| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Sjogren’s syndrome is a chronic inflammatory autoimmune disorder that affects mainly salivary and lacrimal gland, resulting in dry mouth and dry eyes symptoms. In this study, to understand the regulatory mechanism of inflammation in salivary gland, oxidative stress response was investigated using human submaxillary salivary gland A-253 cells. A whole human genome micro-array analysis showed that the expression levels of pro-inflammatory cytokines such as IL-6, IL-18 and CXCL1 were increased in H2O2 treated cells compared with control cells. While, anti-inflammatory cytokine IL-11 was up-regulated in H2O2 treated cells. These results suggest that the target tissue itself might have a role on regulation of peripheral inflammation. IL-11 might be a candidate molecule for substitution therapy. Furthermore, a soluble isoform of IL-17 receptor A (IL-17RA) was identified in human salivary gland. IL-17 was supposed to a key molecule of inflammatory disorders such as Sjogren’s syndrome, rheumatoid arthritis and Crohn’s disease. The soluble isoform of IL-17 RA could be an endogenous antagonist against the IL-17 signaling.
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