of Plastic and Reconstructive Surgery
  • Place of Presentation: 淡路夢舞台国際会議場, (兵庫県)
  • Year and Date: 2012-05-17
• [Presentation] Toe amputation with vascularised tissue coverage for preservation of longer metatarsal bone on DM neuropathic foot (2012)
  • Author(s): Ichiro Hashimoto
  • Organizer: The 11th Japan-Korea Congress of Plastic and Reconstructive Surgery
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県）
• [Presentation] Pudendal Artery Perforator Flap (Gluteal Fold Flap) for Perineal Reconstruction; Reliability and Versatility of the Flap (2011)
  • Author(s): Ichiro Hashimoto, Hideki Nakanishi
  • Organizer: The 16th World Congress of the International Confederation for Plastic, Recons- tructive and Aesthetic Surgery
  • Place of Presentation: Vancouver Convention Center, (Canada)
  • Year and Date: 2011-05-23
• [Presentation] Pudendal Artery Perforator Flap (Gluteal Fod Flap) for Perineal Reconstruction ; Reliability and Versatility of the Flap (2011)
  • Author(s): Ichiro Hashimoto
  • Organizer: The 16th World Congress of the International Confederation for Plastic, Reconstructive and Aesthetic Surgery
  • Place of Presentation: Vancouver, Canada
• [Presentation] 経皮二酸化炭素分圧による皮弁循環不全のモニター方法 (2010)
  • Author(s): 橋本一郎、中西秀樹
  • Organizer: 第19回日本形成外科学会基礎学術集会シンポジウム
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-09-17
• [Presentation] 経皮二酸化炭素分圧による皮弁循環不全のモニター方法 (2010)
  • Author(s): 橋本一郎、中西秀樹
  • Organizer: 第19回日本形成外科学会基礎学術集会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-17