Study on Pathogenesis of Neuropathic Pain Following trigeminal Nerve Injury
| Project/Area Number |
22592035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
SUGIMOTO Tomosada 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50135729)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUKA Yoshizo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90243477)
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| Co-Investigator(Renkei-kenkyūsha) |
TERAYAMA Ryuji 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60333689)
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| Research Collaborator |
FUJISAWA Naoko 岡山大学, 大学院・・医歯薬学総合研究科, 大学院・・生
YAMAGUCHI Daisuke 岡山大学, 大学院・医歯薬学総合研究科, 大学院生
OMURA Shinji 岡山大学, 大学院・医歯薬学総合研究科, 大学院生
TSUCHIYA Yasunori 岡山大学, 大学院・医歯薬学総合研究科, 大学院・生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経切断 / 三叉神経 / 神経障害性疼痛 / 吻側亜核 / 尾側亜核 / 脊髄後角 / アデノシンA1受容体 / c-Fos / 脊髄路核 / 舌神経 / 神経因性疼痛 |
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| Research Abstract |
The trigeminal nerve conveys nociceptive signals to the subnuceli oralis and caudalis. Following peripheral nerve injury, weak innocuous peripheral stimulation induces oralis neuronal responses similar to those evoked by noxious stimulation. On the other hand the number of neurons in the subnucleus caudalis and the spinal dorsal horn responding to noxious peripheral stimulation increases following trigeminal and spinal nerves. Activation of peripheral adenosine A1 receptors suppresses the injury-induced hyper-responsiveness of dorsal horn neurons and attenuates neuropathic hyperalgesia.
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Report
(4 results)
Research Products
(22 results)
